7 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPO11	SPO11 initiator of meiotic double stranded breaks. (395 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
	MEI4	Meiotic double-stranded break formation protein 4. (395 aa)
	C21H11orf80	Uncharacterized protein. (421 aa)
	CCDC36	Coiled-coil domain containing 36. (599 aa)
	ANKRD31	ANK_REP_REGION domain-containing protein. (1276 aa)
	HORMAD1	HORMA domain containing 1. (393 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD31	HORMAD1	ENSOARP00000017933	ENSOARP00000022408	ANK_REP_REGION domain-containing protein.	HORMA domain containing 1.	0.515
ANKRD31	MEI4	ENSOARP00000017933	ENSOARP00000007256	ANK_REP_REGION domain-containing protein.	Meiotic double-stranded break formation protein 4.	0.536
ANKRD31	SPO11	ENSOARP00000017933	ENSOARP00000019324	ANK_REP_REGION domain-containing protein.	SPO11 initiator of meiotic double stranded breaks.	0.527
C21H11orf80	SPO11	ENSOARP00000008940	ENSOARP00000019324	Uncharacterized protein.	SPO11 initiator of meiotic double stranded breaks.	0.510
CCDC36	HORMAD1	ENSOARP00000015320	ENSOARP00000022408	Coiled-coil domain containing 36.	HORMA domain containing 1.	0.780
HORMAD1	ANKRD31	ENSOARP00000022408	ENSOARP00000017933	HORMA domain containing 1.	ANK_REP_REGION domain-containing protein.	0.515
HORMAD1	CCDC36	ENSOARP00000022408	ENSOARP00000015320	HORMA domain containing 1.	Coiled-coil domain containing 36.	0.780
HORMAD1	MEI4	ENSOARP00000022408	ENSOARP00000007256	HORMA domain containing 1.	Meiotic double-stranded break formation protein 4.	0.477
HORMAD1	SPO11	ENSOARP00000022408	ENSOARP00000019324	HORMA domain containing 1.	SPO11 initiator of meiotic double stranded breaks.	0.944
MEI4	ANKRD31	ENSOARP00000007256	ENSOARP00000017933	Meiotic double-stranded break formation protein 4.	ANK_REP_REGION domain-containing protein.	0.536
MEI4	HORMAD1	ENSOARP00000007256	ENSOARP00000022408	Meiotic double-stranded break formation protein 4.	HORMA domain containing 1.	0.477
MEI4	SPO11	ENSOARP00000007256	ENSOARP00000019324	Meiotic double-stranded break formation protein 4.	SPO11 initiator of meiotic double stranded breaks.	0.483
MRE11	SPO11	ENSOARP00000002235	ENSOARP00000019324	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	SPO11 initiator of meiotic double stranded breaks.	0.708
SPO11	ANKRD31	ENSOARP00000019324	ENSOARP00000017933	SPO11 initiator of meiotic double stranded breaks.	ANK_REP_REGION domain-containing protein.	0.527
SPO11	C21H11orf80	ENSOARP00000019324	ENSOARP00000008940	SPO11 initiator of meiotic double stranded breaks.	Uncharacterized protein.	0.510
SPO11	HORMAD1	ENSOARP00000019324	ENSOARP00000022408	SPO11 initiator of meiotic double stranded breaks.	HORMA domain containing 1.	0.944
SPO11	MEI4	ENSOARP00000019324	ENSOARP00000007256	SPO11 initiator of meiotic double stranded breaks.	Meiotic double-stranded break formation protein 4.	0.483
SPO11	MRE11	ENSOARP00000019324	ENSOARP00000002235	SPO11 initiator of meiotic double stranded breaks.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.708