STRINGSTRING
SMURF1 SMURF1 W5NPR2_SHEEP W5NPR2_SHEEP GOLGA4 GOLGA4 RPTOR RPTOR SFRP2 SFRP2 SYT2 SYT2 SFRP1 SFRP1 W5NWJ9_SHEEP W5NWJ9_SHEEP DDX3X DDX3X DDX49 DDX49 PSMD10 PSMD10 DERL2 DERL2 LGI1 LGI1 IST1 IST1 SMAD7 SMAD7 SEMA7A SEMA7A SLC44A4 SLC44A4 ADNP2 ADNP2 F2 F2 W5P3B7_SHEEP W5P3B7_SHEEP HPN HPN W5P3W8_SHEEP W5P3W8_SHEEP PRKN PRKN FGFR1OP FGFR1OP SYT4 SYT4 SUPV3L1 SUPV3L1 NEDD4L NEDD4L SRF SRF TRIM32 TRIM32 TWF2 TWF2 CRABP2 CRABP2 CPNE9 CPNE9 WNT3A WNT3A YAP1 YAP1 CDKN2AIP CDKN2AIP SPHK1 SPHK1 EXOSC2 EXOSC2 CXCL16 CXCL16 SEMA4D SEMA4D MEGF8 MEGF8 W5PD66_SHEEP W5PD66_SHEEP RASAL1 RASAL1 TEAD1 TEAD1 CDC42 CDC42 SLC25A33 SLC25A33 HDGFL2 HDGFL2 USP47 USP47 HYAL1 HYAL1 MTPN MTPN DSCAM DSCAM W5PK14_SHEEP W5PK14_SHEEP W5PK84_SHEEP W5PK84_SHEEP WNT3 WNT3 TGFBR1 TGFBR1 W5PNB9_SHEEP W5PNB9_SHEEP CRYAA CRYAA NCBP1 NCBP1 ZFYVE27 ZFYVE27 SYT17 SYT17 TGFB2 TGFB2 ERBB2 ERBB2 LIMK1 LIMK1 CIB1 CIB1 ARMC12 ARMC12 FXN FXN DBNL DBNL CDKL5 CDKL5 EGFR EGFR CPNE5 CPNE5 KDM2B KDM2B NOL12 NOL12 SYT3 SYT3 LPAR3 LPAR3 EDN1 EDN1 EXOSC9 EXOSC9 PLAA PLAA N6AMT1 N6AMT1 SYT1 SYT1 CDH4 CDH4 ADAM17 ADAM17 EXOSC4 EXOSC4 UNC13A UNC13A IGF1 IGF1 TRPV2 TRPV2 KLHL22 KLHL22 ISLR ISLR BMPR2 BMPR2 SHTN1 SHTN1 SFN SFN W5QAV3_SHEEP W5QAV3_SHEEP EFNA5 EFNA5 TAF9B TAF9B CSNK2A1 CSNK2A1 FN1 FN1 MMP14 MMP14 UCN UCN NGF NGF COMMD5 COMMD5 MFSD2A MFSD2A INO80 INO80 MAP3K13 MAP3K13 EIF4G1 EIF4G1 W5QHQ2_SHEEP W5QHQ2_SHEEP ADAM10 ADAM10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMURF1E3 ubiquitin-protein ligase. (758 aa)
W5NPR2_SHEEPUncharacterized protein. (432 aa)
GOLGA4Golgin A4. (2251 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1388 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
SYT2C2 domain-containing protein. (89 aa)
SFRP1Secreted frizzled related protein 1. (256 aa)
W5NWJ9_SHEEPUncharacterized protein. (87 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (661 aa)
DDX49Helicase C-terminal domain-containing protein. (135 aa)
PSMD10ANK_REP_REGION domain-containing protein. (192 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
LGI1Leucine rich glioma inactivated 1. (640 aa)
IST1IST1 factor associated with ESCRT-III. (377 aa)
SMAD7MH2 domain-containing protein. (257 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (614 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (711 aa)
ADNP2ADNP homeobox 2. (1125 aa)
F2Uncharacterized protein; Belongs to the peptidase S1 family. (666 aa)
W5P3B7_SHEEPUncharacterized protein. (408 aa)
HPNHepsin; Belongs to the peptidase S1 family. (418 aa)
W5P3W8_SHEEPRBR-type E3 ubiquitin transferase. (80 aa)
PRKNUbiquitin-like domain-containing protein. (371 aa)
FGFR1OPFGFR1 oncogene partner. (350 aa)
SYT4Synaptotagmin 4. (427 aa)
SUPV3L1Suv3 like RNA helicase. (655 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1028 aa)
SRFSerum response factor. (353 aa)
TRIM32Tripartite motif containing 32. (564 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
CPNE9Copine family member 9. (553 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
YAP1Uncharacterized protein. (397 aa)
CDKN2AIPCDKN2A interacting protein. (578 aa)
SPHK1Sphingosine kinase 1. (459 aa)
EXOSC2Exosome component 2. (295 aa)
CXCL16Uncharacterized protein. (255 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (864 aa)
MEGF8Multiple EGF like domains 8. (2733 aa)
W5PD66_SHEEPAGC-kinase C-terminal domain-containing protein. (403 aa)
RASAL1RAS protein activator like 1. (783 aa)
TEAD1TEA domain transcription factor 1. (436 aa)
CDC42Cell division cycle 42. (237 aa)
SLC25A33Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (302 aa)
HDGFL2HDGF like 2. (630 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1379 aa)
HYAL1Hyaluronidase. (450 aa)
MTPNMyotrophin. (119 aa)
DSCAMDS cell adhesion molecule. (1861 aa)
W5PK14_SHEEPUncharacterized protein. (210 aa)
W5PK84_SHEEPUncharacterized protein; Belongs to the DEAD box helicase family. (516 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
W5PNB9_SHEEPC2 domain-containing protein. (469 aa)
CRYAAAlpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA. (198 aa)
NCBP1Nuclear cap binding protein subunit 1. (792 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (408 aa)
SYT17Synaptotagmin 17. (470 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
ERBB2Receptor protein-tyrosine kinase. (1251 aa)
LIMK1LIM domain kinase 1. (624 aa)
CIB1Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] (217 aa)
ARMC12Armadillo repeat containing 12. (343 aa)
FXNFrataxin. (217 aa)
DBNLDrebrin like. (440 aa)
CDKL5Cyclin dependent kinase like 5. (960 aa)
EGFRReceptor protein-tyrosine kinase. (1155 aa)
CPNE5Copine 5. (599 aa)
KDM2BLysine demethylase 2B. (1308 aa)
NOL12Uncharacterized protein. (214 aa)
SYT3Synaptotagmin 3. (580 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (368 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (215 aa)
EXOSC9Exosome component 9. (440 aa)
PLAAPhospholipase A2 activating protein. (838 aa)
N6AMT1N-6 adenine-specific DNA methyltransferase 1. (229 aa)
SYT1Synaptotagmin 1. (422 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (855 aa)
ADAM17ADAM metallopeptidase domain 17. (825 aa)
EXOSC4Exosome component 4. (247 aa)
UNC13AUnc-13 homolog A. (1727 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (753 aa)
KLHL22Kelch like family member 22. (593 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (424 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1040 aa)
SHTN1Shootin 1. (621 aa)
SFN14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). (248 aa)
W5QAV3_SHEEPC2 domain-containing protein. (261 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
TAF9BTATA-box binding protein associated factor 9b. (257 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (392 aa)
FN1Fibronectin 1. (2478 aa)
MMP14ZnMc domain-containing protein. (586 aa)
UCNUrocortin. (129 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (388 aa)
COMMD5COMM domain containing 5. (224 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (514 aa)
INO80INO80 complex ATPase subunit. (1565 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (973 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1629 aa)
W5QHQ2_SHEEPUncharacterized protein. (479 aa)
ADAM10Uncharacterized protein. (750 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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