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GPT2 GPT2 W5Q1I4_SHEEP W5Q1I4_SHEEP GPT GPT SPTLC2 SPTLC2 AGXT-2 AGXT-2 THNSL1 THNSL1 TAT TAT GAD2 GAD2 PLPBP PLPBP GOT1L1 GOT1L1 ACCSL ACCSL ACCS ACCS GOT2 GOT2 GAD1 GAD1 CTH CTH PSAT1 PSAT1 GOT1 GOT1 MARC2 MARC2 HDC HDC THNSL2 THNSL2 PYGL PYGL SHMT1 SHMT1 SRR SRR ABAT ABAT SHMT2 SHMT2 PYGB PYGB PHYKPL PHYKPL SGPL1 SGPL1 ALAS1 ALAS1 MARC1 MARC1 KYAT3 KYAT3 GADL1 GADL1 NFS1 NFS1 DDC DDC GCAT GCAT ALB ALB GLDC GLDC SDS SDS ETNPPL ETNPPL W5PCA2_SHEEP W5PCA2_SHEEP PNPO PNPO SPTLC1 SPTLC1 W5P775_SHEEP W5P775_SHEEP PDXDC1 PDXDC1 PYGM PYGM W5PHB0_SHEEP W5PHB0_SHEEP KYNU KYNU OAT OAT SPTLC3 SPTLC3 ISM1 ISM1 CBS CBS AGXT2 AGXT2 ALAS2 ALAS2 MOCOS MOCOS AGXT AGXT CSAD CSAD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
W5Q1I4_SHEEPAminotran_1_2 domain-containing protein. (269 aa)
GPTGlutamic--pyruvic transaminase. (535 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
AGXT-2Aminotran_5 domain-containing protein. (108 aa)
THNSL1Threonine synthase like 1. (715 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (456 aa)
GAD2Glutamate decarboxylase 2. (578 aa)
PLPBPPyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (276 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (461 aa)
ACCSL1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like. (610 aa)
ACCS1-aminocyclopropane-1-carboxylate synthase homolog (inactive). (508 aa)
GOT2Aspartate aminotransferase. (430 aa)
GAD1Glutamate decarboxylase 1. (599 aa)
CTHCystathionine gamma-lyase. (417 aa)
PSAT1Phosphoserine aminotransferase. (396 aa)
GOT1Aspartate aminotransferase. (413 aa)
MARC2Mitochondrial amidoxime reducing component 2. (334 aa)
HDCHistidine decarboxylase. (658 aa)
THNSL2Threonine synthase like 2. (485 aa)
PYGLGlycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). (779 aa)
SHMT1Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (486 aa)
SRRSerine racemase. (339 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa)
PYGBGlycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (844 aa)
PHYKPL5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
ALAS15'-aminolevulinate synthase 1. (665 aa)
MARC1MOSC domain-containing protein. (333 aa)
KYAT3Kynurenine aminotransferase 3. (457 aa)
GADL1Glutamate decarboxylase like 1. (449 aa)
NFS1Aminotran_5 domain-containing protein. (453 aa)
DDCDopa decarboxylase. (543 aa)
GCATGlycine C-acetyltransferase. (430 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] (609 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1025 aa)
SDSSerine dehydratase. (329 aa)
ETNPPLEthanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa)
W5PCA2_SHEEPUncharacterized protein. (260 aa)
PNPOPyridoxamine 5'-phosphate oxidase. (261 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (475 aa)
W5P775_SHEEPUncharacterized protein. (543 aa)
PDXDC1Pyridoxal dependent decarboxylase domain containing 1. (790 aa)
PYGMGlycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
W5PHB0_SHEEPAminotran_1_2 domain-containing protein. (428 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (463 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (549 aa)
ISM1Isthmin 1. (405 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
ALAS25-aminolevulinate synthase. (587 aa)
MOCOSMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (849 aa)
AGXTSerine--pyruvate aminotransferase. (401 aa)
CSADUncharacterized protein. (507 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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