STRINGSTRING
ING2 ING2 EIF2B4 EIF2B4 REC8 REC8 W5QCU2_SHEEP W5QCU2_SHEEP TBC1D20 TBC1D20 PDGFRA PDGFRA STAT5B STAT5B RAD21L1 RAD21L1 ATRX ATRX TFAP2C TFAP2C NR0B1 NR0B1 H3F3A H3F3A KLHL10 KLHL10 W5Q8C3_SHEEP W5Q8C3_SHEEP SALL1 SALL1 INHBA INHBA PCYT1B PCYT1B BMPR1B BMPR1B ZFX ZFX W5Q6D1_SHEEP W5Q6D1_SHEEP W5Q6C7_SHEEP W5Q6C7_SHEEP OSR1 OSR1 FGF8 FGF8 W5Q5H1_SHEEP W5Q5H1_SHEEP PRDX4 PRDX4 CRKL CRKL WT1 WT1 GFRA1 GFRA1 BRIP1 BRIP1 KITLG KITLG DMC1 DMC1 LHX9 LHX9 WNT5A WNT5A LOC101111942 LOC101111942 KIF18A KIF18A ADAMTS1 ADAMTS1 TAF4 TAF4 HESX1 HESX1 TCF21 TCF21 FANCA FANCA AR AR SOX8 SOX8 DMRTA1 DMRTA1 AMH AMH BCL2L11 BCL2L11 RARA RARA AFP AFP GATA3 GATA3 SOX9 SOX9 CCDC182 CCDC182 FGF9 FGF9 NR5A1 NR5A1 CEBPB CEBPB DMRT1 DMRT1 MSH4 MSH4 LHX8 LHX8 COL9A3 COL9A3 FANCG FANCG GATA1 GATA1 KDM5A KDM5A ATM ATM RXFP2 RXFP2 W5PNU4_SHEEP W5PNU4_SHEEP BRCA2 BRCA2 IRX5 IRX5 TGFBR1 TGFBR1 SRD5A2 SRD5A2 VGF VGF FOXO3 FOXO3 WDR19 WDR19 TMF1 TMF1 NKX3-1 NKX3-1 PATZ1 PATZ1 W5PJQ6_SHEEP W5PJQ6_SHEEP ERCC1 ERCC1 ACVR2A ACVR2A HYAL3 HYAL3 HOXA9 HOXA9 LOC101108931 LOC101108931 BMP15 BMP15 ADAM29 ADAM29 LOC101111693 LOC101111693 EIF2S2 EIF2S2 SF1 SF1 UBE3A UBE3A TNFAIP6 TNFAIP6 GATA6 GATA6 FST FST NKX2-1 NKX2-1 SAFB2 SAFB2 SOD1 SOD1 PLEKHA1 PLEKHA1 GAS2 GAS2 FOXL2 FOXL2 LRRC6 LRRC6 SGPL1 SGPL1 BCL2 BCL2 W5P8A8_SHEEP W5P8A8_SHEEP CSMD1 CSMD1 RDH10 RDH10 W5P5A8_SHEEP W5P5A8_SHEEP ATN1 ATN1 MSH2 MSH2 LFNG LFNG SIRT1 SIRT1 SLIT2 SLIT2 LOC101110970 LOC101110970 LOC101115991 LOC101115991 LOC101115734 LOC101115734 SMAD4 SMAD4 LHCGR LHCGR ARID5B ARID5B FSHR FSHR SOD1-2 SOD1-2 FZD4 FZD4 ZFP42 ZFP42 ZNF830 ZNF830 LOC101115386 LOC101115386 LRP2 LRP2 GPR149 GPR149 ESR1 ESR1 IMMP2L IMMP2L NUPR1 NUPR1 TIPARP TIPARP SLIT3 SLIT3 PTX3 PTX3 CITED2 CITED2 SFRP1 SFRP1 REN REN LOC101107061 LOC101107061 NANOG NANOG WDR48 WDR48 RAB13 RAB13 SFRP2 SFRP2 ENSOARP00000001737 ENSOARP00000001737 DHH DHH EIF2B2 EIF2B2 SCAPER SCAPER NRIP1 NRIP1 ADAM21 ADAM21 KDR KDR W5NSF5_SHEEP W5NSF5_SHEEP STAT5A STAT5A ADGRG1 ADGRG1 NUP107 NUP107 LOC101105265 LOC101105265 KIT KIT SPO11 SPO11 ADAM20 ADAM20 SIX4 SIX4 ARID4A ARID4A YBX3 YBX3 EIF2B5 EIF2B5 PTPRN PTPRN WNT2B WNT2B AGO4 AGO4 CSMD2 CSMD2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ING2Inhibitor of growth protein. (283 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (565 aa)
REC8REC8 meiotic recombination protein. (592 aa)
W5QCU2_SHEEPUncharacterized protein. (148 aa)
TBC1D20TBC1 domain family member 20. (351 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
RAD21L1RAD21 cohesin complex component like 1. (554 aa)
ATRXATRX chromatin remodeler. (2451 aa)
TFAP2CTranscription factor AP-2 gamma. (358 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (377 aa)
H3F3AHistone H3.3. (136 aa)
KLHL10Kelch like family member 10. (608 aa)
W5Q8C3_SHEEPUncharacterized protein. (722 aa)
SALL1Spalt like transcription factor 1. (1295 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (425 aa)
PCYT1BPhosphate cytidylyltransferase 1, choline, beta. (329 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa)
ZFXUncharacterized protein. (800 aa)
W5Q6D1_SHEEPUncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (83 aa)
W5Q6C7_SHEEPUncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (82 aa)
OSR1Odd-skipped related transcription factor 1. (262 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
W5Q5H1_SHEEPUncharacterized protein. (335 aa)
PRDX4Peroxiredoxin 4. (273 aa)
CRKLCRK like proto-oncogene, adaptor protein. (305 aa)
WT1WT1 transcription factor. (450 aa)
GFRA1GDNF family receptor alpha 1. (335 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (995 aa)
KITLGSoluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] (274 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
LHX9LIM homeobox 9. (402 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
LOC101111942Uncharacterized protein. (739 aa)
KIF18AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (895 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (968 aa)
TAF4TATA-box binding protein associated factor 4. (770 aa)
HESX1HESX homeobox 1. (185 aa)
TCF21Transcription factor 21. (263 aa)
FANCAFA complementation group A. (1431 aa)
ARAndrogen receptor. (881 aa)
SOX8SRY-box transcription factor 8. (338 aa)
DMRTA1DMRT like family A1. (490 aa)
AMHAMH_N domain-containing protein. (213 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (195 aa)
RARARetinoic acid receptor alpha. (453 aa)
AFPAlpha fetoprotein. (610 aa)
GATA3GATA binding protein 3. (322 aa)
SOX9SRY-box transcription factor 9. (383 aa)
CCDC182Coiled-coil domain containing 182. (164 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (439 aa)
CEBPBBZIP domain-containing protein. (126 aa)
DMRT1Doublesex and mab-3 related transcription factor 1. (332 aa)
MSH4MutS homolog 4. (935 aa)
LHX8LIM homeobox 8. (372 aa)
COL9A3Uncharacterized protein. (687 aa)
FANCGFA complementation group G. (569 aa)
GATA1Uncharacterized protein. (406 aa)
KDM5ALysine demethylase 5A. (1694 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
RXFP2Relaxin family peptide receptor 2. (754 aa)
W5PNU4_SHEEPHistone H3; Belongs to the histone H3 family. (136 aa)
BRCA2BRCA2 DNA repair associated. (3427 aa)
IRX5Iroquois homeobox 5. (430 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
VGFUncharacterized protein. (230 aa)
FOXO3Fork-head domain-containing protein. (473 aa)
WDR19WD repeat domain 19. (1342 aa)
TMF1TATA element modulatory factor 1. (1088 aa)
NKX3-1NK3 homeobox 1. (246 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (628 aa)
W5PJQ6_SHEEPUncharacterized protein. (2013 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (299 aa)
ACVR2AActivin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
HYAL3Hyaluronidase. (419 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
LOC101108931Histone H3; Belongs to the histone H3 family. (136 aa)
BMP15Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (402 aa)
ADAM29ADAM metallopeptidase domain 29. (725 aa)
LOC101111693Uncharacterized protein. (752 aa)
EIF2S2Eukaryotic translation initiation factor 2 subunit beta. (333 aa)
SF1Splicing factor 1. (571 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (875 aa)
TNFAIP6TNF alpha induced protein 6. (280 aa)
GATA6GATA binding protein 6. (613 aa)
FSTFollistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (344 aa)
NKX2-1NK2 homeobox 1. (400 aa)
SAFB2Scaffold attachment factor B2. (915 aa)
SOD1Superoxide dismutase 1. (152 aa)
PLEKHA1Pleckstrin homology domain containing A1. (404 aa)
GAS2Growth arrest specific 2. (314 aa)
FOXL2Fork-head domain-containing protein. (158 aa)
LRRC6Leucine rich repeat containing 6. (473 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
BCL2BCL2 apoptosis regulator. (139 aa)
W5P8A8_SHEEPUncharacterized protein. (81 aa)
CSMD1CUB and Sushi multiple domains 1. (3047 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (301 aa)
W5P5A8_SHEEPHistone domain-containing protein. (136 aa)
ATN1Atrophin 1. (1168 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (351 aa)
SIRT1Sirtuin 1. (610 aa)
SLIT2Slit guidance ligand 2. (1402 aa)
LOC101110970Uncharacterized protein. (854 aa)
LOC101115991Uncharacterized protein. (806 aa)
LOC101115734Uncharacterized protein. (815 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. (700 aa)
ARID5BAT-rich interaction domain 5B. (1190 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. The activity of isoform FSH-R1 is mediated by G proteins which activate adenylate cyclase. Isoform FSH-R2 and isoform FSH-R3 also bind FSH, but this does not result in activation of adenylate cyclase. Isoform FSH-R3 may be involved in calcium signaling. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways (By similarity). (656 aa)
SOD1-2Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (539 aa)
ZFP42ZFP42 zinc finger protein. (300 aa)
ZNF830Zinc finger protein 830. (373 aa)
LOC101115386Histone domain-containing protein. (136 aa)
LRP2LDL receptor related protein 2. (4665 aa)
GPR149G protein-coupled receptor 149. (742 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (495 aa)
IMMP2LUncharacterized protein. (80 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (656 aa)
SLIT3Slit guidance ligand 3. (1335 aa)
PTX3Pentraxin 3. (380 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (263 aa)
SFRP1Secreted frizzled related protein 1. (256 aa)
RENRenin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. (406 aa)
LOC101107061SCHIP-1 domain-containing protein. (240 aa)
NANOGHomeobox domain-containing protein. (301 aa)
WDR48WD repeat domain 48. (677 aa)
RAB13Uncharacterized protein. (241 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
ENSOARP00000001737annotation not available (301 aa)
DHHUncharacterized protein. (301 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (354 aa)
SCAPERS-phase cyclin A associated protein in the ER. (1400 aa)
NRIP1Nuclear receptor interacting protein 1. (1156 aa)
ADAM21ADAM metallopeptidase domain 21. (718 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
W5NSF5_SHEEPUncharacterized protein. (740 aa)
STAT5ASignal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. (788 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (690 aa)
NUP107Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (937 aa)
LOC101105265Uncharacterized protein. (351 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
SPO11SPO11 initiator of meiotic double stranded breaks. (395 aa)
ADAM20ADAM metallopeptidase domain 20. (744 aa)
SIX4SIX homeobox 4. (768 aa)
ARID4AAT-rich interaction domain 4A. (1258 aa)
YBX3Y-box binding protein 3. (295 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (671 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (954 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (871 aa)
CSMD2CUB and Sushi multiple domains 2. (3465 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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