10 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SYK	Tyrosine-protein kinase. (633 aa)
	SNX3	Sorting nexin 3. (162 aa)
	TLR7	TIR domain-containing protein. (1050 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (693 aa)
	RAB5A	Uncharacterized protein. (215 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (645 aa)
	TLR8	TIR domain-containing protein; Belongs to the Toll-like receptor family. (1035 aa)
	TLR9	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (958 aa)
	SYT11	Synaptotagmin 11. (430 aa)
	PLA2G5	Phospholipase A(2). (158 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL1	APPL2	ENSOARP00000015590	ENSOARP00000018492	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.987
APPL1	RAB5A	ENSOARP00000015590	ENSOARP00000016877	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Uncharacterized protein.	0.810
APPL2	APPL1	ENSOARP00000018492	ENSOARP00000015590	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.987
APPL2	RAB5A	ENSOARP00000018492	ENSOARP00000016877	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Uncharacterized protein.	0.812
RAB5A	APPL1	ENSOARP00000016877	ENSOARP00000015590	Uncharacterized protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.810
RAB5A	APPL2	ENSOARP00000016877	ENSOARP00000018492	Uncharacterized protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.812
SYK	TLR7	ENSOARP00000008390	ENSOARP00000012098	Tyrosine-protein kinase.	TIR domain-containing protein.	0.456
SYK	TLR9	ENSOARP00000008390	ENSOARP00000006599	Tyrosine-protein kinase.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.532
TLR7	SYK	ENSOARP00000012098	ENSOARP00000008390	TIR domain-containing protein.	Tyrosine-protein kinase.	0.456
TLR7	TLR8	ENSOARP00000012098	ENSOARP00000019427	TIR domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.934
TLR7	TLR9	ENSOARP00000012098	ENSOARP00000006599	TIR domain-containing protein.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.865
TLR8	TLR7	ENSOARP00000019427	ENSOARP00000012098	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein.	0.934
TLR8	TLR9	ENSOARP00000019427	ENSOARP00000006599	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	0.859
TLR9	SYK	ENSOARP00000006599	ENSOARP00000008390	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	Tyrosine-protein kinase.	0.532
TLR9	TLR7	ENSOARP00000006599	ENSOARP00000012098	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	TIR domain-containing protein.	0.865
TLR9	TLR8	ENSOARP00000006599	ENSOARP00000019427	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity).	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.859