98 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MEI4	Meiotic double-stranded break formation protein 4. (395 aa)
	TDRD9	Tudor domain containing 9. (1344 aa)
	SHOC1	Shortage in chiasmata 1. (1511 aa)
	NDC1	NDC1 transmembrane nucleoporin. (676 aa)
	CCNE2	Cyclin E2; Belongs to the cyclin family. (404 aa)
	SUN1	Sad1 and UNC84 domain containing 1. (814 aa)
	BIRC5	Baculoviral IAP repeat containing 5. (142 aa)
	ING2	Inhibitor of growth protein. (283 aa)
	BAG6	BCL2 associated athanogene 6. (1152 aa)
	ERCC4	ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
	W5PBQ6_SHEEP	Uncharacterized protein. (171 aa)
	RAD51D	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa)
	DDX4	DEAD-box helicase 4; Belongs to the DEAD box helicase family. (732 aa)
	RAD54B	Uncharacterized protein. (811 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	C5H19orf57	Uncharacterized protein. (659 aa)
	TERF1	Telomeric repeat binding factor 1. (342 aa)
	W5P5E4_SHEEP	DNA_MISMATCH_REPAIR_2 domain-containing protein. (835 aa)
	FANCD2	FA complementation group D2. (1454 aa)
	CENPS	Centromere protein S. (139 aa)
	EME1	Essential meiotic structure-specific endonuclease 1. (590 aa)
	TOP2B	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1613 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (411 aa)
	FBXO5	F-box protein 5. (413 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1764 aa)
	RMI1	RecQ mediated genome instability 1. (623 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1268 aa)
	MND1	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (204 aa)
	FOXJ2	Forkhead box J2. (576 aa)
	PSMC3IP	PSMC3 interacting protein. (217 aa)
	RAD54L	RAD54 like. (750 aa)
	TERB1	Telomere repeat binding bouquet formation protein 1. (732 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
	SLX4	SLX4 structure-specific endonuclease subunit. (1732 aa)
	MLH3	MutL homolog 3. (1485 aa)
	CDC25B	Cell division cycle 25B. (574 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
	RPL10L	Ribosomal protein L10 like. (214 aa)
	TEX15	Testis expressed 15, meiosis and synapsis associated. (3179 aa)
	C21H11orf80	Uncharacterized protein. (421 aa)
	DMRTC2	DMRT like family C2. (414 aa)
	PSMD13	Proteasome 26S subunit, non-ATPase 13. (376 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (963 aa)
	FANCM	FA complementation group M. (2043 aa)
	SYCE2	Synaptonemal complex central element protein 2. (184 aa)
	BRCA2	BRCA2 DNA repair associated. (3427 aa)
	HSF2BP	Heat shock transcription factor 2 binding protein. (334 aa)
	MAJIN	Membrane anchored junction protein. (257 aa)
	RAD51C	RAD51 paralog C. (384 aa)
	DNMT3L	PHD-type domain-containing protein. (420 aa)
	MAEL	Maelstrom spermatogenic transposon silencer. (437 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
	MSH4	MutS homolog 4. (935 aa)
	M1AP	Meiosis 1 associated protein. (533 aa)
	CCDC155	Coiled-coil domain containing 155. (564 aa)
	DMRT1	Doublesex and mab-3 related transcription factor 1. (332 aa)
	SYCE1	Synaptonemal complex central element protein 1. (323 aa)
	PTTG1	Uncharacterized protein. (202 aa)
	UBE2B	Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
	CCDC36	Coiled-coil domain containing 36. (599 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1546 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
	W5PYF0_SHEEP	Shugoshin_C domain-containing protein. (378 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
	HFM1	Helicase for meiosis 1. (1434 aa)
	SGO1	Shugoshin_C domain-containing protein. (521 aa)
	TEX11	Testis expressed 11. (920 aa)
	SGO2	Shugoshin 2. (1245 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (409 aa)
	BRIP1	BRCA1 interacting protein C-terminal helicase 1. (995 aa)
	SLC25A31	Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (324 aa)
	C1orf146	Chromosome 1 open reading frame 146. (181 aa)
	TEX12	Testis expressed 12. (123 aa)
	EME2	Essential meiotic structure-specific endonuclease subunit 2. (352 aa)
	ESPL1	Extra spindle pole bodies like 1, separase. (2111 aa)
	MEIOB	Uncharacterized protein. (202 aa)
	ANKRD31	ANK_REP_REGION domain-containing protein. (1276 aa)
	SPATA22	Spermatogenesis associated 22. (326 aa)
	ZCWPW1	Zinc finger CW-type and PWWP domain containing 1. (646 aa)
	STAG3	Stromal antigen 3. (1275 aa)
	ANKLE1	Ankyrin repeat and LEM domain containing 1. (611 aa)
	PLK1	Serine/threonine-protein kinase PLK. (605 aa)
	SIRT7	Sirtuin 7. (323 aa)
	ZSCAN21	Zinc finger and SCAN domain containing 21. (471 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (395 aa)
	MUS81	MUS81 structure-specific endonuclease subunit. (552 aa)
	AURKA	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (405 aa)
	MEI1	Meiotic double-stranded break formation protein 1. (1261 aa)
	RAD21L1	RAD21 cohesin complex component like 1. (554 aa)
	REC8	REC8 meiotic recombination protein. (592 aa)
	RNF212B	Ring finger protein 212B. (300 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (871 aa)
	CCNB1IP1	Cyclin B1 interacting protein 1. (277 aa)
	SYCE3	Synaptonemal complex central element protein 3. (87 aa)
	SYCP1	Synaptonemal complex protein 1. (1000 aa)
	FOXJ3	Forkhead box J3. (625 aa)
	HORMAD1	HORMA domain containing 1. (393 aa)
	C14orf39	Chromosome 14 open reading frame 39. (584 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD31	HORMAD1	ENSOARP00000017933	ENSOARP00000022408	ANK_REP_REGION domain-containing protein.	HORMA domain containing 1.	0.515
ANKRD31	MAJIN	ENSOARP00000017933	ENSOARP00000012121	ANK_REP_REGION domain-containing protein.	Membrane anchored junction protein.	0.530
ANKRD31	MEI1	ENSOARP00000017933	ENSOARP00000019932	ANK_REP_REGION domain-containing protein.	Meiotic double-stranded break formation protein 1.	0.831
ANKRD31	MEI4	ENSOARP00000017933	ENSOARP00000007256	ANK_REP_REGION domain-containing protein.	Meiotic double-stranded break formation protein 4.	0.536
ANKRD31	MEIOB	ENSOARP00000017933	ENSOARP00000017923	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.430
ANKRD31	MND1	ENSOARP00000017933	ENSOARP00000003191	ANK_REP_REGION domain-containing protein.	Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family.	0.477
ANKRD31	MSH4	ENSOARP00000017933	ENSOARP00000013633	ANK_REP_REGION domain-containing protein.	MutS homolog 4.	0.483
ANKRD31	REC8	ENSOARP00000017933	ENSOARP00000020623	ANK_REP_REGION domain-containing protein.	REC8 meiotic recombination protein.	0.428
ANKRD31	SPO11	ENSOARP00000017933	ENSOARP00000019324	ANK_REP_REGION domain-containing protein.	SPO11 initiator of meiotic double stranded breaks.	0.527
ANKRD31	STAG3	ENSOARP00000017933	ENSOARP00000018490	ANK_REP_REGION domain-containing protein.	Stromal antigen 3.	0.419
ANKRD31	SYCE1	ENSOARP00000017933	ENSOARP00000014418	ANK_REP_REGION domain-containing protein.	Synaptonemal complex central element protein 1.	0.628
ANKRD31	SYCE2	ENSOARP00000017933	ENSOARP00000010843	ANK_REP_REGION domain-containing protein.	Synaptonemal complex central element protein 2.	0.442
ANKRD31	SYCP1	ENSOARP00000017933	ENSOARP00000021568	ANK_REP_REGION domain-containing protein.	Synaptonemal complex protein 1.	0.664
ANKRD31	W5P5E4_SHEEP	ENSOARP00000017933	ENSOARP00000005647	ANK_REP_REGION domain-containing protein.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.416
ATM	BRCA2	ENSOARP00000012764	ENSOARP00000011988	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.958
ATM	BRIP1	ENSOARP00000012764	ENSOARP00000017303	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1 interacting protein C-terminal helicase 1.	0.883
ATM	DMC1	ENSOARP00000012764	ENSOARP00000016725	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.790
ATM	EME1	ENSOARP00000012764	ENSOARP00000004907	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Essential meiotic structure-specific endonuclease 1.	0.612
ATM	ERCC4	ENSOARP00000012764	ENSOARP00000007853	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ERCC excision repair 4, endonuclease catalytic subunit.	0.762
ATM	FANCD2	ENSOARP00000012764	ENSOARP00000005599	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FA complementation group D2.	0.861