STRINGSTRING
GOT1L1 GOT1L1 PLPBP PLPBP CRABP1 CRABP1 CSAD CSAD TKT TKT TTPA TTPA ABCA4 ABCA4 W5Q6U0_SHEEP W5Q6U0_SHEEP P3H4 P3H4 PLOD1 PLOD1 SLC46A1 SLC46A1 AGXT AGXT PAM PAM OGFOD1 OGFOD1 TPK1 TPK1 SHMT1 SHMT1 VDR VDR P3H1 P3H1 P3H2 P3H2 PYGL PYGL W5NRG4_SHEEP W5NRG4_SHEEP OPN4 OPN4 PIGS PIGS MARC2 MARC2 MARC1 MARC1 GLDC GLDC ALB ALB AFM AFM GCAT GCAT RHO RHO DDC DDC NFS1 NFS1 GADL1 GADL1 DHTKD1 DHTKD1 OGDH OGDH KYAT3 KYAT3 PLOD3 PLOD3 HACL1 HACL1 SRR SRR P4HA2 P4HA2 W5Q1I4_SHEEP W5Q1I4_SHEEP CRTAP CRTAP GPT2 GPT2 FTCDNL1 FTCDNL1 P4HTM P4HTM CYP27C1 CYP27C1 OGFOD3 OGFOD3 RBP5 RBP5 FOLR2 FOLR2 GAD2 GAD2 LACB_SHEEP LACB_SHEEP W5P546_SHEEP W5P546_SHEEP ABAT ABAT S100G S100G FTCD FTCD GC GC SLC19A1 SLC19A1 METTL26 METTL26 TCN1 TCN1 GOT1 GOT1 PSAT1 PSAT1 CBLIF CBLIF MMUT MMUT OPN5 OPN5 CTH CTH LMBRD1 LMBRD1 AGXT2 AGXT2 RLBP1 RLBP1 CBS CBS ISM1 ISM1 SPTLC3 SPTLC3 CALB1 CALB1 OAT OAT CUBN CUBN KYNU KYNU P4HA3 P4HA3 W5PHB0_SHEEP W5PHB0_SHEEP PYGM PYGM THNSL2 THNSL2 HDC HDC TCN2 TCN2 PDXDC1 PDXDC1 SPTLC1 SPTLC1 PNPO PNPO W5PCA2_SHEEP W5PCA2_SHEEP ETNPPL ETNPPL SDS SDS P4HA1 P4HA1 SHMT2 SHMT2 PYGB PYGB OGFOD2 OGFOD2 EGLN2 EGLN2 CDCP2 CDCP2 RBP1 RBP1 EGLN3 EGLN3 CYP2R1 CYP2R1 PHYKPL PHYKPL SGPL1 SGPL1 ALAS1 ALAS1 CRABP2 CRABP2 P3H3 P3H3 W5P775_SHEEP W5P775_SHEEP W5P6Y5_SHEEP W5P6Y5_SHEEP FOLR1 FOLR1 FOLR3 FOLR3 STRA6 STRA6 TAT TAT MTR MTR THNSL1 THNSL1 EGLN1 EGLN1 RBP4 RBP4 W5NYJ5_SHEEP W5NYJ5_SHEEP FASN FASN PANK3 PANK3 AGXT-2 AGXT-2 MOCOS MOCOS TKTL1 TKTL1 ALAS2 ALAS2 PLOD2 PLOD2 SPTLC2 SPTLC2 GPT GPT GAD1 GAD1 OGDHL OGDHL W5NVS0_SHEEP W5NVS0_SHEEP GOT2 GOT2 MMACHC MMACHC ACCS ACCS ACCSL ACCSL RBP3 RBP3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (461 aa)
PLPBPPyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (276 aa)
CRABP1Cellular retinoic acid binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
CSADUncharacterized protein. (507 aa)
TKTTransketolase. (623 aa)
TTPAAlpha-tocopherol transfer protein. (282 aa)
ABCA4ATP binding cassette subfamily A member 4. (2281 aa)
W5Q6U0_SHEEPCarrier domain-containing protein. (2372 aa)
P3H4Prolyl 3-hydroxylase family member 4 (non-enzymatic). (285 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (701 aa)
SLC46A1Solute carrier family 46 member 1. (398 aa)
AGXTSerine--pyruvate aminotransferase. (401 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (973 aa)
OGFOD12-oxoglutarate and iron dependent oxygenase domain containing 1. (545 aa)
TPK1Thiamine pyrophosphokinase; Belongs to the thiamine pyrophosphokinase family. (243 aa)
SHMT1Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (486 aa)
VDRVitamin D receptor. (424 aa)
P3H1Prolyl 3-hydroxylase 1. (736 aa)
P3H2Prolyl 3-hydroxylase 2. (708 aa)
PYGLGlycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). (779 aa)
W5NRG4_SHEEPADH_zinc_N domain-containing protein. (128 aa)
OPN4Opsin 4; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (462 aa)
PIGSPhosphatidylinositol glycan anchor biosynthesis class S. (555 aa)
MARC2Mitochondrial amidoxime reducing component 2. (334 aa)
MARC1MOSC domain-containing protein. (333 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1025 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
AFMAfamin. (608 aa)
GCATGlycine C-acetyltransferase. (430 aa)
RHORhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (348 aa)
DDCDopa decarboxylase. (543 aa)
NFS1Aminotran_5 domain-containing protein. (453 aa)
GADL1Glutamate decarboxylase like 1. (449 aa)
DHTKD1Dehydrogenase E1 and transketolase domain containing 1. (921 aa)
OGDHOxoglutarate dehydrogenase. (1023 aa)
KYAT3Kynurenine aminotransferase 3. (457 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (755 aa)
HACL12-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family. (582 aa)
SRRSerine racemase. (339 aa)
P4HA2Prolyl 4-hydroxylase subunit alpha 2. (538 aa)
W5Q1I4_SHEEPAminotran_1_2 domain-containing protein. (269 aa)
CRTAPCartilage associated protein. (400 aa)
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
FTCDNL1FTCD_N domain-containing protein. (328 aa)
P4HTMProlyl 4-hydroxylase, transmembrane. (481 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (480 aa)
OGFOD32-oxoglutarate and iron dependent oxygenase domain containing 3. (315 aa)
RBP5Retinol binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
FOLR2Folate receptor beta. (255 aa)
GAD2Glutamate decarboxylase 2. (578 aa)
LACB_SHEEPBeta-lactoglobulin-1/B; Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule; Belongs to the calycin superfamily. Lipocalin family. (174 aa)
W5P546_SHEEPLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (182 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
S100GProtein S100; Belongs to the S-100 family. (79 aa)
FTCDFormimidoyltransferase cyclodeaminase. (540 aa)
GCGC vitamin D binding protein. (476 aa)
SLC19A1Solute carrier family 19 member 1. (508 aa)
METTL26Methyltransferase like 26. (206 aa)
TCN1Transcobalamin 1. (440 aa)
GOT1Aspartate aminotransferase. (413 aa)
PSAT1Phosphoserine aminotransferase. (396 aa)
CBLIFCobalamin binding intrinsic factor. (417 aa)
MMUTMethylmalonyl-CoA mutase. (755 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (377 aa)
CTHCystathionine gamma-lyase. (417 aa)
LMBRD1LMBR1 domain containing 1. (545 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
RLBP1Retinaldehyde binding protein 1. (338 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa)
ISM1Isthmin 1. (405 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (549 aa)
CALB1Calbindin 1. (262 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
CUBNCubilin. (3630 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (463 aa)
P4HA3Prolyl 4-hydroxylase subunit alpha 3. (547 aa)
W5PHB0_SHEEPAminotran_1_2 domain-containing protein. (428 aa)
PYGMGlycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
THNSL2Threonine synthase like 2. (485 aa)
HDCHistidine decarboxylase. (658 aa)
TCN2Transcobalamin 2. (437 aa)
PDXDC1Pyridoxal dependent decarboxylase domain containing 1. (790 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (475 aa)
PNPOPyridoxamine 5'-phosphate oxidase. (261 aa)
W5PCA2_SHEEPUncharacterized protein. (260 aa)
ETNPPLEthanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa)
SDSSerine dehydratase. (329 aa)
P4HA1Prolyl 4-hydroxylase subunit alpha 1. (534 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa)
PYGBGlycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (844 aa)
OGFOD22-oxoglutarate and iron dependent oxygenase domain containing 2. (350 aa)
EGLN2Egl-9 family hypoxia inducible factor 2. (407 aa)
CDCP2CUB domain containing protein 2. (488 aa)
RBP1Retinol binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (348 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (510 aa)
PHYKPL5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
ALAS15'-aminolevulinate synthase 1. (665 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
P3H3Prolyl 3-hydroxylase 3. (633 aa)
W5P775_SHEEPUncharacterized protein. (543 aa)
W5P6Y5_SHEEPUncharacterized protein. (118 aa)
FOLR1Folate_rec domain-containing protein. (257 aa)
FOLR3Folate_rec domain-containing protein. (264 aa)
STRA6Stimulated by retinoic acid 6. (744 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (456 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1268 aa)
THNSL1Threonine synthase like 1. (715 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (358 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (165 aa)
W5NYJ5_SHEEPCu2_monoox_C domain-containing protein. (278 aa)
FASNUncharacterized protein. (183 aa)
PANK3Pantothenate kinase 3. (370 aa)
AGXT-2Aminotran_5 domain-containing protein. (108 aa)
MOCOSMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (849 aa)
TKTL1Transketolase like 1. (622 aa)
ALAS25-aminolevulinate synthase. (587 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (841 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
GPTGlutamic--pyruvic transaminase. (535 aa)
GAD1Glutamate decarboxylase 1. (599 aa)
OGDHLOxoglutarate dehydrogenase like. (1013 aa)
W5NVS0_SHEEPADH_N domain-containing protein. (126 aa)
GOT2Aspartate aminotransferase. (430 aa)
MMACHCMetabolism of cobalamin associated C. (280 aa)
ACCS1-aminocyclopropane-1-carboxylate synthase homolog (inactive). (508 aa)
ACCSL1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like. (610 aa)
RBP3Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. (1286 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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