STRINGSTRING
LOC101111303 LOC101111303 LGALS3 LGALS3 PPIB PPIB PTPRO PTPRO EPS8 EPS8 CCL20 CCL20 EDN2 EDN2 W5QFT0_SHEEP W5QFT0_SHEEP W5QFS8_SHEEP W5QFS8_SHEEP SCG2 SCG2 CSF3R CSF3R IRAK4 IRAK4 AIMP1 AIMP1 ANO6 ANO6 CXCR1 CXCR1 CSF1 CSF1 SPNS2 SPNS2 PIKFYVE PIKFYVE STAT5B STAT5B LBP LBP VAV3 VAV3 FER FER CRTAM CRTAM ARHGEF5 ARHGEF5 CXCL13 CXCL13 SLC12A2 SLC12A2 TRIM55 TRIM55 GPR183 GPR183 CXCL8-2 CXCL8-2 ITGA4 ITGA4 CXCL11 CXCL11 ITGB7 ITGB7 CXCL10 CXCL10 CRKL CRKL PDGFB PDGFB NCKAP1L NCKAP1L PAFAH1B1 PAFAH1B1 PLEC PLEC CXADR CXADR IL16 IL16 SELENOK SELENOK JAM2 JAM2 CH25H CH25H NEDD9 NEDD9 PECAM1 PECAM1 CCR7 CCR7 PF4 PF4 NF1 NF1 CXCL6 CXCL6 W5PYT1_SHEEP W5PYT1_SHEEP CXCL8 CXCL8 MYO1G MYO1G DPEP1 DPEP1 MCOLN2 MCOLN2 CX3CR1 CX3CR1 GATA3 GATA3 IL17A IL17A JAM3 JAM3 W5PVN6_SHEEP W5PVN6_SHEEP CHGA CHGA CCL24 CCL24 CCL26 CCL26 DOCK8 DOCK8 TRPM4 TRPM4 ANXA1 ANXA1 UMOD UMOD W5PSH9_SHEEP W5PSH9_SHEEP NKX2-3 NKX2-3 GP2 GP2 SLC37A4 SLC37A4 ITGB2 ITGB2 WNK1 WNK1 GOLPH3 GOLPH3 CRK CRK FLT1 FLT1 TRPM2 TRPM2 MSMP MSMP CXCR5 CXCR5 F2RL1 F2RL1 ITGA7 ITGA7 ADD2 ADD2 SELE SELE C5AR1 C5AR1 NUP85 NUP85 SELL SELL SELP SELP S1PR1 S1PR1 SBDS SBDS UMODL1 UMODL1 PREX1 PREX1 PDE4B PDE4B RABGEF1 RABGEF1 W5PLE2_SHEEP W5PLE2_SHEEP CNN2 CNN2 C10orf99 C10orf99 TAFA4 TAFA4 EXT1 EXT1 FUT4 FUT4 FCER1G FCER1G PTN PTN ELANE ELANE PRTN3 PRTN3 CCL2 CCL2 CCL11 CCL11 B4GALT1 B4GALT1 LOC101123184 LOC101123184 F11R F11R CCL8 CCL8 CCL1 CCL1 LOC101122122 LOC101122122 CCL19 CCL19 W5PH60_SHEEP W5PH60_SHEEP CCL21 CCL21 XCL1 XCL1 SLAMF1 SLAMF1 ROCK1 ROCK1 CD99L2 CD99L2 MADCAM1 MADCAM1 W5PFK3_SHEEP W5PFK3_SHEEP GAS6 GAS6 W5PFA4_SHEEP W5PFA4_SHEEP JAML JAML GCNT1 GCNT1 TBX21 TBX21 TNF TNF ITGA1 ITGA1 HSD3B7 HSD3B7 W5PEH4_SHEEP W5PEH4_SHEEP CD99 CD99 NINJ1 NINJ1 CDC42 CDC42 WDR1 WDR1 SLAMF8 SLAMF8 MMP9 MMP9 SYK SYK CXCL16 CXCL16 CXCL17 CXCL17 TNFSF11 TNFSF11 SRP54 SRP54 CNR2 CNR2 W5PAC7_SHEEP W5PAC7_SHEEP ITGAL ITGAL PIK3R1 PIK3R1 JAGN1 JAGN1 EMP2 EMP2 IL17RC IL17RC ITGA3 ITGA3 MSN MSN VAV1 VAV1 CCR6 CCR6 CCL16 CCL16 CCL14 CCL14 W5P3V8_SHEEP W5P3V8_SHEEP PLG PLG LOC100101238 LOC100101238 LOC101111035 LOC101111035 LOC101114535 LOC101114535 LOC101114285 LOC101114285 ADA ADA W5P1N4_SHEEP W5P1N4_SHEEP GBA GBA CORO1A CORO1A CCL25 CCL25 W5NYJ5_SHEEP W5NYJ5_SHEEP ALOX5 ALOX5 PLEC-2 PLEC-2 W5NXG9_SHEEP W5NXG9_SHEEP CKLF CKLF TREM1 TREM1 GPR15 GPR15 ITGA6 ITGA6 ITGA9 ITGA9 S100A8 S100A8 S100A9 S100A9 W5NPQ5_SHEEP W5NPQ5_SHEEP EDNRB EDNRB W5NPL3_SHEEP W5NPL3_SHEEP KIT KIT CCL22 CCL22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101111303C-C motif chemokine. (89 aa)
LGALS3Galectin. (249 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1221 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (845 aa)
CCL20C-C motif chemokine. (97 aa)
EDN2Endothelin 2. (180 aa)
W5QFT0_SHEEPUncharacterized protein. (175 aa)
W5QFS8_SHEEPUncharacterized protein. (159 aa)
SCG2Secretogranin II. (613 aa)
CSF3RColony stimulating factor 3 receptor. (843 aa)
IRAK4Protein kinase domain-containing protein. (460 aa)
AIMP1tRNA-binding domain-containing protein. (320 aa)
ANO6Anoctamin. (964 aa)
CXCR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (368 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
SPNS2Sphingolipid transporter 2. (638 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2109 aa)
STAT5BSignal transducer and activator of transcription. (791 aa)
LBPLipopolysaccharide binding protein. (540 aa)
VAV3Vav guanine nucleotide exchange factor 3. (847 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (825 aa)
CRTAMCytotoxic and regulatory T cell molecule. (390 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1623 aa)
CXCL13SCY domain-containing protein. (109 aa)
SLC12A2Solute carrier family 12 member 2. (1202 aa)
TRIM55Tripartite motif containing 55. (546 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (360 aa)
CXCL8-2Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (102 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1034 aa)
CXCL11C-X-C motif chemokine. (100 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CXCL10C-X-C motif chemokine. (102 aa)
CRKLCRK like proto-oncogene, adaptor protein. (305 aa)
PDGFBPlatelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] (252 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
PLECPlectin. (4278 aa)
CXADRUncharacterized protein. (365 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (1321 aa)
SELENOKSelenoprotein K. (92 aa)
JAM2Junctional adhesion molecule 2. (299 aa)
CH25HCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (272 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (768 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (812 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
PF4Platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation. (119 aa)
NF1Neurofibromin 1. (2824 aa)
CXCL6C-X-C motif chemokine. (109 aa)
W5PYT1_SHEEPUncharacterized protein. (650 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
MYO1GMyosin IG; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1019 aa)
DPEP1Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. In lung tissue, it may terminate or significantly reduce the leukotriene induced signal for bronchospasm. (499 aa)
MCOLN2Mucolipin 2. (624 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
GATA3GATA binding protein 3. (322 aa)
IL17AInterleukin-17A. (153 aa)
JAM3Junctional adhesion molecule 3. (329 aa)
W5PVN6_SHEEPProtein kinase domain-containing protein. (210 aa)
CHGAChromogranin A. (453 aa)
CCL24C-C motif chemokine ligand 24. (116 aa)
CCL26C-C motif chemokine. (69 aa)
DOCK8Dedicator of cytokinesis 8; Belongs to the DOCK family. (2101 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1202 aa)
ANXA1Annexin. (346 aa)
UMODUromodulin. (643 aa)
W5PSH9_SHEEPIg-like domain-containing protein. (250 aa)
NKX2-3NK2 homeobox 3. (267 aa)
GP2Glycoprotein 2. (533 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (750 aa)
WNK1WNK lysine deficient protein kinase 1. (2337 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
CRKCRK proto-oncogene, adaptor protein. (305 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1370 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1493 aa)
MSMPBeta-microseminoprotein. (139 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
F2RL1F2R like trypsin receptor 1. (368 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1187 aa)
ADD2Adducin 2. (721 aa)
SELEUncharacterized protein. (484 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (352 aa)
NUP85Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (657 aa)
SELLL-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. (383 aa)
SELPP-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. (769 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
SBDSSBDS ribosome maturation factor. (250 aa)
UMODL1Uromodulin like 1. (1346 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1596 aa)
PDE4BPhosphodiesterase. (544 aa)
RABGEF1Uncharacterized protein. (503 aa)
W5PLE2_SHEEPUncharacterized protein. (93 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (309 aa)
C10orf99Chromosome 10 open reading frame 99. (78 aa)
TAFA4TAFA chemokine like family member 4. (175 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (748 aa)
FUT4Fucosyltransferase 4. (364 aa)
FCER1GFc fragment of IgE receptor Ig. (85 aa)
PTNPleiotrophin. (168 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (259 aa)
PRTN3Proteinase 3; Belongs to the peptidase S1 family. (253 aa)
CCL2C-C motif chemokine. (115 aa)
CCL11C-C motif chemokine. (101 aa)
B4GALT1Uncharacterized protein. (402 aa)
LOC101123184tRNA-binding domain-containing protein. (322 aa)
F11RF11 receptor. (298 aa)
CCL8C-C motif chemokine. (110 aa)
CCL1SCY domain-containing protein. (97 aa)
LOC101122122SCY domain-containing protein. (109 aa)
CCL19C-C motif chemokine. (115 aa)
W5PH60_SHEEPtRNA-binding domain-containing protein. (323 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
XCL1SCY domain-containing protein. (112 aa)
SLAMF1Ig-like domain-containing protein. (378 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1372 aa)
CD99L2CD99 molecule like 2. (203 aa)
MADCAM1Adhes-Ig_like domain-containing protein. (378 aa)
W5PFK3_SHEEPtRNA-binding domain-containing protein. (264 aa)
GAS6Growth arrest specific 6. (594 aa)
W5PFA4_SHEEPUncharacterized protein. (53 aa)
JAMLJunction adhesion molecule like. (384 aa)
GCNT1Glucosaminyl (N-acetyl) transferase 1. (428 aa)
TBX21T-box transcription factor 21. (533 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1166 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (345 aa)
W5PEH4_SHEEPUncharacterized protein. (372 aa)
CD99CD99 molecule (Xg blood group). (189 aa)
NINJ1Ninjurin 1. (151 aa)
CDC42Cell division cycle 42. (237 aa)
WDR1WD repeat domain 1. (650 aa)
SLAMF8SLAM family member 8. (280 aa)
MMP9Matrix metallopeptidase 9. (700 aa)
SYKTyrosine-protein kinase. (633 aa)
CXCL16Uncharacterized protein. (255 aa)
CXCL17Uncharacterized protein. (53 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (249 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (504 aa)
CNR2Cannabinoid receptor 2; Belongs to the G-protein coupled receptor 1 family. (362 aa)
W5PAC7_SHEEPUncharacterized protein. (456 aa)
ITGALVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1164 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
JAGN1Jagunal homolog 1. (183 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
IL17RCInterleukin 17 receptor C. (708 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1039 aa)
MSNMoesin. (665 aa)
VAV1Vav guanine nucleotide exchange factor 1. (841 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
CCL16C-C motif chemokine ligand 16. (104 aa)
CCL14C-C motif chemokine ligand 14. (94 aa)
W5P3V8_SHEEPSCY domain-containing protein. (123 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (816 aa)
LOC100101238C-C motif chemokine. (89 aa)
LOC101111035C-C motif chemokine. (93 aa)
LOC101114535C-C motif chemokine. (93 aa)
LOC101114285C-C motif chemokine. (109 aa)
ADAAdenosine deaminase. (363 aa)
W5P1N4_SHEEPC-C motif chemokine. (93 aa)
GBAGlucosylceramidase. (536 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
CCL25SCY domain-containing protein. (150 aa)
W5NYJ5_SHEEPCu2_monoox_C domain-containing protein. (278 aa)
ALOX5Arachidonate 5-lipoxygenase. (630 aa)
PLEC-2Uncharacterized protein. (73 aa)
W5NXG9_SHEEPTNF_2 domain-containing protein. (153 aa)
CKLFChemokine like factor. (149 aa)
TREM1Triggering receptor expressed on myeloid cells 1. (232 aa)
GPR15G protein-coupled receptor 15; Belongs to the G-protein coupled receptor 1 family. (358 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1069 aa)
ITGA9Integrin subunit alpha 9; Belongs to the integrin alpha chain family. (1035 aa)
S100A8S100 calcium binding protein A8; Belongs to the S-100 family. (97 aa)
S100A9Protein S100; Belongs to the S-100 family. (133 aa)
W5NPQ5_SHEEPC-C motif chemokine. (102 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (456 aa)
W5NPL3_SHEEPSCY domain-containing protein. (433 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
CCL22C-C motif chemokine. (93 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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