Your Input: | |
| | MEAF6 | MYST/Esa1 associated factor 6. (184 aa) |
| | SPDL1 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (603 aa) |
| | CTCF | CCCTC-binding factor. (730 aa) |
| | NUP133 | Nucleoporin_C domain-containing protein. (1157 aa) |
| | ACD | ACD shelterin complex subunit and telomerase recruitment factor. (509 aa) |
| | W5NYT6_SHEEP | Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (251 aa) |
| | CENPT | Centromere protein T. (566 aa) |
| | AHCTF1 | AT-hook containing transcription factor 1. (2297 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | DHX36 | DEAH-box helicase 36. (1065 aa) |
| | TERF2 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (502 aa) |
| | FBXW11 | F-box and WD repeat domain containing 11. (531 aa) |
| | DYNC1I1 | Dynein cytoplasmic 1 intermediate chain 1. (628 aa) |
| | CHRAC1 | CBFD_NFYB_HMF domain-containing protein. (130 aa) |
| | CHMP2A | Charged multivesicular body protein 2A. (222 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1030 aa) |
| | SPC25 | SPC25 component of NDC80 kinetochore complex. (226 aa) |
| | W5P234_SHEEP | Uncharacterized protein. (106 aa) |
| | CKAP5 | Cytoskeleton associated protein 5. (2075 aa) |
| | PML | Promyelocytic leukemia. (847 aa) |
| | MIS12 | Uncharacterized protein. (206 aa) |
| | LAGE3 | L antigen family member 3. (150 aa) |
| | SKA1 | Spindle and kinetochore associated complex subunit 1. (255 aa) |
| | THOC5 | THO complex 5. (683 aa) |
| | HELLS | Helicase, lymphoid specific. (837 aa) |
| | CENPB | Major centromere autoantigen B; Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes. (596 aa) |
| | STN1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (381 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (211 aa) |
| | SEPTIN7 | Septin 7; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (418 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (741 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1062 aa) |
| | CENPS | Centromere protein S. (139 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (863 aa) |
| | W5P5N5_SHEEP | Uncharacterized protein. (163 aa) |
| | TRAPPC12 | Trafficking protein particle complex 12. (634 aa) |
| | TERF1 | Telomeric repeat binding factor 1. (342 aa) |
| | CSNK1A1 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (337 aa) |
| | BIRC5 | Baculoviral IAP repeat containing 5. (142 aa) |
| | POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1175 aa) |
| | CBX1 | Uncharacterized protein. (185 aa) |
| | LOC101102276 | Uncharacterized protein. (201 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (709 aa) |
| | WDR82 | WD repeat domain 82. (313 aa) |
| | CENPH | Centromere protein H. (244 aa) |
| | ERCC6L | ERCC excision repair 6 like, spindle assembly checkpoint helicase. (1223 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (299 aa) |
| | ZNF618 | Zinc finger protein 618. (930 aa) |
| | W5P8I1_SHEEP | Uncharacterized protein. (145 aa) |
| | DCTN2 | Dynactin subunit 2. (408 aa) |
| | CENPK | Centromere protein K. (271 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2361 aa) |
| | CENPC | Centromere protein C; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions; Belongs to the CENP-C/MIF2 family. (944 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1529 aa) |
| | TERF2IP | TERF2 interacting protein. (367 aa) |
| | ANAPC16 | Anaphase promoting complex subunit 16. (110 aa) |
| | TTK | TTK protein kinase. (856 aa) |
| | W5PBL9_SHEEP | Uncharacterized protein. (185 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | CHD4 | Uncharacterized protein. (1881 aa) |
| | SUV39H2 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (430 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (338 aa) |
| | CENPU | Centromere protein U. (416 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (755 aa) |
| | CENPW | Centromere protein W. (103 aa) |
| | NUP160 | Nucleoporin 160. (1414 aa) |
| | PHF2 | PHD finger protein 2. (1130 aa) |
| | NCAPD2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1394 aa) |
| | CENPP | Centromere protein P. (288 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (277 aa) |
| | CENPF | Centromere protein F. (3260 aa) |
| | KDM4B | Lysine demethylase 4B. (1112 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division 1 like 1. (2919 aa) |
| | ZBTB10 | Zinc finger and BTB domain containing 10. (864 aa) |
| | TEN1 | Uncharacterized protein. (122 aa) |
| | ZNF827 | Zinc finger protein 827. (1074 aa) |
| | SMC1A | Structural maintenance of chromosomes protein. (1233 aa) |
| | NDE1 | NudE neurodevelopment protein 1. (350 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (632 aa) |
| | KAT8 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (458 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2463 aa) |
| | BOD1 | Uncharacterized protein. (159 aa) |
| | CHAMP1 | Chromosome alignment maintaining phosphoprotein 1. (781 aa) |
| | DCTN3 | Dynactin subunit 3. (191 aa) |
| | THOC1 | THO complex 1. (661 aa) |
| | SPOUT1 | SPOUT domain containing methyltransferase 1. (380 aa) |
| | KNTC1 | Kinetochore associated 1. (2242 aa) |
| | BUB3 | WD_REPEATS_REGION domain-containing protein. (328 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (546 aa) |
| | CHMP5 | Uncharacterized protein. (221 aa) |
| | DAXX | Death domain associated protein. (762 aa) |
| | W5PIJ1_SHEEP | Vert_HS_TF domain-containing protein. (447 aa) |
| | NDC80 | NDC80 kinetochore complex component. (642 aa) |
| | FMR1 | Fragile X mental retardation 1. (632 aa) |
| | ITGB3BP | Uncharacterized protein. (212 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | NABP2 | Nucleic acid binding protein 2. (154 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1872 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (483 aa) |
| | GPATCH11 | G-patch domain containing 11. (262 aa) |
| | W5PJN9_SHEEP | Uncharacterized protein. (296 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (299 aa) |
| | CBX3 | Uncharacterized protein. (185 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1974 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1231 aa) |
| | CHMP7 | Charged multivesicular body protein 7. (452 aa) |
| | NSL1 | NSL1 component of MIS12 kinetochore complex. (283 aa) |
| | DCTN6 | Dynactin subunit 6. (196 aa) |
| | RAD21 | RAD21 cohesin complex component. (630 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1276 aa) |
| | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1057 aa) |
| | SIRT6 | Sirtuin 6. (361 aa) |
| | ZNF207 | Zinc finger protein 207. (495 aa) |
| | CDK2 | Protein kinase domain-containing protein. (298 aa) |
| | W5PM25_SHEEP | Uncharacterized protein. (162 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1084 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (757 aa) |
| | RCC2 | Regulator of chromosome condensation 2. (485 aa) |
| | NUP85 | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (657 aa) |
| | W5PMZ0_SHEEP | Uncharacterized protein. (1538 aa) |
| | W5PN40_SHEEP | Uncharacterized protein. (2268 aa) |
| | W5PN51_SHEEP | Uncharacterized protein. (219 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3427 aa) |
| | NUF2 | NUF2 component of NDC80 kinetochore complex. (465 aa) |
| | PPP1CA | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa) |
| | THOC7 | THO complex 7. (198 aa) |
| | ZBTB48 | Zinc finger and BTB domain containing 48. (672 aa) |
| | NEK2 | NIMA related kinase 2. (439 aa) |
| | SEC13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (322 aa) |
| | CHEK1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3057 aa) |
| | SKA2 | Spindle and kinetochore associated complex subunit 2. (120 aa) |
| | SUV39H1 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (412 aa) |
| | PHF6 | PHD finger protein 6. (366 aa) |
| | CENPQ | Centromere protein Q. (271 aa) |
| | ZNF330 | Zinc finger protein 330. (322 aa) |
| | W5PRV2_SHEEP | Chromo domain-containing protein. (145 aa) |
| | W5PSD0_SHEEP | CBFD_NFYB_HMF domain-containing protein. (119 aa) |
| | DCTN1 | CAP-Gly domain-containing protein. (1297 aa) |
| | CENPL | Centromere protein L. (346 aa) |
| | BAZ1B | Bromodomain adjacent to zinc finger domain 1B. (1456 aa) |
| | PPP1R10 | Protein phosphatase 1 regulatory subunit 10. (911 aa) |
| | W5PTL5_SHEEP | WD_REPEATS_REGION domain-containing protein. (416 aa) |
| | BLM | BLM RecQ like helicase. (1429 aa) |
| | SMC5 | SMC_N domain-containing protein. (1167 aa) |
| | RECQL4 | RecQ like helicase 4. (1105 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (564 aa) |
| | W5PTW7_SHEEP | Uncharacterized protein. (185 aa) |
| | ZWINT | ZW10 interacting kinetochore protein. (286 aa) |
| | SNAI1 | Snail family transcriptional repressor 1. (348 aa) |
| | CLASP1 | Cytoplasmic linker associated protein 1. (1463 aa) |
| | NCAPD3 | Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1398 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (471 aa) |
| | CEBPB | BZIP domain-containing protein. (126 aa) |
| | LOC101117679 | Uncharacterized protein. (206 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (490 aa) |
| | KIF2B | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (682 aa) |
| | SKA3 | Spindle and kinetochore associated complex subunit 3. (417 aa) |
| | MIS18A | MIS18 kinetochore protein A. (207 aa) |
| | POLD1 | DNA polymerase. (1047 aa) |
| | NABP1 | Nucleic acid binding protein 1. (208 aa) |
| | DOT1L | Histone-lysine N-methyltransferase, H3 lysine-79 specific. (1721 aa) |
| | W5PXP9_SHEEP | HSF_DOMAIN domain-containing protein. (431 aa) |
| | CHMP1A | Charged multivesicular body protein 1A. (196 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (739 aa) |
| | BUB1 | BUB1 mitotic checkpoint serine/threonine kinase. (1081 aa) |
| | TOP2A | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1546 aa) |
| | ZNF276 | Zinc finger protein 276. (541 aa) |
| | W5PYF0_SHEEP | Shugoshin_C domain-containing protein. (378 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (451 aa) |
| | W5PYU1_SHEEP | FHA domain-containing protein. (3257 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | INCENP | Inner centromere protein. (866 aa) |
| | CHMP4C | Charged multivesicular body protein 4C. (236 aa) |
| | ESCO2 | Establishment of sister chromatid cohesion N-acetyltransferase 2. (734 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1444 aa) |
| | HMBOX1 | Homeobox containing 1. (420 aa) |
| | PPP2R1A | Protein phosphatase 2 scaffold subunit Aalpha. (559 aa) |
| | PPP1R12A | Protein phosphatase 1 regulatory subunit. (1029 aa) |
| | FAM193A | Family with sequence similarity 193 member A. (1202 aa) |
| | KMT5B | Lysine methyltransferase 5B. (904 aa) |
| | PINX1 | PIN2 (TERF1) interacting telomerase inhibitor 1. (311 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (460 aa) |
| | KIF18A | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (895 aa) |
| | SYCP3 | Synaptonemal complex protein 3. (225 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (657 aa) |
| | DNMT1 | DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1733 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (342 aa) |
| | NUP37 | Nucleoporin 37. (326 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (372 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (211 aa) |
| | W5Q2H9_SHEEP | WD_REPEATS_REGION domain-containing protein. (324 aa) |
| | KAT2B | Lysine acetyltransferase 2B. (747 aa) |
| | FBXO28 | F-box protein 28. (371 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (539 aa) |
| | SGO1 | Shugoshin_C domain-containing protein. (521 aa) |
| | SUN2 | Sad1 and UNC84 domain containing 2. (804 aa) |
| | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa) |
| | SGO2 | Shugoshin 2. (1245 aa) |
| | W5Q3D8_SHEEP | Uncharacterized protein. (1464 aa) |
| | SEPTIN6 | Septin 6; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (444 aa) |
| | APC | APC regulator of WNT signaling pathway. (2856 aa) |
| | DSN1 | DSN1 component of MIS12 kinetochore complex. (412 aa) |
| | CBX5 | Chromobox-like protein 5. (190 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (324 aa) |
| | PGRMC1 | Uncharacterized protein. (87 aa) |
| | W5Q4H0_SHEEP | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (606 aa) |
| | RASSF2 | Ras association domain family member 2. (326 aa) |
| | THOC3 | THO complex 3. (351 aa) |
| | SMC6 | Structural maintenance of chromosomes 6. (1101 aa) |
| | ORC2 | Origin recognition complex subunit 2. (576 aa) |
| | W5Q5M6_SHEEP | Chromo domain-containing protein. (110 aa) |
| | CHMP2B | Charged multivesicular body protein 2B. (213 aa) |
| | W5Q6B9_SHEEP | GFA domain-containing protein. (217 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (605 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (304 aa) |
| | MTBP | MDM2 binding protein. (926 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (543 aa) |
| | SPC24 | SPC24 component of NDC80 kinetochore complex. (221 aa) |
| | TERF2IP-2 | Telomeric repeat-binding factor 2-interacting protein 1. (44 aa) |
| | SEPTIN2 | Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (358 aa) |
| | SPO11 | SPO11 initiator of meiotic double stranded breaks. (395 aa) |
| | CENPO | Uncharacterized protein. (296 aa) |
| | W5Q9M6_SHEEP | WD_REPEATS_REGION domain-containing protein. (414 aa) |
| | RANGAP1 | Ran GTPase activating protein 1. (622 aa) |
| | ZWILCH | Zwilch kinetochore protein. (589 aa) |
| | ZW10 | Zw10 kinetochore protein. (782 aa) |
| | DNMT3A | DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (948 aa) |
| | ATRX | ATRX chromatin remodeler. (2451 aa) |
| | W5QBP5_SHEEP | SER_THR_PHOSPHATASE domain-containing protein. (183 aa) |
| | CENPM | Centromere protein M. (180 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (263 aa) |
| | W5QBZ2_SHEEP | Uncharacterized protein. (289 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (514 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (406 aa) |
| | CTC1 | CST telomere replication complex component 1. (1230 aa) |
| | TINF2 | TERF1 interacting nuclear factor 2. (456 aa) |
| | MDP1 | Uncharacterized protein. (165 aa) |
| | HJURP | Holliday junction recognition protein. (699 aa) |
| | REC8 | REC8 meiotic recombination protein. (592 aa) |
| | NGDN | Neuroguidin. (320 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (733 aa) |
| | SMC1B | Structural maintenance of chromosomes protein. (1235 aa) |
| | LRIF1 | Ligand dependent nuclear receptor interacting factor 1. (763 aa) |
| | PPP1CB | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa) |
| | W5QE97_SHEEP | Chromo domain-containing protein. (151 aa) |
| | TOX4 | TOX high mobility group box family member 4. (619 aa) |
| | TEP1 | Telomerase associated protein 1. (2621 aa) |
| | CDCA8 | Cell division cycle associated 8. (280 aa) |
| | DCLRE1B | DNA cross-link repair 1B. (541 aa) |
| | BUB1B | Uncharacterized protein. (1062 aa) |
| | XPO1 | Exportin 1. (1072 aa) |
| | KNSTRN | Kinetochore localized astrin (SPAG5) binding protein. (358 aa) |
| | KNL1 | Kinetochore scaffold 1. (2344 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | OIP5 | Opa interacting protein 5. (233 aa) |
| | LOC101107266 | Uncharacterized protein. (222 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa) |
| | RBBP4 | WD_REPEATS_REGION domain-containing protein. (425 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (279 aa) |
| | DYNLT3 | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity). (116 aa) |
| | WRN | WRN RecQ like helicase. (1406 aa) |
| | NUP107 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (937 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa) |
| | CHMP6 | Charged multivesicular body protein 6. (180 aa) |
| | KDM4A | Uncharacterized protein. (1071 aa) |
| | THOC6 | THO complex 6. (341 aa) |
| | SPAG5 | Sperm associated antigen 5. (1194 aa) |
| | KIF2C | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (724 aa) |
| | TFIP11 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (833 aa) |
| | NDEL1 | NudE neurodevelopment protein 1 like 1. (408 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (444 aa) |
| | CENPI | Centromere protein I. (740 aa) |
| | RSKR | Ribosomal protein S6 kinase related. (278 aa) |
| | KMT5C | Lysine methyltransferase 5C. (424 aa) |
| | GATAD2B | GATA zinc finger domain containing 2B. (592 aa) |
| | POT1 | Protection of telomeres 1. (785 aa) |
| | HAT1 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. (416 aa) |
| | W5NV67_SHEEP | Uncharacterized protein. (87 aa) |
| | NLRP2 | NLR family pyrin domain containing 2. (1072 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1288 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1732 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa) |
| | NUP98 | Nucleoporin 98. (1816 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | TERB1 | Telomere repeat binding bouquet formation protein 1. (732 aa) |
| | MAD1L1 | Uncharacterized protein. (208 aa) |
| | WRNIP1 | AAA domain-containing protein. (228 aa) |
| | CHEK2 | Checkpoint kinase 2. (536 aa) |
| | W5NX37_SHEEP | Uncharacterized protein. (714 aa) |
| | W5NXR8_SHEEP | Uncharacterized protein. (137 aa) |
| | NUP43 | Nucleoporin 43. (380 aa) |
| | RASSF4 | Ras association domain family member 4. (317 aa) |
