71 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NANOS1	Nanos-type domain-containing protein; Belongs to the nanos family. (125 aa)
	CDC25B	Cell division cycle 25B. (574 aa)
	PLD6	Phospholipase D family member 6. (220 aa)
	PTPN9	Protein tyrosine phosphatase non-receptor type 9. (627 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (585 aa)
	DDX20	DEAD-box helicase 20. (827 aa)
	TDRD15	Tudor domain containing 15. (1948 aa)
	REC8	REC8 meiotic recombination protein. (592 aa)
	PAQR5	Progestin and adipoQ receptor family member 5. (330 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (395 aa)
	SEBOX	SEBOX homeobox. (207 aa)
	SRC	Tyrosine-protein kinase. (541 aa)
	H3F3A	Histone H3.3. (136 aa)
	TDRD5	Tudor domain containing 5. (1039 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (558 aa)
	ZFX	Uncharacterized protein. (800 aa)
	PGRMC1	Uncharacterized protein. (87 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (409 aa)
	ZGLP1	Zinc finger GATA like protein 1. (270 aa)
	C14orf39	Chromosome 14 open reading frame 39. (584 aa)
	TDRKH	Tudor and KH domain containing. (560 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (862 aa)
	CCDC36	Coiled-coil domain containing 36. (599 aa)
	TDRD1	Uncharacterized protein. (1197 aa)
	EDN1	Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (215 aa)
	ZP3	ZP domain-containing protein. (408 aa)
	W5PWR4_SHEEP	Protein kinase domain-containing protein. (247 aa)
	GDF9	Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
	DMRT1	Doublesex and mab-3 related transcription factor 1. (332 aa)
	W5PTV0_SHEEP	Tudor domain-containing protein. (116 aa)
	CCDC155	Coiled-coil domain containing 155. (564 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa)
	MTHFSD	Methenyltetrahydrofolate synthetase domain containing. (380 aa)
	NANOS2	Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
	W5PNU4_SHEEP	Histone H3; Belongs to the histone H3 family. (136 aa)
	TDRD7	Tudor domain containing 7. (1098 aa)
	BRCA2	BRCA2 DNA repair associated. (3427 aa)
	TDRD6	Tudor domain containing 6. (2015 aa)
	FOXO3	Fork-head domain-containing protein. (473 aa)
	W5PLC4_SHEEP	BHLH domain-containing protein. (428 aa)
	PIWIL2	Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (973 aa)
	BHMG1	Basic helix-loop-helix and HMG-box containing 1. (624 aa)
	ERCC1	ERCC excision repair 1, endonuclease non-catalytic subunit. (299 aa)
	PTN	Pleiotrophin. (168 aa)
	LOC101108931	Histone H3; Belongs to the histone H3 family. (136 aa)
	TNFAIP6	TNF alpha induced protein 6. (280 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (963 aa)
	YTHDC1	YTH domain containing 1. (728 aa)
	MARF1	Meiosis regulator and mRNA stability factor 1. (1743 aa)
	STRA8	Stimulated by retinoic acid 8. (366 aa)
	WASHC5	WASH complex subunit 5. (1160 aa)
	EDNRA	Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
	NANOS3	Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (180 aa)
	MEI4	Meiotic double-stranded break formation protein 4. (395 aa)
	W5P8T2_SHEEP	Uncharacterized protein. (224 aa)
	W5P8A8_SHEEP	Uncharacterized protein. (81 aa)
	PAQR6	Uncharacterized protein. (424 aa)
	W5P5A8_SHEEP	Histone domain-containing protein. (136 aa)
	W5P4S1_SHEEP	Uncharacterized protein. (337 aa)
	FBXO5	F-box protein 5. (413 aa)
	ZNF830	Zinc finger protein 830. (373 aa)
	LOC101115386	Histone domain-containing protein. (136 aa)
	AURKC	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (308 aa)
	GPR149	G protein-coupled receptor 149. (742 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1268 aa)
	CTNNB1	Catenin beta 1. (782 aa)
	TDRD10	Tudor domain containing 10. (351 aa)
	PTX3	Pentraxin 3. (380 aa)
	HORMAD1	HORMA domain containing 1. (393 aa)
	PDE3A	Phosphodiesterase. (829 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BRCA2	ENSOARP00000012764	ENSOARP00000011988	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.958
ATM	CTNNB1	ENSOARP00000012764	ENSOARP00000003072	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Catenin beta 1.	0.511
ATM	DMC1	ENSOARP00000012764	ENSOARP00000016725	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.790
ATM	ERCC1	ENSOARP00000012764	ENSOARP00000010674	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ERCC excision repair 1, endonuclease non-catalytic subunit.	0.789
ATM	H3F3A	ENSOARP00000012764	ENSOARP00000019160	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3.3.	0.533
ATM	HORMAD1	ENSOARP00000012764	ENSOARP00000022408	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	HORMA domain containing 1.	0.477
ATM	LOC101108931	ENSOARP00000012764	ENSOARP00000010254	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.708
ATM	LOC101115386	ENSOARP00000012764	ENSOARP00000004168	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone domain-containing protein.	0.705
ATM	SPO11	ENSOARP00000012764	ENSOARP00000019324	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SPO11 initiator of meiotic double stranded breaks.	0.785
ATM	SRC	ENSOARP00000012764	ENSOARP00000019257	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.466
ATM	TRIP13	ENSOARP00000012764	ENSOARP00000017264	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.506
ATM	W5P5A8_SHEEP	ENSOARP00000012764	ENSOARP00000005611	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone domain-containing protein.	0.759
ATM	W5PNU4_SHEEP	ENSOARP00000012764	ENSOARP00000012120	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.706
AURKC	FBXO5	ENSOARP00000003686	ENSOARP00000004240	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	F-box protein 5.	0.517
AURKC	H3F3A	ENSOARP00000003686	ENSOARP00000019160	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Histone H3.3.	0.422
AURKC	LOC101108931	ENSOARP00000003686	ENSOARP00000010254	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Histone H3; Belongs to the histone H3 family.	0.422
AURKC	TRIP13	ENSOARP00000003686	ENSOARP00000017264	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.426
BHMG1	W5P4S1_SHEEP	ENSOARP00000010967	ENSOARP00000005424	Basic helix-loop-helix and HMG-box containing 1.	Uncharacterized protein.	0.412
BMPR1B	CTNNB1	ENSOARP00000018416	ENSOARP00000003072	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Catenin beta 1.	0.437
BMPR1B	GDF9	ENSOARP00000018416	ENSOARP00000014175	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	0.976