6 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CSK	Tyrosine-protein kinase. (450 aa)
	CD226	CD226 molecule. (333 aa)
	RABGEF1	Uncharacterized protein. (503 aa)
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (693 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1235 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (645 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPL1	APPL2	ENSOARP00000015590	ENSOARP00000018492	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.987
APPL1	RABGEF1	ENSOARP00000015590	ENSOARP00000011273	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Uncharacterized protein.	0.498
APPL2	APPL1	ENSOARP00000018492	ENSOARP00000015590	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.987
CSK	PTPRC	ENSOARP00000003461	ENSOARP00000016883	Tyrosine-protein kinase.	Protein tyrosine phosphatase receptor type C.	0.400
PTPRC	CSK	ENSOARP00000016883	ENSOARP00000003461	Protein tyrosine phosphatase receptor type C.	Tyrosine-protein kinase.	0.400
RABGEF1	APPL1	ENSOARP00000011273	ENSOARP00000015590	Uncharacterized protein.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.498