(45 nodes) Receptor clustering network (Ovis aries)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIGR	Polymeric immunoglobulin receptor. (782 aa)
	DLG1	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
	GLRB	Glycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (498 aa)
	ITGAL	VWFA domain-containing protein; Belongs to the integrin alpha chain family. (1164 aa)
	ERBIN	Erbb2 interacting protein. (1457 aa)
	FLNA	Filamin A. (2633 aa)
	DLG2	Discs large MAGUK scaffold protein 2. (905 aa)
	W5P4Z9_SHEEP	MAGUK_N_PEST domain-containing protein. (61 aa)
	LRP4	LDL receptor related protein 4. (1911 aa)
	SYNJ2BP	PDZ domain-containing protein. (145 aa)
	DVL1	Dishevelled segment polarity protein 1. (693 aa)
	FNTA	Uncharacterized protein. (329 aa)
	CDK5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	SSNA1	SS nuclear autoantigen 1. (101 aa)
	W5NVE0_SHEEP	Uncharacterized protein. (521 aa)
	SHISA7	Shisa family member 7. (497 aa)
	RELN	Uncharacterized protein. (3578 aa)
	MELTF	Melanotransferrin; Belongs to the transferrin family. (739 aa)
	LRRTM4	Leucine rich repeat transmembrane neuronal 4. (518 aa)
	SHANK3	SH3 and multiple ankyrin repeat domains 3. (1446 aa)
	RER1	Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (196 aa)
	CHRDL1	Chordin like 1. (455 aa)
	MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2. (972 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1034 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	NLGN1	COesterase domain-containing protein. (616 aa)
	GPHN	Gephyrin. (791 aa)
	W5QJ76_SHEEP	PDZ domain-containing protein. (124 aa)
	WDR19	WD repeat domain 19. (1342 aa)
	DLG4	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (810 aa)
	SYNGAP1	Synaptic Ras GTPase activating protein 1. (1326 aa)
	PTN	Pleiotrophin. (168 aa)
	ITGB2	Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (750 aa)
	APOE	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
	AGRN	Uncharacterized protein. (2043 aa)
	LRRC1	Leucine rich repeat containing 1. (443 aa)
	ITGB7	Integrin beta; Belongs to the integrin beta chain family. (798 aa)
	SCRIB	Scribble planar cell polarity protein. (1499 aa)
	DLG3	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (847 aa)
	COLQ	Collagen like tail subunit of asymmetric acetylcholinesterase. (449 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (204 aa)
	PICK1	Protein interacting with PRKCA 1. (441 aa)
	SLITRK3	SLIT and NTRK like family member 3. (980 aa)
	NLGN2	Neuroligin 2. (718 aa)
	LHFPL4	LHFPL tetraspan subfamily member 4. (228 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGRN	APOE	ENSOARP00000007547	ENSOARP00000010129	Uncharacterized protein.	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	0.500
AGRN	COLQ	ENSOARP00000007547	ENSOARP00000016230	Uncharacterized protein.	Collagen like tail subunit of asymmetric acetylcholinesterase.	0.483
AGRN	LRP4	ENSOARP00000007547	ENSOARP00000005046	Uncharacterized protein.	LDL receptor related protein 4.	0.979
APOE	AGRN	ENSOARP00000010129	ENSOARP00000007547	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Uncharacterized protein.	0.500
APOE	LRP4	ENSOARP00000010129	ENSOARP00000005046	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	LDL receptor related protein 4.	0.400
APOE	W5NVE0_SHEEP	ENSOARP00000010129	ENSOARP00000002136	Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]	Uncharacterized protein.	0.500
CDK5	LRP4	ENSOARP00000002796	ENSOARP00000005046	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily.	LDL receptor related protein 4.	0.416
COLQ	AGRN	ENSOARP00000016230	ENSOARP00000007547	Collagen like tail subunit of asymmetric acetylcholinesterase.	Uncharacterized protein.	0.483
DLG1	DLG2	ENSOARP00000021884	ENSOARP00000005556	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 2.	0.901
DLG1	DLG3	ENSOARP00000021884	ENSOARP00000016890	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	0.862
DLG1	DLG4	ENSOARP00000021884	ENSOARP00000011160	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.950
DLG1	ERBIN	ENSOARP00000021884	ENSOARP00000006453	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	Erbb2 interacting protein.	0.435
DLG1	SHANK3	ENSOARP00000021884	ENSOARP00000021495	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	SH3 and multiple ankyrin repeat domains 3.	0.582
DLG2	DLG1	ENSOARP00000005556	ENSOARP00000021884	Discs large MAGUK scaffold protein 2.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.901
DLG2	DLG3	ENSOARP00000005556	ENSOARP00000016890	Discs large MAGUK scaffold protein 2.	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	0.863
DLG2	DLG4	ENSOARP00000005556	ENSOARP00000011160	Discs large MAGUK scaffold protein 2.	Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.	0.911
DLG2	ERBIN	ENSOARP00000005556	ENSOARP00000006453	Discs large MAGUK scaffold protein 2.	Erbb2 interacting protein.	0.430
DLG2	SHANK3	ENSOARP00000005556	ENSOARP00000021495	Discs large MAGUK scaffold protein 2.	SH3 and multiple ankyrin repeat domains 3.	0.594
DLG3	DLG1	ENSOARP00000016890	ENSOARP00000021884	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.	0.862
DLG3	DLG2	ENSOARP00000016890	ENSOARP00000005556	Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family.	Discs large MAGUK scaffold protein 2.	0.863