STRINGSTRING
FN1 FN1 ATF2 ATF2 BMPR1A BMPR1A CDH3 CDH3 W5P265_SHEEP W5P265_SHEEP SMAD4 SMAD4 TYROBP TYROBP TSKU TSKU ITGB6 ITGB6 W5PCY8_SHEEP W5PCY8_SHEEP GATA6 GATA6 ITGB8 ITGB8 FOXP3 FOXP3 LTBP1 LTBP1 TGFB2 TGFB2 CD2AP CD2AP WNT11 WNT11 FURIN FURIN LRRC32 LRRC32 SERPINF2 SERPINF2 LUM LUM ITGAV ITGAV W5QA57_SHEEP W5QA57_SHEEP SMAD3 SMAD3 FERMT1 FERMT1 HIF1A HIF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FN1Fibronectin 1. (2478 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (534 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (776 aa)
W5P265_SHEEPUncharacterized protein. (236 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (109 aa)
TSKUTsukushi, small leucine rich proteoglycan. (360 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (787 aa)
W5PCY8_SHEEPUncharacterized protein. (183 aa)
GATA6GATA binding protein 6. (613 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (743 aa)
FOXP3Fork-head domain-containing protein. (474 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1517 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
CD2APCD2 associated protein. (638 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FURINP/Homo B domain-containing protein; Belongs to the peptidase S8 family. (712 aa)
LRRC32Leucine rich repeat containing 32. (663 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
LUMLumican. (342 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
W5QA57_SHEEPMH1 domain-containing protein. (106 aa)
SMAD3Mothers against decapentaplegic homolog. (316 aa)
FERMT1Fermitin family member 1. (689 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (841 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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