STRINGSTRING
DHCR7 DHCR7 FMO3 FMO3 LOC101104591 LOC101104591 FMO2 FMO2 CRYZ CRYZ TM7SF2 TM7SF2 FMO1 FMO1 GLYR1 GLYR1 NOS1 NOS1 G6PD G6PD ME3 ME3 GAPDHS GAPDHS FMO4 FMO4 HSD11B1 HSD11B1 PGD PGD GAPDH GAPDH H6PD H6PD HIBADH HIBADH QDPR QDPR NOS3 NOS3 GSR GSR DECR1 DECR1 W5PLR0_SHEEP W5PLR0_SHEEP W5PNL2_SHEEP W5PNL2_SHEEP GRHPR GRHPR W5PQ29_SHEEP W5PQ29_SHEEP FDXR FDXR W5NWX9_SHEEP W5NWX9_SHEEP GMDS GMDS KCNAB1 KCNAB1 DUS2 DUS2 CAT CAT W5QFD8_SHEEP W5QFD8_SHEEP FMO5 FMO5 POR POR CBR3 CBR3 ASPDH ASPDH MTRR MTRR CRYM CRYM DHFR DHFR CBR4 CBR4 HMGCR HMGCR NOS2 NOS2 LBR LBR DPYD DPYD TP53I3 TP53I3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DHCR77-dehydrocholesterol reductase. (452 aa)
FMO3Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
LOC101104591Dimethylaniline monooxygenase [N-oxide-forming]. (534 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
CRYZCrystallin zeta. (330 aa)
TM7SF2Transmembrane 7 superfamily member 2. (420 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
GLYR1Glyoxylate reductase 1 homolog. (576 aa)
NOS1Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
ME3Malic enzyme. (604 aa)
GAPDHSGlyceraldehyde-3-phosphate dehydrogenase, spermatogenic; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (370 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (547 aa)
HSD11B1Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of corticosterone to 11- dehydrocorticosterone. (292 aa)
PGD6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (542 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (767 aa)
HIBADHUncharacterized protein. (330 aa)
QDPRQuinoid dihydropteridine reductase. (224 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)
GSRUncharacterized protein. (420 aa)
DECR12,4-dienoyl-CoA reductase 1. (392 aa)
W5PLR0_SHEEPUncharacterized protein. (506 aa)
W5PNL2_SHEEPUncharacterized protein. (284 aa)
GRHPRGlyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
W5PQ29_SHEEPDimethylaniline monooxygenase [N-oxide-forming]. (533 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (489 aa)
W5NWX9_SHEEPFlavodoxin-like domain-containing protein. (213 aa)
GMDSGDP-mannose 4,6-dehydratase. (338 aa)
KCNAB1Potassium voltage-gated channel subfamily A member regulatory beta subunit 1. (401 aa)
DUS2Dihydrouridine synthase 2. (493 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
W5QFD8_SHEEPPyr_redox_2 domain-containing protein. (352 aa)
FMO5Dimethylaniline monooxygenase [N-oxide-forming]. (536 aa)
PORCytochrome p450 oxidoreductase. (649 aa)
CBR3Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa)
ASPDHAspartate dehydrogenase domain containing. (301 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (723 aa)
CRYMCrystallin mu. (314 aa)
DHFRDHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
CBR4Carbonyl reductase 4. (241 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
LBRLamin B receptor. (622 aa)
DPYDDihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa)
TP53I3Tumor protein p53 inducible protein 3. (332 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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