STRINGSTRING
FERMT2 FERMT2 BMP4 BMP4 IL1B IL1B EZH2 EZH2 TGFB1 TGFB1 LEF1 LEF1 W5QBZ2_SHEEP W5QBZ2_SHEEP BMP2 BMP2 SMAD3 SMAD3 W5QA57_SHEEP W5QA57_SHEEP BMP7 BMP7 GCNT2 GCNT2 AXIN2 AXIN2 ALX1 ALX1 BAMBI BAMBI TGFBR2 TGFBR2 CRB2 CRB2 SNAI1 SNAI1 TCF7L2 TCF7L2 W5PRT1_SHEEP W5PRT1_SHEEP IL6 IL6 BCL9L BCL9L GLIPR2 GLIPR2 TGFB2 TGFB2 ENG ENG TGFBR1 TGFBR1 W5PMM1_SHEEP W5PMM1_SHEEP PDPN PDPN EMP2 EMP2 TBX20 TBX20 COL1A1 COL1A1 WWTR1 WWTR1 SMAD4 SMAD4 ZNF703 ZNF703 NOTCH1 NOTCH1 SMAD2 SMAD2 CTNNB1 CTNNB1 MTOR MTOR TGFB3 TGFB3 W5PM90_SHEEP W5PM90_SHEEP LOXL2 LOXL2 TGFB1I1 TGFB1I1 DAB2 DAB2 LRG1 LRG1 W5PGU2_SHEEP W5PGU2_SHEEP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FERMT2Fermitin family member 2. (687 aa)
BMP4TGF_BETA_2 domain-containing protein. (409 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (514 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
W5QBZ2_SHEEPUncharacterized protein. (289 aa)
BMP2Bone morphogenetic protein 2. (425 aa)
SMAD3Mothers against decapentaplegic homolog. (316 aa)
W5QA57_SHEEPMH1 domain-containing protein. (106 aa)
BMP7Bone morphogenetic protein 7. (397 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
AXIN2Axin 2. (820 aa)
ALX1ALX homeobox 1. (326 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family. (235 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
CRB2Crumbs cell polarity complex component 2. (1220 aa)
SNAI1Snail family transcriptional repressor 1. (348 aa)
TCF7L2Transcription factor 7 like 2. (454 aa)
W5PRT1_SHEEPCTNNB1_binding domain-containing protein. (103 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
BCL9LBCL9 like. (1422 aa)
GLIPR2SCP domain-containing protein; Belongs to the CRISP family. (151 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
ENGEndoglin. (649 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
W5PMM1_SHEEPUncharacterized protein. (249 aa)
PDPNUncharacterized protein. (168 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
TBX20T-box transcription factor 20. (399 aa)
COL1A1Collagen type I alpha 1 chain. (1474 aa)
WWTR1WW domain containing transcription regulator 1. (392 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ZNF703Uncharacterized protein. (112 aa)
NOTCH1Notch receptor 1. (2008 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CTNNB1Catenin beta 1. (782 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
W5PM90_SHEEPUncharacterized protein. (265 aa)
LOXL2Lysyl oxidase like 2. (762 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (460 aa)
DAB2DAB adaptor protein 2. (810 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (353 aa)
W5PGU2_SHEEPSCP domain-containing protein. (154 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.