STRINGSTRING
FER FER W5NPL3_SHEEP W5NPL3_SHEEP ITGAL ITGAL W5PAC7_SHEEP W5PAC7_SHEEP CD99 CD99 W5PEH4_SHEEP W5PEH4_SHEEP ITGA1 ITGA1 TNF TNF GCNT1 GCNT1 JAML JAML MADCAM1 MADCAM1 ROCK1 ROCK1 F11R F11R PRTN3 PRTN3 EXT1 EXT1 SELP SELP SELL SELL SELE SELE ADD2 ADD2 CRK CRK GOLPH3 GOLPH3 W5PVN6_SHEEP W5PVN6_SHEEP CX3CR1 CX3CR1 PECAM1 PECAM1 JAM2 JAM2 CRKL CRKL ITGB7 ITGB7 ITGA4 ITGA4 TRIM55 TRIM55
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (825 aa)
W5NPL3_SHEEPSCY domain-containing protein. (433 aa)
ITGALVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1164 aa)
W5PAC7_SHEEPUncharacterized protein. (456 aa)
CD99CD99 molecule (Xg blood group). (189 aa)
W5PEH4_SHEEPUncharacterized protein. (372 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1166 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
JAMLJunction adhesion molecule like. (384 aa)
MADCAM1Adhes-Ig_like domain-containing protein. (378 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1372 aa)
F11RF11 receptor. (298 aa)
PRTN3Proteinase 3; Belongs to the peptidase S1 family. (253 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (748 aa)
SELPP-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. (769 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (383 aa)
SELEUncharacterized protein. (484 aa)
ADD2Adducin 2. (721 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
W5PVN6_SHEEPProtein kinase domain-containing protein. (210 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (812 aa)
JAM2Junctional adhesion molecule 2. (299 aa)
CRKLCRK like proto-oncogene, adaptor protein. (305 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1034 aa)
TRIM55Tripartite motif containing 55. (546 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.