STRINGSTRING
LOC101110103 LOC101110103 CD1 CD1 CD1E CD1E LOC101111409 LOC101111409 TLR2 TLR2 LBP LBP CD14 CD14 W5NX80_SHEEP W5NX80_SHEEP W5NV90_SHEEP W5NV90_SHEEP W5NV86_SHEEP W5NV86_SHEEP LOC443441 LOC443441 TLR6 TLR6 TLR1 TLR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC101110103Ig-like domain-containing protein. (346 aa)
CD1T-cell surface glycoprotein CD1b-1; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. (333 aa)
CD1ECD1e molecule. (392 aa)
LOC101111409Ig-like domain-containing protein. (339 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
LBPLipopolysaccharide binding protein. (540 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)
W5NX80_SHEEPIg-like domain-containing protein. (337 aa)
W5NV90_SHEEPMHC_I-like_Ag-recog domain-containing protein. (203 aa)
W5NV86_SHEEPIGc1 domain-containing protein. (95 aa)
LOC443441Ig-like domain-containing protein. (232 aa)
TLR6Toll-like receptor. (797 aa)
TLR1Toll-like receptor. (796 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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