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| | C5AR2 | Complement component 5a receptor 2. (339 aa) |
| | C5AR1 | Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | ODAM | Odontogenic, ameloblast associated. (279 aa) |
| | TGFBR1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa) |
| | XDH | Xanthine dehydrogenase. (1329 aa) |
| | W5PMM1_SHEEP | Uncharacterized protein. (249 aa) |
| | TBC1D31 | TBC1 domain family member 31. (1063 aa) |
| | W5PM90_SHEEP | Uncharacterized protein. (265 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (868 aa) |
| | SIRT6 | Sirtuin 6. (361 aa) |
| | JAG1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1198 aa) |
| | RUNX2 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (475 aa) |
| | EGR3 | Early growth response 3. (351 aa) |
| | TRIM24 | Tripartite motif containing 24. (934 aa) |
| | SULF2 | Sulfatase 2. (727 aa) |
| | NKX3-1 | NK3 homeobox 1. (246 aa) |
| | NKX2-6 | NK2 homeobox 6. (302 aa) |
| | VASH2 | Vasohibin 2. (355 aa) |
| | PTN | Pleiotrophin. (168 aa) |
| | W5PJ00_SHEEP | Homeobox domain-containing protein. (406 aa) |
| | HYAL1 | Hyaluronidase. (450 aa) |
| | CCL2 | C-C motif chemokine. (115 aa) |
| | CDH13 | Cadherin 13. (608 aa) |
| | CCL11 | C-C motif chemokine. (101 aa) |
| | B4GALT1 | Uncharacterized protein. (402 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa) |
| | LOC101123184 | tRNA-binding domain-containing protein. (322 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | MAGED1 | MAGE family member D1. (801 aa) |
| | LRG1 | Leucine rich alpha-2-glycoprotein 1. (353 aa) |
| | CDC73 | Cell division cycle 73. (488 aa) |
| | MYDGF | Myeloid derived growth factor. (129 aa) |
| | W5PH60_SHEEP | tRNA-binding domain-containing protein. (323 aa) |
| | SPARC | Kazal-like domain-containing protein. (462 aa) |
| | MTSS1 | MTSS I-BAR domain containing 1. (722 aa) |
| | W5PFK3_SHEEP | tRNA-binding domain-containing protein. (264 aa) |
| | PTCH1 | Patched 1. (1450 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa) |
| | UHRF1 | Ubiquitin like with PHD and ring finger domains 1. (755 aa) |
| | TACSTD2 | Tumor associated calcium signal transducer 2. (319 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (228 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa) |
| | RB1 | RB transcriptional corepressor 1. (939 aa) |
| | GRN | Granulin precursor. (588 aa) |
| | CDC42 | Cell division cycle 42. (237 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (423 aa) |
| | FGFBP1 | Fibroblast growth factor binding protein 1. (234 aa) |
| | W5PD66_SHEEP | AGC-kinase C-terminal domain-containing protein. (403 aa) |
| | PIK3CD | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1106 aa) |
| | A4GNT | Alpha-1,4-N-acetylglucosaminyltransferase. (341 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | MTA3 | Uncharacterized protein. (551 aa) |
| | W5PBE5_SHEEP | ATP-synt_ab_C domain-containing protein. (106 aa) |
| | AQP11 | Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa) |
| | SHH | Uncharacterized protein. (232 aa) |
| | PLXNB3 | Plexin B3. (1813 aa) |
| | VEGFC | Vascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (370 aa) |
| | CNMD | Chondromodulin. (362 aa) |
| | GLI1 | GLI family zinc finger 1. (1107 aa) |
| | YAP1 | Uncharacterized protein. (397 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa) |
| | SERPINB5 | Serpin family B member 5; Belongs to the serpin family. (387 aa) |
| | BMP5 | Bone morphogenetic protein 5. (454 aa) |
| | W5P8P1_SHEEP | Uncharacterized protein. (478 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa) |
| | DEAF1 | DEAF1 transcription factor. (509 aa) |
| | BAD | BCL2 associated agonist of cell death. (179 aa) |
| | CD109 | CD109 molecule. (1443 aa) |
| | W5P8A8_SHEEP | Uncharacterized protein. (81 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (327 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa) |
| | ZFP36 | mRNA decay activator protein ZFP36; Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'- untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting compo [...] (324 aa) |
| | NODAL | Nodal growth differentiation factor. (346 aa) |
| | IQGAP3 | IQ motif containing GTPase activating protein 3. (1633 aa) |
| | NGFR | Nerve growth factor receptor. (436 aa) |
| | IRS2 | IRS-type PTB domain-containing protein. (137 aa) |
| | BIRC5 | Baculoviral IAP repeat containing 5. (142 aa) |
| | AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (996 aa) |
| | FGFR2 | Fibroblast growth factor receptor. (841 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (345 aa) |
| | VEGFB | Vascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (182 aa) |
| | DLG2 | Discs large MAGUK scaffold protein 2. (905 aa) |
| | VHL | Uncharacterized protein. (100 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (833 aa) |
| | STXBP4 | Syntaxin binding protein 4. (559 aa) |
| | PHB2 | Prohibitin. (270 aa) |
| | MMP12 | Matrix metallopeptidase 12. (470 aa) |
| | SIRT1 | Sirtuin 1. (610 aa) |
| | STK4 | Serine/threonine kinase 4. (488 aa) |
| | HPN | Hepsin; Belongs to the peptidase S1 family. (418 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa) |
| | DLX5 | Distal-less homeobox 5. (290 aa) |
| | SYNJ2BP | PDZ domain-containing protein. (145 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (698 aa) |
| | ZNF703 | Uncharacterized protein. (112 aa) |
| | VIP | Vasoactive intestinal peptide. (170 aa) |
| | KDF1 | Keratinocyte differentiation factor 1. (345 aa) |
| | NOTCH1 | Notch receptor 1. (2008 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa) |
| | EGFL7 | EGF like domain multiple 7. (279 aa) |
| | ZNF304 | Zinc finger protein 304. (690 aa) |
| | CDH3 | Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (776 aa) |
| | ESRP2 | Epithelial splicing regulatory protein 2. (715 aa) |
| | IFT52 | Intraflagellar transport 52. (434 aa) |
| | SULF1 | Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) |
| | SRSF6 | Serine and arginine rich splicing factor 6. (343 aa) |
| | STK3 | Serine/threonine kinase 3. (494 aa) |
| | W5NYJ5_SHEEP | Cu2_monoox_C domain-containing protein. (278 aa) |
| | NME1-NME2 | Nucleoside diphosphate kinase. (268 aa) |
| | ATP5IF1 | ATP synthase inhibitory factor subunit 1. (96 aa) |
| | XBP1 | BZIP domain-containing protein. (412 aa) |
| | ATP5F1A | ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa) |
| | OSR2 | Uncharacterized protein. (883 aa) |
| | RTN4 | Reticulon. (1198 aa) |
| | CTNNB1 | Catenin beta 1. (782 aa) |
| | ALOX5 | Arachidonate 5-lipoxygenase. (630 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa) |
| | HSF4 | Heat shock transcription factor 4. (490 aa) |
| | CASK | Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (830 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (204 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (256 aa) |
| | TNMD | Tenomodulin. (318 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa) |
| | VASH1 | Vasohibin 1. (363 aa) |
| | IFT80 | Intraflagellar transport 80. (780 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (568 aa) |
| | WDR48 | WD repeat domain 48. (677 aa) |
| | IL26 | Interleukin 26. (171 aa) |
| | FGF1 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (155 aa) |
| | SLURP1 | UPAR/Ly6 domain-containing protein. (126 aa) |
| | SFRP2 | Secreted frizzled-related protein 2. (294 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (788 aa) |
| | PGF | Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (171 aa) |
| | STAT3 | Signal transducer and activator of transcription. (825 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (270 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | PDCD10 | Programmed cell death 10. (215 aa) |
| | GDF2 | Growth differentiation factor 2. (425 aa) |
| | KDR | Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa) |
| | SAAL1 | Serum amyloid A like 1. (473 aa) |
| | STAT5A | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. (788 aa) |
| | MMRN2 | Multimerin 2. (1002 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (534 aa) |
| | FLT4 | Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1303 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (785 aa) |
| | PTPRM | Protein tyrosine phosphatase receptor type M. (1402 aa) |
| | W5NQU8_SHEEP | Uncharacterized protein. (106 aa) |
| | PPP1R16B | Protein phosphatase 1 regulatory subunit 16B. (603 aa) |
| | BCL11B | BAF chromatin remodeling complex subunit BCL11B. (649 aa) |
| | W5PRT1_SHEEP | CTNNB1_binding domain-containing protein. (103 aa) |
| | WDR13 | WD repeat domain 13. (480 aa) |
| | FLT1 | Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1370 aa) |
| | GPC3 | Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (504 aa) |
| | FUT1 | L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (357 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1576 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4120 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1251 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (778 aa) |
| | HRH3 | Histamine receptor H3. (409 aa) |
| | CCR3 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (358 aa) |
| | SERPINF1 | SERPIN domain-containing protein; Belongs to the serpin family. (416 aa) |
| | EMC10 | Uncharacterized protein. (284 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1099 aa) |
| | GATA3 | GATA binding protein 3. (322 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa) |
| | PHOX2B | Uncharacterized protein. (116 aa) |
| | DAB2IP | DAB2 interacting protein. (1100 aa) |
| | W5PYL8_SHEEP | Uncharacterized protein. (173 aa) |
| | AR | Androgen receptor. (881 aa) |
| | IFT74 | Intraflagellar transport 74. (600 aa) |
| | PEX2 | Peroxisomal biogenesis factor 2. (305 aa) |
| | SOX2 | Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses n [...] (293 aa) |
| | NF1 | Neurofibromin 1. (2824 aa) |
| | JCAD | Junctional cadherin 5 associated. (1310 aa) |
| | HMX2 | Homeobox domain-containing protein. (104 aa) |
| | EPGN | Epithelial mitogen. (152 aa) |
| | ADAM17 | ADAM metallopeptidase domain 17. (825 aa) |
| | AGTR1 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | PAX2 | Paired box 2. (412 aa) |
| | APOH | Apolipoprotein H. (345 aa) |
| | PDCD6 | Uncharacterized protein. (160 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa) |
| | FGFR3 | Fibroblast growth factor receptor 3. (664 aa) |
| | MCC | MCC regulator of WNT signaling pathway. (847 aa) |
| | EPPK1 | Uncharacterized protein. (2384 aa) |
| | LIMS2 | LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (362 aa) |
| | MEF2C | MADS-box domain-containing protein. (463 aa) |
| | PAX6 | Paired box 6. (436 aa) |
| | INTU | Inturned planar cell polarity protein. (936 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (252 aa) |
| | SP1 | Sp1 transcription factor. (786 aa) |
| | ROBO1 | Uncharacterized protein. (1484 aa) |
| | KRT4 | Keratin 4; Belongs to the intermediate filament family. (559 aa) |
| | ITGA4 | Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1034 aa) |
| | OSR1 | Odd-skipped related transcription factor 1. (262 aa) |
| | AGGF1 | Uncharacterized protein. (714 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1. (613 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (386 aa) |
| | BMP6 | Bone morphogenetic protein 6. (340 aa) |
| | F3 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1013 aa) |
| | CCND1 | Cyclin_C domain-containing protein. (103 aa) |
| | THBS4 | Thrombospondin 4. (932 aa) |
| | FZD7 | Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (511 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1040 aa) |
| | KRIT1 | Uncharacterized protein. (738 aa) |
| | ARX | Aristaless related homeobox. (544 aa) |
| | OVOL1 | Ovo like transcriptional repressor 1. (267 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (454 aa) |
| | SRSF6-2 | RRM domain-containing protein. (267 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (165 aa) |
| | W5Q9P4_SHEEP | BZIP domain-containing protein. (372 aa) |
| | RREB1 | Ras responsive element binding protein 1. (1567 aa) |
| | W5QA57_SHEEP | MH1 domain-containing protein. (106 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (316 aa) |
| | SFN | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). (248 aa) |
| | KDM5B | Lysine demethylase 5B. (1496 aa) |
| | HMOX1 | Heme oxygenase 1. (271 aa) |
| | CDK6 | Cyclin dependent kinase 6. (273 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (559 aa) |
| | BMP2 | Bone morphogenetic protein 2. (425 aa) |
| | IFT57 | Intraflagellar transport 57. (428 aa) |
| | NRARP | NOTCH regulated ankyrin repeat protein. (90 aa) |
| | W5QCM7_SHEEP | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (528 aa) |
| | WNT2 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa) |
| | TGM1 | Transglutaminase 1. (786 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (456 aa) |
| | VDR | Vitamin D receptor. (424 aa) |
| | PROK1 | Prokineticin 1. (105 aa) |
| | WDR77 | WD repeat domain 77. (316 aa) |
| | AIMP1 | tRNA-binding domain-containing protein. (320 aa) |
| | SCG2 | Secretogranin II. (613 aa) |
| | GKN3P | Gastrokine 3, pseudogene. (185 aa) |
| | NRAS | NRAS proto-oncogene, GTPase. (189 aa) |
| | THBS1 | Thrombospondin 1. (1286 aa) |
| | EAF2 | ELL associated factor 2. (262 aa) |
| | PTPRN | Protein tyrosine phosphatase receptor type N. (954 aa) |
| | ST8SIA1 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa) |
| | W5QG65_SHEEP | Uncharacterized protein. (188 aa) |
| | DLL4 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (343 aa) |
| | FRS2 | Fibroblast growth factor receptor substrate 2. (508 aa) |
| | DLG1 | Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (248 aa) |
| | NOTCH2 | Notch receptor 2. (2471 aa) |
| | CLDN1 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (675 aa) |
| | TIE1 | Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1154 aa) |
| | COL4A3 | Collagen type IV alpha 3 chain. (1670 aa) |
| | ATOH8 | Atonal bHLH transcription factor 8. (262 aa) |
| | SAV1 | Salvador family WW domain containing protein 1. (384 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B. (538 aa) |
| | ECM1 | Extracellular matrix protein 1. (543 aa) |
| | CDKN1B | Cyclin dependent kinase inhibitor 1B. (198 aa) |
| | ALDH1A2 | Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa) |
| | W5QIG0_SHEEP | IRF tryptophan pentad repeat domain-containing protein. (387 aa) |
| | FGF7 | Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity); Belongs to the heparin-binding growth factors family. (194 aa) |
| | BMP4 | TGF_BETA_2 domain-containing protein. (409 aa) |
| | SIX1 | Homeobox domain-containing protein. (355 aa) |
| | SIX4 | SIX homeobox 4. (768 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (295 aa) |
| | W5QJ76_SHEEP | PDZ domain-containing protein. (124 aa) |
| | SOX9 | SRY-box transcription factor 9. (383 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1155 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | PTPRK | Protein tyrosine phosphatase receptor type K. (1369 aa) |
| | LAMA5 | Laminin subunit alpha 5. (3464 aa) |
| | BID | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (192 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa) |
| | CCL24 | C-C motif chemokine ligand 24. (116 aa) |
| | CCL26 | C-C motif chemokine. (69 aa) |
| | PKHD1 | PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4079 aa) |
| | PDCL3 | Phosducin like 3. (240 aa) |
| | DUSP10 | Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | HLX | Homeobox domain-containing protein. (241 aa) |
| | MST1 | Macrophage stimulating 1; Belongs to the peptidase S1 family. (836 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...] (616 aa) |
| | SNAI2 | Snai2. (268 aa) |
| | RNASE4 | Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (147 aa) |
| | KLF9 | Kruppel like factor 9. (241 aa) |
| | APLNR | Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (241 aa) |
| | IRF6 | IRF tryptophan pentad repeat domain-containing protein. (473 aa) |
| | NKX2-3 | NK2 homeobox 3. (267 aa) |
| | PPARD | Peroxisome proliferator activated receptor delta. (441 aa) |
| | TGFB2 | Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa) |
| | GHRL | Uncharacterized protein. (134 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3427 aa) |
| | TGFA | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa) |
| | GDF5 | Growth differentiation factor 5. (490 aa) |
| | PDX1 | Homeobox domain-containing protein. (85 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (454 aa) |
