STRINGSTRING
LOC101112162 LOC101112162 EDNRB EDNRB PGLYRP3 PGLYRP3 PGLYRP4 PGLYRP4 ITIH4 ITIH4 ITIH3 ITIH3 HYAL4 HYAL4 W5NSU1_SHEEP W5NSU1_SHEEP LOC101101889 LOC101101889 W5NTB5_SHEEP W5NTB5_SHEEP ITIH1 ITIH1 EXT2 EXT2 SGSH SGSH CHST1 CHST1 HPSE HPSE PGLYRP2 PGLYRP2 GNS GNS CHPF2 CHPF2 CSGALNACT1 CSGALNACT1 CSGALNACT2 CSGALNACT2 HEXB HEXB XYLT2 XYLT2 DSEL DSEL B3GALT6 B3GALT6 B4GALT7 B4GALT7 PXYLP1 PXYLP1 W5PA09_SHEEP W5PA09_SHEEP CHST3 CHST3 NDST1 NDST1 TGFB1 TGFB1 BGN BGN HS3ST1 HS3ST1 B4GALNT4 B4GALNT4 EDNRA EDNRA NDST2 NDST2 SLC10A7 SLC10A7 TNFAIP6 TNFAIP6 DSE DSE CHSY1 CHSY1 IDS IDS HYAL2 HYAL2 HYAL1 HYAL1 HYAL3 HYAL3 EXT1 EXT1 EGFLAM EGFLAM XYLT1 XYLT1 PGLYRP1 PGLYRP1 HS3ST4 HS3ST4 HAS2 HAS2 LYVE1 LYVE1 UGDH UGDH B4GALNT3 B4GALNT3 CEMIP2 CEMIP2 MAMDC2 MAMDC2 LYG2 LYG2 ITIH5 ITIH5 ITIH2 ITIH2 CHST7 CHST7 HS2ST1 HS2ST1 HAS1 HAS1 ANGPT1 ANGPT1 IMPAD1 IMPAD1 NDNF NDNF CEMIP CEMIP B3GAT3 B3GAT3 DCN DCN IDUA IDUA HS3ST2 HS3ST2 W5Q4H2_SHEEP W5Q4H2_SHEEP LOC101115554 LOC101115554 CHSY3 CHSY3 W5Q5G9_SHEEP W5Q5G9_SHEEP CHST11 CHST11 ARSK ARSK CHST12 CHST12 NDST4 NDST4 CLN6 CLN6 GLCE GLCE CD44 CD44 HEXA HEXA B4GALT4 B4GALT4 CHPF CHPF CHST14 CHST14 B3GNT7 B3GNT7 W5QHY0_SHEEP W5QHY0_SHEEP IL1B IL1B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101112162Beta-hexosaminidase. (549 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (456 aa)
PGLYRP3Peptidoglycan recognition protein 3. (377 aa)
PGLYRP4Peptidoglycan recognition protein 4. (374 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain 4. (917 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain 3. (891 aa)
HYAL4Hyaluronidase. (481 aa)
W5NSU1_SHEEPHyaluronidase. (553 aa)
LOC101101889Hyaluronidase. (506 aa)
W5NTB5_SHEEPHyaluronidase. (552 aa)
ITIH1Inter-alpha-trypsin inhibitor heavy chain 1. (912 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (737 aa)
SGSHN-sulfoglucosamine sulfohydrolase. (622 aa)
CHST1Sulfotransferase; Belongs to the sulfotransferase 1 family. (411 aa)
HPSEHeparanase. (571 aa)
PGLYRP2Peptidoglycan recognition protein 2. (591 aa)
GNSN-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. (552 aa)
CHPF2Hexosyltransferase. (720 aa)
CSGALNACT1Hexosyltransferase. (527 aa)
CSGALNACT2Hexosyltransferase. (544 aa)
HEXBBeta-hexosaminidase. (540 aa)
XYLT2Xylosyltransferase 2. (864 aa)
DSELDermatan sulfate epimerase like. (993 aa)
B3GALT6Hexosyltransferase. (325 aa)
B4GALT7Uncharacterized protein. (327 aa)
PXYLP12-phosphoxylose phosphatase 1; Belongs to the histidine acid phosphatase family. (480 aa)
W5PA09_SHEEPSulfotransferase; Belongs to the sulfotransferase 1 family. (410 aa)
CHST3Sulfotransferase; Belongs to the sulfotransferase 1 family. (480 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (883 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (369 aa)
HS3ST1Sulfotransferase; Belongs to the sulfotransferase 1 family. (312 aa)
B4GALNT4Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (807 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
NDST2Uncharacterized protein. (879 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (328 aa)
TNFAIP6TNF alpha induced protein 6. (280 aa)
DSEDermatan sulfate epimerase. (1023 aa)
CHSY1Hexosyltransferase. (727 aa)
IDSSulfatase domain-containing protein. (420 aa)
HYAL2Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity). (476 aa)
HYAL1Hyaluronidase. (450 aa)
HYAL3Hyaluronidase. (419 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (748 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (1026 aa)
XYLT1Xylosyltransferase 1. (831 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (205 aa)
HS3ST4Sulfotransferase; Belongs to the sulfotransferase 1 family. (212 aa)
HAS2Hyaluronan synthase 2. (558 aa)
LYVE1Lymphatic vessel endothelial hyaluronan receptor 1. (322 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (494 aa)
B4GALNT3Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1005 aa)
CEMIP2Cell migration inducing hyaluronidase 2. (1385 aa)
MAMDC2MAM domain containing 2. (637 aa)
LYG2Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family. (212 aa)
ITIH5Inter-alpha-trypsin inhibitor heavy chain 5. (935 aa)
ITIH2Inter-alpha-trypsin inhibitor heavy chain 2. (946 aa)
CHST7Sulfotransferase; Belongs to the sulfotransferase 1 family. (366 aa)
HS2ST1Uncharacterized protein. (356 aa)
HAS1Hyaluronan synthase 1. (496 aa)
ANGPT1Angiopoietin 1. (485 aa)
IMPAD1Inositol monophosphatase domain containing 1. (430 aa)
NDNFNeuron derived neurotrophic factor. (573 aa)
CEMIPCell migration inducing hyaluronidase 1. (1361 aa)
B3GAT3Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family. (337 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
IDUAIduronidase alpha-L-. (496 aa)
HS3ST2Sulfotransferase; Belongs to the sulfotransferase 1 family. (221 aa)
W5Q4H2_SHEEPSulfotransferase; Belongs to the sulfotransferase 1 family. (275 aa)
LOC101115554Sulfotransferase; Belongs to the sulfotransferase 1 family. (464 aa)
CHSY3Hexosyltransferase. (524 aa)
W5Q5G9_SHEEPUncharacterized protein. (127 aa)
CHST11Carbohydrate sulfotransferase. (369 aa)
ARSKArylsulfatase family member K. (540 aa)
CHST12Carbohydrate sulfotransferase. (416 aa)
NDST4N-deacetylase and N-sulfotransferase 4. (873 aa)
CLN6Uncharacterized protein. (299 aa)
GLCEGlucuronic acid epimerase. (636 aa)
CD44CD44 molecule (Indian blood group). (705 aa)
HEXABeta-hexosaminidase. (529 aa)
B4GALT4Beta-1,4-galactosyltransferase 4. (344 aa)
CHPFHexosyltransferase. (775 aa)
CHST14Carbohydrate sulfotransferase. (373 aa)
B3GNT7Hexosyltransferase. (401 aa)
W5QHY0_SHEEPUncharacterized protein. (416 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (266 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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