21 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MEIOB	Uncharacterized protein. (202 aa)
	HSF2BP	Heat shock transcription factor 2 binding protein. (334 aa)
	BRCA2	BRCA2 DNA repair associated. (3427 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (395 aa)
	ZSCAN21	Zinc finger and SCAN domain containing 21. (471 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (963 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (409 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
	DNMT3L	PHD-type domain-containing protein. (420 aa)
	RPL10L	Ribosomal protein L10 like. (214 aa)
	RAD51C	RAD51 paralog C. (384 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
	FOXJ3	Forkhead box J3. (625 aa)
	REC8	REC8 meiotic recombination protein. (592 aa)
	FOXJ2	Forkhead box J2. (576 aa)
	UBR2	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1764 aa)
	TDRD9	Tudor domain containing 9. (1344 aa)
	ING2	Inhibitor of growth protein. (283 aa)
	SLC25A31	Solute carrier family 25 member 31; Belongs to the mitochondrial carrier (TC 2.A.29) family. (324 aa)
	DDX4	DEAD-box helicase 4; Belongs to the DEAD box helicase family. (732 aa)
	DMRTC2	DMRT like family C2. (414 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA2	DMC1	ENSOARP00000011988	ENSOARP00000016725	BRCA2 DNA repair associated.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.869
BRCA2	HSF2BP	ENSOARP00000011988	ENSOARP00000012082	BRCA2 DNA repair associated.	Heat shock transcription factor 2 binding protein.	0.934
BRCA2	MEIOB	ENSOARP00000011988	ENSOARP00000017923	BRCA2 DNA repair associated.	Uncharacterized protein.	0.804
BRCA2	RAD51C	ENSOARP00000011988	ENSOARP00000012408	BRCA2 DNA repair associated.	RAD51 paralog C.	0.996
BRCA2	SPO11	ENSOARP00000011988	ENSOARP00000019324	BRCA2 DNA repair associated.	SPO11 initiator of meiotic double stranded breaks.	0.621
DDX4	MEIOB	ENSOARP00000008205	ENSOARP00000017923	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.574
DDX4	REC8	ENSOARP00000008205	ENSOARP00000020623	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	REC8 meiotic recombination protein.	0.489
DDX4	SPO11	ENSOARP00000008205	ENSOARP00000019324	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	SPO11 initiator of meiotic double stranded breaks.	0.584
DDX4	TDRD9	ENSOARP00000008205	ENSOARP00000007157	DEAD-box helicase 4; Belongs to the DEAD box helicase family.	Tudor domain containing 9.	0.510
DMC1	BRCA2	ENSOARP00000016725	ENSOARP00000011988	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	BRCA2 DNA repair associated.	0.869
DMC1	MEIOB	ENSOARP00000016725	ENSOARP00000017923	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Uncharacterized protein.	0.792
DMC1	RAD51C	ENSOARP00000016725	ENSOARP00000012408	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	RAD51 paralog C.	0.472
DMC1	REC8	ENSOARP00000016725	ENSOARP00000020623	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	REC8 meiotic recombination protein.	0.921
DMC1	SPO11	ENSOARP00000016725	ENSOARP00000019324	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	SPO11 initiator of meiotic double stranded breaks.	0.883
DMC1	TRIP13	ENSOARP00000016725	ENSOARP00000017264	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.724
DMRTC2	SPO11	ENSOARP00000009001	ENSOARP00000019324	DMRT like family C2.	SPO11 initiator of meiotic double stranded breaks.	0.578
DNMT3L	TDRD9	ENSOARP00000012622	ENSOARP00000007157	PHD-type domain-containing protein.	Tudor domain containing 9.	0.514
HSF2BP	BRCA2	ENSOARP00000012082	ENSOARP00000011988	Heat shock transcription factor 2 binding protein.	BRCA2 DNA repair associated.	0.934
HSF2BP	MEIOB	ENSOARP00000012082	ENSOARP00000017923	Heat shock transcription factor 2 binding protein.	Uncharacterized protein.	0.708
HSF2BP	SPO11	ENSOARP00000012082	ENSOARP00000019324	Heat shock transcription factor 2 binding protein.	SPO11 initiator of meiotic double stranded breaks.	0.480