58 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SHH	Uncharacterized protein. (232 aa)
	NDFIP1	Nedd4 family interacting protein 1. (222 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa)
	IDO1	Indoleamine-pyrrole 2,3 dioxygenase. (410 aa)
	CLEC4G	C-type lectin domain family 4 member G. (292 aa)
	CCND3	Uncharacterized protein; Belongs to the cyclin family. (401 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1430 aa)
	PSMB10	Proteasome subunit beta. (273 aa)
	TSPAN32	Uncharacterized protein. (227 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (461 aa)
	CARD11	Caspase recruitment domain family member 11. (1153 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (595 aa)
	MSN	Moesin. (665 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (905 aa)
	MALT1	MALT1 paracaspase. (764 aa)
	TNFSF13B	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (288 aa)
	SH2D2A	SH2 domain containing 2A. (411 aa)
	CRIP3	Cysteine rich protein 3. (204 aa)
	ABL1	Tyrosine-protein kinase. (1020 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	NCSTN	Nicastrin. (720 aa)
	CD3E	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] (201 aa)
	IL23A	Uncharacterized protein. (190 aa)
	ARMC5	Armadillo repeat containing 5. (776 aa)
	FYN	Tyrosine-protein kinase. (537 aa)
	ITCH	E3 ubiquitin-protein ligase. (845 aa)
	FOXP3	Fork-head domain-containing protein. (474 aa)
	EBI3	Epstein-Barr virus induced 3. (235 aa)
	PRDX2	Peroxiredoxin 2. (198 aa)
	GPAM	Glycerol-3-phosphate acyltransferase, mitochondrial. (893 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1251 aa)
	IL15	Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (161 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1140 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (2101 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	TNFSF18	TNF superfamily member 18. (194 aa)
	EFNB1	Ephrin B1; Belongs to the ephrin family. (348 aa)
	SASH3	SAM and SH3 domain containing 3. (381 aa)
	ELF4	E74 like ETS transcription factor 4. (662 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (382 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1235 aa)
	SELENOK	Selenoprotein K. (92 aa)
	EPHB6	EPH receptor B6. (931 aa)
	FKBP1B	Peptidylprolyl isomerase. (108 aa)
	CD28	IGv domain-containing protein. (265 aa)
	FKBP1A	Peptidylprolyl isomerase. (103 aa)
	CBLB	Cbl proto-oncogene B. (983 aa)
	LMBR1L	Limb development membrane protein 1 like; Belongs to the LIMR family. (507 aa)
	STAT5B	Signal transducer and activator of transcription. (791 aa)
	SLC11A1	Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (571 aa)
	PELI1	E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (419 aa)
	RASGRP1	RAS guanyl releasing protein 1. (797 aa)
	CTPS1	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (610 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
	HES1	Hes family bHLH transcription factor 1. (248 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CBLB	ENSOARP00000007959	ENSOARP00000020168	Tyrosine-protein kinase.	Cbl proto-oncogene B.	0.541
ABL1	TP53	ENSOARP00000007959	ENSOARP00000016707	Tyrosine-protein kinase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.603
CARD11	FYN	ENSOARP00000004667	ENSOARP00000010438	Caspase recruitment domain family member 11.	Tyrosine-protein kinase.	0.551
CARD11	MALT1	ENSOARP00000004667	ENSOARP00000005942	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.965
CARD11	PRKCQ	ENSOARP00000004667	ENSOARP00000014194	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.951
CARD11	PTPN6	ENSOARP00000004667	ENSOARP00000005396	Caspase recruitment domain family member 11.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.466
CARD11	RIPK2	ENSOARP00000004667	ENSOARP00000012001	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.553
CBLB	ABL1	ENSOARP00000020168	ENSOARP00000007959	Cbl proto-oncogene B.	Tyrosine-protein kinase.	0.541
CBLB	ERBB2	ENSOARP00000020168	ENSOARP00000012725	Cbl proto-oncogene B.	Receptor protein-tyrosine kinase.	0.752
CBLB	FYN	ENSOARP00000020168	ENSOARP00000010438	Cbl proto-oncogene B.	Tyrosine-protein kinase.	0.954
CBLB	PTPN6	ENSOARP00000020168	ENSOARP00000005396	Cbl proto-oncogene B.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.460
CBLB	RIPK2	ENSOARP00000020168	ENSOARP00000012001	Cbl proto-oncogene B.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.409
CCND3	FYN	ENSOARP00000003104	ENSOARP00000010438	Uncharacterized protein; Belongs to the cyclin family.	Tyrosine-protein kinase.	0.419
CCND3	TP53	ENSOARP00000003104	ENSOARP00000016707	Uncharacterized protein; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.589
CD28	PRKCQ	ENSOARP00000019614	ENSOARP00000014194	IGv domain-containing protein.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.936
CD28	PTPRC	ENSOARP00000019614	ENSOARP00000016883	IGv domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.456
CD3E	FOXP3	ENSOARP00000009648	ENSOARP00000011020	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Fork-head domain-containing protein.	0.726
CD3E	PRKCQ	ENSOARP00000009648	ENSOARP00000014194	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.410
CD3E	PTPN6	ENSOARP00000009648	ENSOARP00000005396	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.709
CD3E	PTPRC	ENSOARP00000009648	ENSOARP00000016883	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	Protein tyrosine phosphatase receptor type C.	0.726