(51 nodes) Integral component of mitochondrial inner membrane network (Ovis aries)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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co-expression

protein homology

Your Input:
	W5Q6B1_SHEEP	Uncharacterized protein. (202 aa)
	APOO	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (202 aa)
	W5Q5U2_SHEEP	Peptidase_M41 domain-containing protein. (406 aa)
	SFXN1	Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Transports both D- serine and L-serine. Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out of the mitochondria (By similarity); Belongs t [...] (342 aa)
	MTLN	Uncharacterized protein. (56 aa)
	W5Q4J5_SHEEP	Uncharacterized protein. (264 aa)
	SFXN3	Sidoreflexin. (321 aa)
	W5Q0L7_SHEEP	AAA domain-containing protein. (746 aa)
	LOC101113508	Uncharacterized protein. (305 aa)
	MICOS10	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (78 aa)
	SPG7	AAA domain-containing protein. (787 aa)
	AGK	Acylglycerol kinase. (420 aa)
	COX18	Cytochrome c oxidase assembly factor COX18. (333 aa)
	W5PU91_SHEEP	Peptidase_M41 domain-containing protein. (131 aa)
	MCUR1	Mitochondrial calcium uniporter regulator 1. (234 aa)
	SLC25A3	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (361 aa)
	MPC2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
	SFXN5	Sidoreflexin. (340 aa)
	TIMM17B	Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (172 aa)
	PRR14L	Proline rich 14 like. (2128 aa)
	PISD	Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (408 aa)
	SLC25A19	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (320 aa)
	GHITM	Growth hormone inducible transmembrane protein; Belongs to the BI1 family. (345 aa)
	W5PJK2_SHEEP	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (330 aa)
	W5PDE6_SHEEP	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (161 aa)
	TMEM11	Transmembrane protein 11. (192 aa)
	LOC101118849	Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (209 aa)
	COQ2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (294 aa)
	PET100	PET100 cytochrome c oxidase chaperone. (80 aa)
	APOOL	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (264 aa)
	SFXN2	Sidoreflexin. (325 aa)
	AFG3L2	AFG3 like matrix AAA peptidase subunit 2. (806 aa)
	SFXN4	Sideroflexin 4. (313 aa)
	SLC22A14	Solute carrier family 22 member 14. (626 aa)
	CCDC51	Coiled-coil domain containing 51. (405 aa)
	TIMM17A	Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (172 aa)
	CYTB	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (379 aa)
	MICOS13	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (118 aa)
	MCU	Mitochondrial calcium uniporter. (351 aa)
	CHCHD3	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (232 aa)
	MCUB	Mitochondrial calcium uniporter dominant negative beta subunit. (335 aa)
	COX11	Cytochrome c oxidase copper chaperone COX11. (282 aa)
	MPC1	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (94 aa)
	ETFDH	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (617 aa)
	W5P0F0_SHEEP	Uncharacterized protein. (160 aa)
	COX16	Cytochrome c oxidase assembly factor COX16. (107 aa)
	IMMT	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (813 aa)
	SCO2	SCO cytochrome c oxidase assembly protein 2. (266 aa)
	OXA1L	OXA1L mitochondrial inner membrane protein. (464 aa)
	MPC1L	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (128 aa)
	SMDT1	Single-pass membrane protein with aspartate rich tail 1. (106 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFG3L2	MCU	ENSOARP00000001861	ENSOARP00000007775	AFG3 like matrix AAA peptidase subunit 2.	Mitochondrial calcium uniporter.	0.433
AFG3L2	MCUB	ENSOARP00000001861	ENSOARP00000006479	AFG3 like matrix AAA peptidase subunit 2.	Mitochondrial calcium uniporter dominant negative beta subunit.	0.433
AFG3L2	SMDT1	ENSOARP00000001861	ENSOARP00000020249	AFG3 like matrix AAA peptidase subunit 2.	Single-pass membrane protein with aspartate rich tail 1.	0.635
AFG3L2	SPG7	ENSOARP00000001861	ENSOARP00000015057	AFG3 like matrix AAA peptidase subunit 2.	AAA domain-containing protein.	0.542
AFG3L2	TMEM11	ENSOARP00000001861	ENSOARP00000002678	AFG3 like matrix AAA peptidase subunit 2.	Transmembrane protein 11.	0.488
AFG3L2	W5Q5U2_SHEEP	ENSOARP00000001861	ENSOARP00000018082	AFG3 like matrix AAA peptidase subunit 2.	Peptidase_M41 domain-containing protein.	0.578
AGK	SFXN2	ENSOARP00000014717	ENSOARP00000001910	Acylglycerol kinase.	Sidoreflexin.	0.520
AGK	SFXN4	ENSOARP00000014717	ENSOARP00000001673	Acylglycerol kinase.	Sideroflexin 4.	0.525
AGK	SFXN5	ENSOARP00000014717	ENSOARP00000012495	Acylglycerol kinase.	Sidoreflexin.	0.505
APOO	APOOL	ENSOARP00000018139	ENSOARP00000002182	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.878
APOO	CHCHD3	ENSOARP00000018139	ENSOARP00000007231	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.913
APOO	IMMT	ENSOARP00000018139	ENSOARP00000022180	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.836
APOO	MICOS10	ENSOARP00000018139	ENSOARP00000015537	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.782
APOO	MICOS13	ENSOARP00000018139	ENSOARP00000008111	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.788
APOO	W5PDE6_SHEEP	ENSOARP00000018139	ENSOARP00000008459	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.950
APOOL	APOO	ENSOARP00000002182	ENSOARP00000018139	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.878
APOOL	CHCHD3	ENSOARP00000002182	ENSOARP00000007231	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.953
APOOL	IMMT	ENSOARP00000002182	ENSOARP00000022180	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.903
APOOL	MICOS10	ENSOARP00000002182	ENSOARP00000015537	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.907
APOOL	MICOS13	ENSOARP00000002182	ENSOARP00000008111	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.	0.788