70 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPSB1	SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa)
	DAW1	Dynein assembly factor with WD repeats 1. (415 aa)
	FBXO45	F-box protein 45. (287 aa)
	FBXO48	F-box protein 48. (175 aa)
	AMN1	Antagonist of mitotic exit network 1 homolog. (258 aa)
	ARIH1	RBR-type E3 ubiquitin transferase. (512 aa)
	FBXL13	F-box and leucine rich repeat protein 13. (871 aa)
	FBXL17	Uncharacterized protein. (303 aa)
	CUL1	CULLIN_2 domain-containing protein; Belongs to the cullin family. (759 aa)
	CCNF	Cyclin F; Belongs to the cyclin family. (785 aa)
	FBXO7	F-box protein 7. (527 aa)
	TRAF7	TNF receptor associated factor 7. (674 aa)
	W5Q851_SHEEP	B30.2/SPRY domain-containing protein. (162 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (748 aa)
	FBXW4	F-box and WD repeat domain containing 4. (432 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (508 aa)
	SPSB3	SplA/ryanodine receptor domain and SOCS box containing 3. (355 aa)
	FBXL3	F-box domain-containing protein. (437 aa)
	FBXL2	F-box and leucine rich repeat protein 2. (441 aa)
	FBXO9	F-box protein 9. (452 aa)
	Fbxl21	F-box/LRR-repeat protein 21; Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock r [...] (581 aa)
	FBXL6	F-box and leucine rich repeat protein 6. (606 aa)
	CACYBP	Calcyclin binding protein. (230 aa)
	FBXL16	F-box and leucine rich repeat protein 16. (419 aa)
	W5PVK7_SHEEP	F-box domain-containing protein. (479 aa)
	FBXO25	F-box protein 25. (367 aa)
	FBXL12	F-box and leucine rich repeat protein 12. (336 aa)
	FBXL7	F-box and leucine rich repeat protein 7. (425 aa)
	FBH1	F-box DNA helicase 1. (1046 aa)
	FBXO42	F-box protein 42. (820 aa)
	FBXL4	F-box and leucine rich repeat protein 4. (621 aa)
	FBXO31	F-box protein 31. (448 aa)
	CMIP-2	Uncharacterized protein. (85 aa)
	SKP2	F-box domain-containing protein. (476 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (780 aa)
	FBXL20	F-box and leucine rich repeat protein 20. (527 aa)
	FBXO32	F-box protein 32. (355 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1379 aa)
	FBXL5	F-box and leucine rich repeat protein 5. (692 aa)
	FBXO4	F-box protein 4. (326 aa)
	FBXO33	F-box protein 33. (538 aa)
	CMIP	C-Maf inducing protein. (683 aa)
	W5PEG8_SHEEP	CULLIN_2 domain-containing protein; Belongs to the cullin family. (766 aa)
	FBXL19	F-box and leucine rich repeat protein 19. (630 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	DMAC2	Distal membrane arm assembly complex 2. (264 aa)
	SPSB4	SplA/ryanodine receptor domain and SOCS box containing 4. (204 aa)
	W5P9Y2_SHEEP	Uncharacterized protein. (282 aa)
	NCCRP1	Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish). (253 aa)
	W5P7I7_SHEEP	Uncharacterized protein. (302 aa)
	W5P7I2_SHEEP	Uncharacterized protein. (276 aa)
	W5P7H3_SHEEP	Uncharacterized protein. (279 aa)
	W5P7G5_SHEEP	Uncharacterized protein. (284 aa)
	FBXO17	F-box protein 17. (161 aa)
	FBXW8	F-box and WD repeat domain containing 8. (507 aa)
	FBXO15	F-box protein 15. (459 aa)
	FBXW7	F-box and WD repeat domain containing 7. (709 aa)
	FBXW11	F-box and WD repeat domain containing 11. (531 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	FBXL18	F-box and leucine rich repeat protein 18. (725 aa)
	W5NXW4_SHEEP	Uncharacterized protein. (480 aa)
	FBXL8	F-box domain-containing protein. (378 aa)
	W5NT00_SHEEP	Uncharacterized protein. (212 aa)
	FBXO2	F-box protein 2. (299 aa)
	FBXW5	WD_REPEATS_REGION domain-containing protein. (87 aa)
	LOC101112585	Uncharacterized protein. (255 aa)
	TRIM21	Tripartite motif containing 21. (468 aa)
	FBXO6	F-box protein 6. (302 aa)
	FBXO39	F-box protein 39. (443 aa)
	TMEM183A	Transmembrane protein 183A. (376 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMN1	CUL1	ENSOARP00000020842	ENSOARP00000020109	Antagonist of mitotic exit network 1 homolog.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.474
AMN1	W5PEG8_SHEEP	ENSOARP00000020842	ENSOARP00000008832	Antagonist of mitotic exit network 1 homolog.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.474
ARIH1	CUL1	ENSOARP00000020363	ENSOARP00000020109	RBR-type E3 ubiquitin transferase.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.832
ARIH1	CUL2	ENSOARP00000020363	ENSOARP00000018280	RBR-type E3 ubiquitin transferase.	Cullin 2; Belongs to the cullin family.	0.553
ARIH1	SKP2	ENSOARP00000020363	ENSOARP00000011732	RBR-type E3 ubiquitin transferase.	F-box domain-containing protein.	0.526
ARIH1	W5PEG8_SHEEP	ENSOARP00000020363	ENSOARP00000008832	RBR-type E3 ubiquitin transferase.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.820
ARIH1	W5PVK7_SHEEP	ENSOARP00000020363	ENSOARP00000014490	RBR-type E3 ubiquitin transferase.	F-box domain-containing protein.	0.455
BTRC	CCNF	ENSOARP00000017683	ENSOARP00000019781	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cyclin F; Belongs to the cyclin family.	0.424
BTRC	CUL1	ENSOARP00000017683	ENSOARP00000020109	Beta-transducin repeat containing E3 ubiquitin protein ligase.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.993
BTRC	FBXO2	ENSOARP00000017683	ENSOARP00000001236	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 2.	0.931
BTRC	FBXO4	ENSOARP00000017683	ENSOARP00000009519	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 4.	0.913
BTRC	FBXW11	ENSOARP00000017683	ENSOARP00000003880	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 11.	0.969
BTRC	FBXW4	ENSOARP00000017683	ENSOARP00000018044	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 4.	0.553
BTRC	FBXW7	ENSOARP00000017683	ENSOARP00000004434	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 7.	0.942
BTRC	SKP2	ENSOARP00000017683	ENSOARP00000011732	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box domain-containing protein.	0.938
BTRC	USP47	ENSOARP00000017683	ENSOARP00000010310	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family.	0.549
BTRC	W5PEG8_SHEEP	ENSOARP00000017683	ENSOARP00000008832	Beta-transducin repeat containing E3 ubiquitin protein ligase.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.920
BTRC	W5PVK7_SHEEP	ENSOARP00000017683	ENSOARP00000014490	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box domain-containing protein.	0.406
CCNF	BTRC	ENSOARP00000019781	ENSOARP00000017683	Cyclin F; Belongs to the cyclin family.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.424
CCNF	CKS1B	ENSOARP00000019781	ENSOARP00000003501	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.607