STRINGSTRING
W5PH02_SHEEP W5PH02_SHEEP KCNMA1 KCNMA1 ATP1B1 ATP1B1 ENO1 ENO1 MTPN MTPN GRK2 GRK2 ADRA1A ADRA1A NPNT NPNT MEF2A MEF2A FBXO32 FBXO32 DMPK DMPK ADRA1B ADRA1B W5PLE2_SHEEP W5PLE2_SHEEP PDE4B PDE4B CALM3 CALM3 ADRA2A ADRA2A FOXO3 FOXO3 ADA ADA SLC9A1 SLC9A1 NOTCH1 NOTCH1 RYR2 RYR2 SMAD7 SMAD7 BECN1 BECN1 MYMK MYMK SRL SRL W5NYC3_SHEEP W5NYC3_SHEEP DOCK4 DOCK4 TIFAB TIFAB KCNQ1 KCNQ1 NOL3 NOL3 W5NVU9_SHEEP W5NVU9_SHEEP W5NVT1_SHEEP W5NVT1_SHEEP ATP2A1 ATP2A1 W5NVA2_SHEEP W5NVA2_SHEEP TNNT1 TNNT1 TNNI3 TNNI3 W5NUL6_SHEEP W5NUL6_SHEEP SCN10A SCN10A MYLK2 MYLK2 SCN5A SCN5A CAV1 CAV1 CHRM2 CHRM2 CHRNB4 CHRNB4 TRPC3 TRPC3 MYOG MYOG PARP1 PARP1 ASB15 ASB15 TNNT3 TNNT3 RANGRF RANGRF CTTN CTTN SETD3 SETD3 W5PM90_SHEEP W5PM90_SHEEP W5PMM1_SHEEP W5PMM1_SHEEP PDE9A PDE9A ANKRD66 ANKRD66 DLG1 DLG1 EDN2 EDN2 SPX SPX ATP1A1 ATP1A1 CASQ2 CASQ2 PLN PLN BMP10 BMP10 ZC3H12A ZC3H12A PRKAG3 PRKAG3 TWF1 TWF1 UCN UCN MYH7 MYH7 PKP2 PKP2 HCN4 HCN4 W5QBX2_SHEEP W5QBX2_SHEEP TNNI1 TNNI1 HDAC4 HDAC4 TMEM38A TMEM38A CAMK2D CAMK2D GPER1 GPER1 P2RX1 P2RX1 FKBP1B FKBP1B CHRM3 CHRM3 KBTBD13 KBTBD13 W5Q8F9_SHEEP W5Q8F9_SHEEP ADORA2B ADORA2B JUP JUP CMYA5 CMYA5 TNFRSF1B TNFRSF1B AKAP9 AKAP9 F2R F2R W5Q4M2_SHEEP W5Q4M2_SHEEP ATP2A2 ATP2A2 W5Q3L8_SHEEP W5Q3L8_SHEEP IGF1 IGF1 PRKCA PRKCA ATP2B1 ATP2B1 MYOCD MYOCD HAND2 HAND2 ANKRD28 ANKRD28 ANKRD44 ANKRD44 P2RX4 P2RX4 GLRX3 GLRX3 PAWR PAWR W5PZE6_SHEEP W5PZE6_SHEEP W5PZE0_SHEEP W5PZE0_SHEEP W5PYK2_SHEEP W5PYK2_SHEEP ADRB2 ADRB2 PI16 PI16 SCN4A SCN4A EDN1 EDN1 ZDHHC21 ZDHHC21 RHOA RHOA KCNJ2 KCNJ2 PPP3CA PPP3CA PRKG1 PRKG1 CACNA1C CACNA1C RNF207 RNF207 GTF2IRD1 GTF2IRD1 SRI SRI GJA5 GJA5 TBXA2R TBXA2R W5PRX3_SHEEP W5PRX3_SHEEP ORMDL3 ORMDL3 ACE2 ACE2 HRC HRC TRPM4 TRPM4 GATA5 GATA5 SOD1-2 SOD1-2 TNNC1 TNNC1 SMAD4 SMAD4 CTNNA3 CTNNA3 W5P3S6_SHEEP W5P3S6_SHEEP SGCA SGCA C12orf57 C12orf57 DLG2 DLG2 LMNA LMNA TNFRSF1A TNFRSF1A TACR2 TACR2 SRF SRF SELENON SELENON DSG2 DSG2 ACTN3 ACTN3 MLIP MLIP DSC2 DSC2 MYL3 MYL3 PDE4D PDE4D TMEM38B TMEM38B SPHK1 SPHK1 CAV3 CAV3 ARHGAP42 ARHGAP42 LMCD1 LMCD1 SOD1 SOD1 GSK3A GSK3A ANXA6 ANXA6 ATP1A2 ATP1A2 CAMK2G CAMK2G CASQ1 CASQ1 ROCK1 ROCK1 ATP2B4 ATP2B4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5PH02_SHEEPCation_ATPase_N domain-containing protein. (245 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1073 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (303 aa)
ENO1Enolase 1. (452 aa)
MTPNMyotrophin. (119 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (606 aa)
ADRA1AAdrenoceptor alpha 1A. (432 aa)
NPNTNephronectin. (599 aa)
MEF2AMyocyte enhancer factor 2A. (500 aa)
FBXO32F-box protein 32. (355 aa)
DMPKDM1 protein kinase. (513 aa)
ADRA1BAdrenoceptor alpha 1B. (296 aa)
W5PLE2_SHEEPUncharacterized protein. (93 aa)
PDE4BPhosphodiesterase. (544 aa)
CALM3Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). (149 aa)
ADRA2AAdrenoceptor alpha 2A. (391 aa)
FOXO3Fork-head domain-containing protein. (473 aa)
ADAAdenosine deaminase. (363 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (920 aa)
NOTCH1Notch receptor 1. (2008 aa)
RYR2Ryanodine receptor 2. (4788 aa)
SMAD7MH2 domain-containing protein. (257 aa)
BECN1Beclin 1. (448 aa)
MYMKMyomaker, myoblast fusion factor. (211 aa)
SRLSarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (797 aa)
W5NYC3_SHEEPUncharacterized protein. (189 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1973 aa)
TIFABUncharacterized protein. (122 aa)
KCNQ1Ion_trans domain-containing protein; Belongs to the potassium channel family. (383 aa)
NOL3Nucleolar protein 3. (196 aa)
W5NVU9_SHEEPUncharacterized protein. (147 aa)
W5NVT1_SHEEPCation_ATPase_C domain-containing protein. (188 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1063 aa)
W5NVA2_SHEEPNMU domain-containing protein. (137 aa)
TNNT1Troponin T1, slow skeletal type. (262 aa)
TNNI3Troponin I3, cardiac type. (212 aa)
W5NUL6_SHEEPCation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (369 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1969 aa)
MYLK2Myosin light chain kinase 2. (626 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1932 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (465 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (497 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (843 aa)
MYOGBASIC domain-containing protein. (194 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1016 aa)
ASB15Ankyrin repeat and SOCS box containing 15. (606 aa)
TNNT3Troponin T3, fast skeletal type. (223 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
CTTNCortactin. (511 aa)
SETD3Protein-histidine N-methyltransferase. (588 aa)
W5PM90_SHEEPUncharacterized protein. (265 aa)
W5PMM1_SHEEPUncharacterized protein. (249 aa)
PDE9APhosphodiesterase. (554 aa)
ANKRD66Ankyrin repeat domain 66. (203 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
EDN2Endothelin 2. (180 aa)
SPXSpexin hormone. (116 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. (1021 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (431 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (433 aa)
PRKAG3Uncharacterized protein. (523 aa)
TWF1Twinfilin actin binding protein 1. (384 aa)
UCNUrocortin. (129 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
PKP2Plakophilin 2. (829 aa)
HCN4Cyclic nucleotide-binding domain-containing protein. (774 aa)
W5QBX2_SHEEPUncharacterized protein. (238 aa)
TNNI1Troponin I1, slow skeletal type. (189 aa)
HDAC4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (950 aa)
TMEM38ATransmembrane protein 38A. (330 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (168 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
CHRM3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
KBTBD13Kelch repeat and BTB domain containing 13. (352 aa)
W5Q8F9_SHEEPUncharacterized protein. (115 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
JUPJunction plakoglobin. (747 aa)
CMYA5Cardiomyopathy associated 5. (3937 aa)
TNFRSF1BTNF receptor superfamily member 1B. (460 aa)
AKAP9A-kinase anchoring protein 9. (3899 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (421 aa)
W5Q4M2_SHEEPUncharacterized protein. (193 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1058 aa)
W5Q3L8_SHEEPUncharacterized protein. (368 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
MYOCDMyocardin. (980 aa)
HAND2Heart and neural crest derivatives expressed 2. (129 aa)
ANKRD28Ankyrin repeat domain 28. (1087 aa)
ANKRD44Ankyrin repeat domain 44. (1041 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (385 aa)
GLRX3Glutaredoxin 3. (314 aa)
PAWRUncharacterized protein. (168 aa)
W5PZE6_SHEEPNMU domain-containing protein. (99 aa)
W5PZE0_SHEEPUncharacterized protein. (85 aa)
W5PYK2_SHEEPEnolase_C domain-containing protein. (317 aa)
ADRB2G_PROTEIN_RECEP_F1_2 domain-containing protein. (419 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (464 aa)
SCN4ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1804 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (215 aa)
ZDHHC21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
RHOARHOA. (193 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
PPP3CASerine/threonine-protein phosphatase. (471 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (471 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2147 aa)
RNF207Ring finger protein 207. (625 aa)
GTF2IRD1GTF2I repeat domain containing 1. (1003 aa)
SRIUncharacterized protein. (209 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (359 aa)
TBXA2RThromboxane A2 receptor. (305 aa)
W5PRX3_SHEEPUncharacterized protein. (835 aa)
ORMDL3ORMDL sphingolipid biosynthesis regulator 3. (207 aa)
ACE2Angiotensin-converting enzyme. (805 aa)
HRCHistidine rich calcium binding protein. (730 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1202 aa)
GATA5GATA binding protein 5. (423 aa)
SOD1-2Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
CTNNA3Catenin alpha 3. (560 aa)
W5P3S6_SHEEPUncharacterized protein. (157 aa)
SGCASarcoglycan alpha. (389 aa)
C12orf57Chromosome 12 open reading frame 57. (112 aa)
DLG2Discs large MAGUK scaffold protein 2. (905 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (658 aa)
TNFRSF1AUncharacterized protein. (277 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (390 aa)
SRFSerum response factor. (353 aa)
SELENONSelenoprotein N. (487 aa)
DSG2Desmoglein 2. (1125 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (897 aa)
MLIPMuscular LMNA interacting protein. (1045 aa)
DSC2Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (909 aa)
MYL3Myosin light chain 3. (199 aa)
PDE4DPhosphodiesterase. (674 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
SPHK1Sphingosine kinase 1. (459 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (177 aa)
ARHGAP42Rho GTPase activating protein 42. (872 aa)
LMCD1LIM and cysteine rich domains 1. (360 aa)
SOD1Superoxide dismutase 1. (152 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (451 aa)
ANXA6Annexin. (753 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (547 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (396 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1372 aa)
ATP2B4Uncharacterized protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (478 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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