Your Input: | |
| | W5NU85_SHEEP | Uncharacterized protein. (711 aa) |
| | RAD51B | RAD51 paralog B. (290 aa) |
| | ZFYVE26 | Zinc finger FYVE-type containing 26. (2521 aa) |
| | C14orf39 | Chromosome 14 open reading frame 39. (584 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | BCL6 | BCL6 transcription repressor. (702 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (649 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | TM4SF19 | Uncharacterized protein. (208 aa) |
| | INO80 | INO80 complex ATPase subunit. (1565 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | SYCP1 | Synaptonemal complex protein 1. (1000 aa) |
| | SYCE3 | Synaptonemal complex central element protein 3. (87 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (198 aa) |
| | CCNB1IP1 | Cyclin B1 interacting protein 1. (277 aa) |
| | HDAC10 | Histone deacetylase 10. (671 aa) |
| | TEP1 | Telomerase associated protein 1. (2621 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | SFPQ | Splicing factor proline and glutamine rich. (654 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (733 aa) |
| | RNF212B | Ring finger protein 212B. (300 aa) |
| | REC8 | REC8 meiotic recombination protein. (592 aa) |
| | REC114 | REC114 meiotic recombination protein. (214 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (263 aa) |
| | RAD21L1 | RAD21 cohesin complex component like 1. (554 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (830 aa) |
| | XRCC6 | SAP domain-containing protein. (612 aa) |
| | SWSAP1 | SWIM-type zinc finger 7 associated protein 1. (250 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (552 aa) |
| | MCM8 | MCM domain-containing protein; Belongs to the MCM family. (835 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (395 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (681 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (713 aa) |
| | CDC45 | Cell division cycle 45. (549 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (543 aa) |
| | ZSWIM7 | Zinc finger SWIM-type containing 7. (145 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (611 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1194 aa) |
| | W5Q6T9_SHEEP | MLVIN_C domain-containing protein. (89 aa) |
| | HMGB1 | Uncharacterized protein. (203 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (284 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (617 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (919 aa) |
| | ANKRD31 | ANK_REP_REGION domain-containing protein. (1276 aa) |
| | MEIOB | Uncharacterized protein. (202 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1101 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa) |
| | RAD51AP2 | RAD51 associated protein 2. (1153 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (352 aa) |
| | C1orf146 | Chromosome 1 open reading frame 146. (181 aa) |
| | W5Q3M0_SHEEP | Uncharacterized protein. (717 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (995 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1022 aa) |
| | TRIP13 | Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (409 aa) |
| | CDC7 | Cell division cycle 7. (582 aa) |
| | TEX11 | Testis expressed 11. (920 aa) |
| | HFM1 | Helicase for meiosis 1. (1434 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (627 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (332 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa) |
| | POLN | DNA polymerase nu. (901 aa) |
| | W5Q0U1_SHEEP | Uncharacterized protein. (837 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1444 aa) |
| | W5Q077_SHEEP | MLVIN_C domain-containing protein. (136 aa) |
| | W5Q054_SHEEP | Uncharacterized protein. (127 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1125 aa) |
| | W5PZP6_SHEEP | Uncharacterized protein. (925 aa) |
| | MORF4L1 | Mortality factor 4 like 1. (360 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (451 aa) |
| | W5PYR2_SHEEP | MRG domain-containing protein. (360 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | W5PYH0_SHEEP | MLVIN_C domain-containing protein. (91 aa) |
| | W5PYE4_SHEEP | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (305 aa) |
| | W5PY93_SHEEP | MLVIN_C domain-containing protein. (105 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1546 aa) |
| | CCDC36 | Coiled-coil domain containing 36. (599 aa) |
| | NABP1 | Nucleic acid binding protein 1. (208 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (887 aa) |
| | W5PXI1_SHEEP | MLVIN_C domain-containing protein. (221 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | TCF7 | Transcription factor 7. (378 aa) |
| | EPC1 | Enhancer of polycomb homolog. (813 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1363 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (564 aa) |
| | RECQL4 | RecQ like helicase 4. (1105 aa) |
| | SMC5 | SMC_N domain-containing protein. (1167 aa) |
| | BLM | BLM RecQ like helicase. (1429 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (773 aa) |
| | MSH4 | MutS homolog 4. (935 aa) |
| | FBH1 | F-box DNA helicase 1. (1046 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | TCF3 | Transcription factor 3. (617 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (416 aa) |
| | W5NPE7_SHEEP | Reverse transcriptase domain-containing protein. (1272 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1021 aa) |
| | W5NPN2_SHEEP | RNase H domain-containing protein. (622 aa) |
| | WRN | WRN RecQ like helicase. (1406 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (649 aa) |
| | W5NQ32_SHEEP | MLVIN_C domain-containing protein. (89 aa) |
| | W5NQJ4_SHEEP | Uncharacterized protein. (422 aa) |
| | W5NQW3_SHEEP | MLVIN_C domain-containing protein. (104 aa) |
| | AP5S1 | Adaptor related protein complex 5 subunit sigma 1. (203 aa) |
| | INTS3 | Integrator complex subunit 3. (1040 aa) |
| | W5NSS7_SHEEP | Reverse transcriptase domain-containing protein. (1272 aa) |
| | KIAA1841 | KIAA1841. (723 aa) |
| | YY1 | YY1 transcription factor. (348 aa) |
| | W5NUN9_SHEEP | MRG domain-containing protein. (158 aa) |
| | BATF | Basic leucine zipper ATF-like transcription factor. (124 aa) |
| | W5NUQ9_SHEEP | BRCT domain-containing protein. (212 aa) |
| | W5NUX2_SHEEP | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (308 aa) |
| | WDR48 | WD repeat domain 48. (677 aa) |
| | AICDA | Activation induced cytidine deaminase. (201 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1732 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | RAD54L | RAD54 like. (750 aa) |
| | PSMC3IP | PSMC3 interacting protein. (217 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | HELQ | Helicase, POLQ like. (1064 aa) |
| | W5NXB6_SHEEP | MLVIN_C domain-containing protein. (123 aa) |
| | MCM2 | MCM domain-containing protein; Belongs to the MCM family. (237 aa) |
| | MBTD1 | Mbt domain containing 1. (632 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (288 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1893 aa) |
| | SWAP70 | Switching B cell complex subunit SWAP70. (600 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1245 aa) |
| | TPRKB | TP53RK binding protein; Belongs to the CGI121/TPRKB family. (175 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4120 aa) |
| | W5PQP5_SHEEP | Uncharacterized protein. (214 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa) |
| | FANCB | FA complementation group B. (858 aa) |
| | W5PPW4_SHEEP | Uncharacterized protein. (191 aa) |
| | W5PPS0_SHEEP | Uncharacterized protein. (201 aa) |
| | RAD51C | RAD51 paralog C. (384 aa) |
| | LIG1 | DNA ligase. (920 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (155 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | HSF2BP | Heat shock transcription factor 2 binding protein. (334 aa) |
| | SPIDR | Scaffold protein involved in DNA repair. (950 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3427 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa) |
| | EXOSC6 | Uncharacterized protein. (130 aa) |
| | W5PMJ6_SHEEP | Reverse transcriptase domain-containing protein. (1272 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (757 aa) |
| | SWI5 | Uncharacterized protein. (171 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | NIPBL | Nipped-B protein. (2804 aa) |
| | W5PLD9_SHEEP | MLVIN_C domain-containing protein. (136 aa) |
| | RAG2 | Recombination activating 2. (527 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1276 aa) |
| | RAD21 | RAD21 cohesin complex component. (630 aa) |
| | FOXP3 | Fork-head domain-containing protein. (474 aa) |
| | MND1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (204 aa) |
| | TFPT | TCF3 fusion partner. (253 aa) |
| | PGBD5 | PiggyBac transposable element derived 5. (523 aa) |
| | W5NZ27_SHEEP | MLVIN_C domain-containing protein. (104 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (318 aa) |
| | SLX1 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (275 aa) |
| | RMI1 | RecQ mediated genome instability 1. (623 aa) |
| | RPAIN | RPA interacting protein. (219 aa) |
| | AP5Z1 | Adaptor related protein complex 5 subunit zeta 1. (826 aa) |
| | UBR2 | E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1764 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | RECQL5 | RecQ like helicase 5. (1014 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (299 aa) |
| | W5PJE1_SHEEP | Uncharacterized protein. (935 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (328 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3056 aa) |
| | NABP2 | Nucleic acid binding protein 2. (154 aa) |
| | W5PI72_SHEEP | SAP domain-containing protein. (565 aa) |
| | FANCM | FA complementation group M. (2043 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (632 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa) |
| | C21H11orf80 | Uncharacterized protein. (421 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (277 aa) |
| | RBBP8 | Uncharacterized protein. (887 aa) |
| | W5PED2_SHEEP | Uncharacterized protein. (797 aa) |
| | LIG3 | DNA ligase. (1010 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (399 aa) |
| | C5H19orf57 | Uncharacterized protein. (659 aa) |
| | W5PDD7_SHEEP | MLVIN_C domain-containing protein. (136 aa) |
| | RAD54B | Uncharacterized protein. (811 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (693 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1507 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | HROB | Chromosome 17 open reading frame 53. (685 aa) |
| | EXO1 | Exonuclease 1. (835 aa) |
| | W5PAN5_SHEEP | MCM domain-containing protein; Belongs to the MCM family. (871 aa) |
| | MEI4 | Meiotic double-stranded break formation protein 4. (395 aa) |
| | PSMD14 | Proteasome 26S subunit, non-ATPase 14. (309 aa) |
| | W5P9K9_SHEEP | Uncharacterized protein. (119 aa) |
| | SHOC1 | Shortage in chiasmata 1. (1511 aa) |
| | RMI2 | RecQ mediated genome instability 2. (159 aa) |
| | INIP | INTS3 and NABP interacting protein. (104 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (352 aa) |
| | W5P892_SHEEP | MLVIN_C domain-containing protein. (98 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (299 aa) |
| | RNF138 | Ring finger protein 138. (199 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (790 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (281 aa) |
| | W5P729_SHEEP | Reverse transcriptase domain-containing protein. (1175 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (373 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | LIG4 | DNA ligase. (757 aa) |
| | PAGR1 | PAXIP1 associated glutamate rich protein 1. (254 aa) |
| | W5P5U1_SHEEP | Uncharacterized protein. (472 aa) |
| | SUPV3L1 | Suv3 like RNA helicase. (655 aa) |
| | W5P5Q1_SHEEP | Uncharacterized protein. (209 aa) |
| | W5P5E4_SHEEP | DNA_MISMATCH_REPAIR_2 domain-containing protein. (835 aa) |
| | W5P5D0_SHEEP | Uncharacterized protein. (372 aa) |
| | FANCD2 | FA complementation group D2. (1454 aa) |
| | CENPS | Centromere protein S. (139 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1352 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (419 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1857 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (590 aa) |
| | INO80E | INO80 complex subunit E. (249 aa) |
| | W5P2F8_SHEEP | Uncharacterized protein. (68 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1613 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
