STRINGSTRING
ZPBP2 ZPBP2 PYGO1 PYGO1 SPATA16 SPATA16 KDM3A KDM3A AGFG1 AGFG1 SPAG17 SPAG17 IQCG IQCG ROPN1 ROPN1 SYCP1 SYCP1 CCNB1IP1 CCNB1IP1 CFAP65 CFAP65 TNP1 TNP1 CFAP44 CFAP44 W5QDB3_SHEEP W5QDB3_SHEEP REC8 REC8 TSSK4 TSSK4 NECTIN3 NECTIN3 TTLL1 TTLL1 TBC1D20 TBC1D20 BBS4 BBS4 W5QC15_SHEEP W5QC15_SHEEP W5QBX3_SHEEP W5QBX3_SHEEP W5QBX1_SHEEP W5QBX1_SHEEP W5QBS8_SHEEP W5QBS8_SHEEP TSSK1B TSSK1B BBS2 BBS2 CFTR CFTR W5Q9F9_SHEEP W5Q9F9_SHEEP SPO11 SPO11 MFSD14A MFSD14A H3F3A H3F3A KLHL10 KLHL10 KAT5 KAT5 CCDC63 CCDC63 TTC12 TTC12 TDRD5 TDRD5 C7orf61 C7orf61 FSIP2 FSIP2 SLC26A6 SLC26A6 TARBP2 TARBP2 PIWIL1 PIWIL1 BRIP1 BRIP1 TRIP13 TRIP13 PAFAH1B1 PAFAH1B1 NME5 NME5 IFT81 IFT81 DMC1 DMC1 SYCP3 SYCP3 ZPBP ZPBP NSUN2 NSUN2 SELENOF SELENOF TBPL1 TBPL1 CATSPER3 CATSPER3 RNF8 RNF8 ROPN1L ROPN1L UBE2B UBE2B STRBP STRBP AFF4 AFF4 SPEM2 SPEM2 SPEM1 SPEM1 CFAP206 CFAP206 W5PTU9_SHEEP W5PTU9_SHEEP SPACA1 SPACA1 W5PTK3_SHEEP W5PTK3_SHEEP UBE2J1 UBE2J1 CFAP221 CFAP221 SLC26A8 SLC26A8 PDILT PDILT SOX30 SOX30 FANCG FANCG CDYL CDYL CEP131 CEP131 KIT KIT W5NPQ0_SHEEP W5NPQ0_SHEEP DRC7 DRC7 PANK2 PANK2 TMEM53 TMEM53 HSPA2 HSPA2 DHH DHH ENSOARP00000001737 ENSOARP00000001737 SPAG6 SPAG6 FSCN3 FSCN3 CCDC42 CCDC42 TTLL5 TTLL5 PLD6 PLD6 DZIP1 DZIP1 VPS13B VPS13B FSCN3-2 FSCN3-2 W5NWP5_SHEEP W5NWP5_SHEEP W5NXJ6_SHEEP W5NXJ6_SHEEP FAM71F2 FAM71F2 FAM71F1 FAM71F1 CCDC136 CCDC136 EHMT2 EHMT2 PSME4 PSME4 SPINK1 SPINK1 EFCAB9 EFCAB9 LOC101115386 LOC101115386 FSHR FSHR NEURL1 NEURL1 RSPH3 RSPH3 GALNTL5 GALNTL5 W5P3Y5_SHEEP W5P3Y5_SHEEP PACRG PACRG LOC101110332 LOC101110332 CCR6 CCR6 PACRGL PACRGL CATSPER4 CATSPER4 W5P5A8_SHEEP W5P5A8_SHEEP DPY19L2 DPY19L2 CATSPERE CATSPERE CFAP97D1 CFAP97D1 DEFB1 DEFB1 PRKACA PRKACA RFX2 RFX2 TNP2 TNP2 CATSPERZ CATSPERZ CFAP43 CFAP43 IQCF1 IQCF1 IQCF5 IQCF5 SLC26A3 SLC26A3 CELF1 CELF1 DLD DLD PITHD1 PITHD1 ING2 ING2 W5PBC1_SHEEP W5PBC1_SHEEP CATSPERD CATSPERD ZMYND15 ZMYND15 CABYR CABYR CFAP58 CFAP58 TSSK6 TSSK6 MEIG1 MEIG1 GK2 GK2 FNDC3A FNDC3A DMRTC2 DMRTC2 HOOK1 HOOK1 BSP5 BSP5 ENSOARP00000009186 ENSOARP00000009186 rsvp14 rsvp14 OSBP2 OSBP2 TPGS1 TPGS1 MEIOC MEIOC CEP57 CEP57 PVR PVR NECTIN2 NECTIN2 LOC101108931 LOC101108931 PLA2G3 PLA2G3 KLC3 KLC3 SEPTIN14 SEPTIN14 AKAP4 AKAP4 TMF1 TMF1 SIX5 SIX5 RSPH6A RSPH6A MKKS MKKS W5PLE7_SHEEP W5PLE7_SHEEP ARMC2 ARMC2 RSPH1 RSPH1 CATSPER2 CATSPER2 TTC26 TTC26 ABHD2 ABHD2 W5PNU4_SHEEP W5PNU4_SHEEP SPEF2 SPEF2 W5PPC7_SHEEP W5PPC7_SHEEP BSPH1 BSPH1 ELSPBP1 ELSPBP1 CFAP157 CFAP157 DDX25 DDX25 PCSK4 PCSK4 CFAP69 CFAP69 CIB1 CIB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZPBP2Zona pellucida binding protein 2. (326 aa)
PYGO1Pygopus family PHD finger 1. (403 aa)
SPATA16Spermatogenesis associated 16. (562 aa)
KDM3ALysine demethylase 3A. (1319 aa)
AGFG1ArfGAP with FG repeats 1. (494 aa)
SPAG17Sperm associated antigen 17. (2150 aa)
IQCGIQ motif containing G. (438 aa)
ROPN1Uncharacterized protein. (212 aa)
SYCP1Synaptonemal complex protein 1. (1000 aa)
CCNB1IP1Cyclin B1 interacting protein 1. (277 aa)
CFAP65Cilia and flagella associated protein 65. (1911 aa)
TNP1Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (55 aa)
CFAP44Cilia and flagella associated protein 44. (1849 aa)
W5QDB3_SHEEPUncharacterized protein. (230 aa)
REC8REC8 meiotic recombination protein. (592 aa)
TSSK4Testis specific serine kinase 4. (338 aa)
NECTIN3Nectin cell adhesion molecule 3. (384 aa)
TTLL1Tubulin tyrosine ligase like 1. (423 aa)
TBC1D20TBC1 domain family member 20. (351 aa)
BBS4Bardet-Biedl syndrome 4. (507 aa)
W5QC15_SHEEPUncharacterized protein. (631 aa)
W5QBX3_SHEEPUncharacterized protein. (213 aa)
W5QBX1_SHEEPUncharacterized protein. (382 aa)
W5QBS8_SHEEPUncharacterized protein. (886 aa)
TSSK1BTestis specific serine kinase 1B; Belongs to the protein kinase superfamily. (354 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1482 aa)
W5Q9F9_SHEEPUncharacterized protein. (585 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
MFSD14AMFS domain-containing protein. (495 aa)
H3F3AHistone H3.3. (136 aa)
KLHL10Kelch like family member 10. (608 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (543 aa)
CCDC63Coiled-coil domain containing 63. (558 aa)
TTC12Tetratricopeptide repeat domain 12. (731 aa)
TDRD5Tudor domain containing 5. (1039 aa)
C7orf61Chromosome 7 open reading frame 61. (204 aa)
FSIP2Fibrous sheath interacting protein 2. (6942 aa)
SLC26A6Solute carrier family 26 member 6. (761 aa)
TARBP2RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (366 aa)
PIWIL1Piwi like RNA-mediated gene silencing 1; Belongs to the argonaute family. (935 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (995 aa)
TRIP13Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (409 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
NME5NME/NM23 family member 5; Belongs to the NDK family. (209 aa)
IFT81Intraflagellar transport 81. (683 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
SYCP3Synaptonemal complex protein 3. (225 aa)
ZPBPZona pellucida binding protein. (276 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (786 aa)
SELENOFSelenoprotein F. (124 aa)
TBPL1TATA-box binding protein like 1. (188 aa)
CATSPER3Cation channel sperm associated 3. (400 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (451 aa)
ROPN1LRhophilin associated tail protein 1 like. (270 aa)
UBE2BUbiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
STRBPUncharacterized protein. (676 aa)
AFF4AF4/FMR2 family member 4. (1163 aa)
SPEM2SPEM family member 2. (511 aa)
SPEM1Spermatid maturation 1. (313 aa)
CFAP206Uncharacterized protein. (625 aa)
W5PTU9_SHEEPUncharacterized protein. (4874 aa)
SPACA1Sperm acrosome associated 1. (292 aa)
W5PTK3_SHEEPUncharacterized protein. (426 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (324 aa)
CFAP221Cilia and flagella associated protein 221. (837 aa)
SLC26A8Testis anion transporter 1. (960 aa)
PDILTProtein disulfide isomerase like, testis expressed. (578 aa)
SOX30SRY-box transcription factor 30. (692 aa)
FANCGFA complementation group G. (569 aa)
CDYLChromodomain Y like. (546 aa)
CEP131Centrosomal protein 131. (1082 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
W5NPQ0_SHEEPUncharacterized protein. (1309 aa)
DRC7Dynein regulatory complex subunit 7. (874 aa)
PANK2Uncharacterized protein. (574 aa)
TMEM53Transmembrane protein 53. (294 aa)
HSPA2Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (636 aa)
DHHUncharacterized protein. (301 aa)
ENSOARP00000001737annotation not available (301 aa)
SPAG6Sperm associated antigen 6. (512 aa)
FSCN3Fascin. (498 aa)
CCDC42Coiled-coil domain containing 42. (316 aa)
TTLL5Tubulin tyrosine ligase like 5. (1333 aa)
PLD6Phospholipase D family member 6. (220 aa)
DZIP1DAZ interacting zinc finger protein 1. (865 aa)
VPS13BVacuolar protein sorting 13 homolog B. (4018 aa)
FSCN3-2Fascin actin-bundling protein 3. (498 aa)
W5NWP5_SHEEPUncharacterized protein. (340 aa)
W5NXJ6_SHEEPUncharacterized protein. (265 aa)
FAM71F2Family with sequence similarity 71 member F2. (300 aa)
FAM71F1Family with sequence similarity 71 member F1. (343 aa)
CCDC136Coiled-coil domain containing 136. (1208 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1268 aa)
PSME4Proteasome activator subunit 4. (1729 aa)
SPINK1Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens. (79 aa)
EFCAB9EF-hand calcium binding domain 9. (215 aa)
LOC101115386Histone domain-containing protein. (136 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase. Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase. Isoform FSH-R3 may be involved in calcium signaling. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (By similarity). (656 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (556 aa)
RSPH3Radial spoke head 3. (491 aa)
GALNTL5Polypeptide N-acetylgalactosaminyltransferase like 5. (448 aa)
W5P3Y5_SHEEPUncharacterized protein. (125 aa)
PACRGUncharacterized protein. (125 aa)
LOC101110332Kazal-like domain-containing protein. (84 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
PACRGLParkin coregulated like. (253 aa)
CATSPER4Cation channel sperm associated 4. (468 aa)
W5P5A8_SHEEPHistone domain-containing protein. (136 aa)
DPY19L2Dpy-19 like 2. (773 aa)
CATSPERECatsper channel auxiliary subunit epsilon. (952 aa)
CFAP97D1CFAP97 domain containing 1. (164 aa)
DEFB1Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility. (64 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (349 aa)
RFX2Regulatory factor X2. (720 aa)
TNP2Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. (136 aa)
CATSPERZUncharacterized protein. (132 aa)
CFAP43Cilia and flagella associated protein 43. (1668 aa)
IQCF1IQ motif containing F1. (210 aa)
IQCF5IQ motif containing F5. (177 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (760 aa)
CELF1CUGBP Elav-like family member 1. (517 aa)
DLDDihydrolipoyl dehydrogenase. (509 aa)
PITHD1PITH domain-containing protein. (118 aa)
ING2Inhibitor of growth protein. (283 aa)
W5PBC1_SHEEPUncharacterized protein. (395 aa)
CATSPERDCation channel sperm associated auxiliary subunit delta. (781 aa)
ZMYND15Zinc finger MYND-type containing 15. (777 aa)
CABYRCalcium binding tyrosine phosphorylation regulated. (454 aa)
CFAP58Cilia and flagella associated protein 58. (872 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (280 aa)
MEIG1Meiosis/spermiogenesis associated 1. (88 aa)
GK2Glycerol kinase 2; Belongs to the FGGY kinase family. (554 aa)
FNDC3AFibronectin type III domain containing 3A. (1197 aa)
DMRTC2DMRT like family C2. (414 aa)
HOOK1Hook microtubule tethering protein 1. (733 aa)
BSP5Uncharacterized protein. (154 aa)
ENSOARP00000009186annotation not available (154 aa)
rsvp14Seminal vesicles 14 kDa protein. (129 aa)
OSBP2Oxysterol binding protein 2. (681 aa)
TPGS1Tubulin polyglutamylase complex subunit 1. (302 aa)
MEIOCMeiosis specific with coiled-coil domain. (963 aa)
CEP57Centrosomal protein 57. (499 aa)
PVRPVR cell adhesion molecule. (394 aa)
NECTIN2Nectin cell adhesion molecule 2. (526 aa)
LOC101108931Histone H3; Belongs to the histone H3 family. (136 aa)
PLA2G3Phospholipase A2 group III. (516 aa)
KLC3Kinesin light chain 3. (495 aa)
SEPTIN14Septin 14; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (425 aa)
AKAP4A-kinase anchoring protein 4. (860 aa)
TMF1TATA element modulatory factor 1. (1088 aa)
SIX5SIX homeobox 5. (471 aa)
RSPH6ARadial spoke head 6 homolog A. (710 aa)
MKKSMcKusick-Kaufman syndrome. (572 aa)
W5PLE7_SHEEPPITH domain-containing protein. (183 aa)
ARMC2Armadillo repeat containing 2. (865 aa)
RSPH1Radial spoke head component 1. (308 aa)
CATSPER2Cation channel sperm associated 2. (538 aa)
TTC26Tetratricopeptide repeat domain 26. (554 aa)
ABHD2Abhydrolase domain containing 2. (425 aa)
W5PNU4_SHEEPHistone H3; Belongs to the histone H3 family. (136 aa)
SPEF2Sperm flagellar 2. (1819 aa)
W5PPC7_SHEEPUncharacterized protein. (96 aa)
BSPH1Binder of sperm protein homolog 1. (91 aa)
ELSPBP1Epididymal sperm binding protein 1. (223 aa)
CFAP157Cilia and flagella associated protein 157. (539 aa)
DDX25DEAD-box helicase 25. (484 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (701 aa)
CFAP69Cilia and flagella associated protein 69. (942 aa)
CIB1Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] (217 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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