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| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (252 aa) |
| | MAP3K12 | Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (894 aa) |
| | CCNY | Cyclin Y; Belongs to the cyclin family. (308 aa) |
| | STRADB | STE20 related adaptor beta. (418 aa) |
| | BMPR1B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa) |
| | DAZAP2 | DAZ associated protein 2. (168 aa) |
| | ALS2 | Alsin Rho guanine nucleotide exchange factor ALS2. (1657 aa) |
| | HBEGF | Heparin binding EGF like growth factor. (208 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1040 aa) |
| | PRRC1 | Proline rich coiled-coil 1. (445 aa) |
| | MLST8 | MTOR associated protein, LST8 homolog. (291 aa) |
| | PARP16 | Poly [ADP-ribose] polymerase. (324 aa) |
| | MAP2K1 | Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | MT3 | Metallothionein-3; Binds heavy metals. Contains five zinc and one copper atoms per polypeptide chain and only a negligible amount of cadmium (By similarity). (68 aa) |
| | MOB2 | Uncharacterized protein. (47 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (559 aa) |
| | RPLP1 | Ribosomal protein lateral stalk subunit P1; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa) |
| | BMP2 | Bone morphogenetic protein 2. (425 aa) |
| | CCNYL1 | Cyclin Y like 1; Belongs to the cyclin family. (363 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa) |
| | RIPK3 | Receptor interacting serine/threonine kinase 3. (501 aa) |
| | COPS8 | COP9 signalosome subunit 8. (193 aa) |
| | CCNT1 | Cyclin T1; Belongs to the cyclin family. (726 aa) |
| | ERBB4 | Receptor protein-tyrosine kinase. (1103 aa) |
| | CARD10 | Caspase recruitment domain family member 10. (1018 aa) |
| | UCN | Urocortin. (129 aa) |
| | W5QE00_SHEEP | Uncharacterized protein. (67 aa) |
| | SLC11A1 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (571 aa) |
| | CLSPN | Claspin. (1333 aa) |
| | SPDYA | Speedy/RINGO cell cycle regulator family member A. (312 aa) |
| | ALK | Tyrosine-protein kinase receptor. (1012 aa) |
| | CDK5R2 | Cyclin dependent kinase 5 regulatory subunit 2. (276 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (903 aa) |
| | PAK2 | Non-specific serine/threonine protein kinase. (524 aa) |
| | LTK | Leukocyte receptor tyrosine kinase. (863 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (973 aa) |
| | CAB39 | Calcium binding protein 39. (341 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa) |
| | ECT2 | Epithelial cell transforming 2. (917 aa) |
| | GPRC5D | G protein-coupled receptor class C group 5 member D. (345 aa) |
| | GPRC5A | G protein-coupled receptor class C group 5 member A. (359 aa) |
| | FBN1 | Fibrillin 1. (2876 aa) |
| | LOC101115542 | TPX2_importin domain-containing protein. (259 aa) |
| | MNAT1 | MNAT1 component of CDK activating kinase. (285 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | CKS2 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | CAB39L | Calcium binding protein 39 like. (334 aa) |
| | GAS6 | Growth arrest specific 6. (594 aa) |
| | LTF | Uncharacterized protein; Belongs to the transferrin family. (708 aa) |
| | DBF4B | DBF4 zinc finger B. (497 aa) |
| | NTF3 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (266 aa) |
| | DAXX | Death domain associated protein. (762 aa) |
| | RICTOR | RPTOR independent companion of MTOR complex 2. (1708 aa) |
| | PTK2B | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1321 aa) |
| | ADRA2A | Adrenoceptor alpha 2A. (391 aa) |
| | MAP2K2 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa) |
| | W5PMD5_SHEEP | Tyrosine-protein kinase receptor. (336 aa) |
| | W5PME3_SHEEP | Ig-like domain-containing protein. (386 aa) |
| | NTRK3 | LRRNT domain-containing protein. (108 aa) |
| | TGFA | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa) |
| | W5PNG0_SHEEP | Uncharacterized protein. (457 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa) |
| | CCNT2 | Cyclin T2; Belongs to the cyclin family. (768 aa) |
| | LOC101108419 | Uncharacterized protein. (295 aa) |
| | PRLR | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (581 aa) |
| | GHRL | Uncharacterized protein. (134 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa) |
| | AXIN1 | Axin 1. (865 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (778 aa) |
| | MOB1B | MOB kinase activator 1B. (223 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa) |
| | MOB1A | MOB kinase activator 1A. (230 aa) |
| | WNK1 | WNK lysine deficient protein kinase 1. (2337 aa) |
| | GPRC5B | G protein-coupled receptor class C group 5 member B. (396 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | RNASE4 | Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (147 aa) |
| | IQGAP1 | IQ motif containing GTPase activating protein 1. (1691 aa) |
| | DBF4 | DBF4 zinc finger. (677 aa) |
| | STRADA | Protein kinase domain-containing protein. (431 aa) |
| | ALKAL1 | Uncharacterized protein. (67 aa) |
| | CDKN1A | Uncharacterized protein. (163 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1155 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa) |
| | DAB2IP | DAB2 interacting protein. (1100 aa) |
| | MOB3A | MOB kinase activator 3A. (217 aa) |
| | MOB3B | MOB kinase activator 3B. (216 aa) |
| | INCENP | Inner centromere protein. (866 aa) |
| | TGFBR2 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa) |
| | AFAP1L2 | Actin filament associated protein 1 like 2. (868 aa) |
| | OSBPL8 | Oxysterol-binding protein; Belongs to the OSBP family. (848 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (135 aa) |
| | EPGN | Epithelial mitogen. (152 aa) |
| | EREG | Epiregulin. (169 aa) |
| | FAM20A | FAM20A golgi associated secretory pathway pseudokinase. (506 aa) |
| | CAMKK2 | Calcium/calmodulin dependent protein kinase kinase 2. (570 aa) |
| | ITGB1BP1 | Integrin subunit beta 1 binding protein 1. (204 aa) |
| | AREG | Amphiregulin. (247 aa) |
| | ANGPT1 | Angiopoietin 1. (485 aa) |
| | BTC | Betacellulin. (213 aa) |
| | BORA | BORA aurora kinase A activator. (620 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | PIBF1 | Progesterone immunomodulatory binding factor 1. (757 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa) |
| | W5Q340_SHEEP | Uncharacterized protein. (115 aa) |
| | TCL1A | Uncharacterized protein. (119 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. (194 aa) |
| | ABI1 | Abl interactor 1. (481 aa) |
| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1642 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1134 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | W5Q448_SHEEP | Ras-associating domain-containing protein. (707 aa) |
| | ABL1 | Tyrosine-protein kinase. (1020 aa) |
| | PPP2R3C | Protein phosphatase 2 regulatory subunit B''gamma. (453 aa) |
| | RGCC | Uncharacterized protein. (63 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (293 aa) |
| | W5PAS2_SHEEP | Prohibitin. (253 aa) |
| | PDGFC | Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (307 aa) |
| | FAM20C | FAM20C golgi associated secretory pathway kinase. (466 aa) |
| | PHB | Prohibitin. (272 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (652 aa) |
| | EMP2 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa) |
| | MALT1 | MALT1 paracaspase. (764 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (905 aa) |
| | PHB2 | Prohibitin. (270 aa) |
| | W5P4C4_SHEEP | CLLAC domain-containing protein. (167 aa) |
| | W5P4B9_SHEEP | CLLAC domain-containing protein. (262 aa) |
| | W5P484_SHEEP | Uncharacterized protein. (256 aa) |
| | W5P477_SHEEP | CLLAC domain-containing protein. (152 aa) |
| | TOM1L1 | Target of myb1 like 1 membrane trafficking protein; Belongs to the TOM1 family. (479 aa) |
| | PRKAG2 | Protein kinase AMP-activated non-catalytic subunit gamma 2. (324 aa) |
| | W5P2A1_SHEEP | Uncharacterized protein; Belongs to the eukaryotic ribosomal protein P1/P2 family. (114 aa) |
| | TRAF4 | TNF receptor-associated factor. (454 aa) |
| | CDK5R1 | Cyclin dependent kinase 5 regulatory subunit 1. (300 aa) |
| | W5P0G0_SHEEP | Uncharacterized protein. (97 aa) |
| | IGF2 | Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (263 aa) |
| | WNK4 | WNK lysine deficient protein kinase 4. (1139 aa) |
| | MTCP1 | Mature T cell proliferation 1. (107 aa) |
| | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor. (225 aa) |
| | W5NZG1_SHEEP | Uncharacterized protein. (417 aa) |
| | CKS1B | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | MAS1 | MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa) |
| | MOB3C | MOB kinase activator 3C. (230 aa) |
| | DDX3X | DEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (661 aa) |
| | CCDC88A | Coiled-coil domain containing 88A. (2026 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (204 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1481 aa) |
| | FGF1 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (155 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa) |
| | TPX2 | TPX2 microtubule nucleation factor. (747 aa) |
| | CHI3L1 | Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (453 aa) |
| | TRAF2-2 | MATH domain-containing protein. (215 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (534 aa) |
| | CCNK | Cyclin K; Belongs to the cyclin family. (431 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1388 aa) |
| | W5NQ99_SHEEP | Uncharacterized protein; Belongs to the eukaryotic ribosomal protein P1/P2 family. (115 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | NRG1 | Neuregulin 1. (664 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
