(73 nodes) Vesicle tethering complex network (Ovis aries)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRAPPC9	Trafficking protein particle complex 9. (1117 aa)
	EXOC6	Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (797 aa)
	W5NTF7_SHEEP	Uncharacterized protein. (130 aa)
	EXOC1L	Exocyst complex component 1 like. (172 aa)
	EXOC1	Exocyst complex component 1. (901 aa)
	TRAPPC5	Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (190 aa)
	VIPAS39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog. (500 aa)
	W5NX32_SHEEP	Uncharacterized protein. (482 aa)
	EXOC3L1	Exocyst complex component 3 like 1. (739 aa)
	COG2	Component of oligomeric golgi complex 2. (735 aa)
	EXOC8	Exocyst complex component 8. (672 aa)
	EXOC2	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (925 aa)
	RINT1	RAD50 interactor 1. (788 aa)
	COG8	Conserved oligomeric Golgi complex subunit 8; Belongs to the COG8 family. (513 aa)
	HOOK3	Hook microtubule tethering protein 3. (719 aa)
	W5P2E8_SHEEP	Uncharacterized protein. (128 aa)
	STXBP6	Syntaxin binding protein 6. (210 aa)
	COG4	Component of oligomeric golgi complex 4. (787 aa)
	VPS16	Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (839 aa)
	COG5	Component of oligomeric golgi complex 5. (858 aa)
	EIPR1	EARP complex and GARP complex interacting protein 1. (353 aa)
	TRAPPC12	Trafficking protein particle complex 12. (634 aa)
	W5P647_SHEEP	Uncharacterized protein. (234 aa)
	W5P676_SHEEP	Uncharacterized protein. (407 aa)
	TRAPPC13	Trafficking protein particle complex 13. (419 aa)
	TRAPPC8	Trafficking protein particle complex 8. (1436 aa)
	W5P9Y9_SHEEP	Sec8_exocyst domain-containing protein. (385 aa)
	EXOC4	Uncharacterized protein. (408 aa)
	RNF215	Ring finger protein 215. (355 aa)
	TRAPPC11	Trafficking protein particle complex 11. (1130 aa)
	COG3	Component of oligomeric golgi complex 3. (773 aa)
	DNAJC28	DnaJ heat shock protein family (Hsp40) member C28. (386 aa)
	EXOC7	Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (733 aa)
	CDC42	Cell division cycle 42. (237 aa)
	HOOK1	Hook microtubule tethering protein 1. (733 aa)
	TRAPPC6B	Trafficking protein particle complex 6B. (158 aa)
	VPS52	VPS52 subunit of GARP complex. (724 aa)
	TRAPPC3L	Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (182 aa)
	COG6	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function. (663 aa)
	TRAPPC6A	Trafficking protein particle complex 6A. (159 aa)
	EXOC3L2	Exocyst complex component 3 like 2. (410 aa)
	W5PLE3_SHEEP	Uncharacterized protein. (46 aa)
	W5PMH3_SHEEP	Sec8_exocyst domain-containing protein. (368 aa)
	STX17	Syntaxin 17; Belongs to the syntaxin family. (302 aa)
	HOOK2	Hook microtubule tethering protein 2. (719 aa)
	TRAPPC2B	Trafficking protein particle complex 2B. (140 aa)
	VPS33A	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
	TRAPPC10	Foie-gras_1 domain-containing protein. (1265 aa)
	EXOC6B	Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (811 aa)
	VPS53	VPS53 subunit of GARP complex. (832 aa)
	VPS33B	Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (617 aa)
	VPS51	VPS51 subunit of GARP complex. (788 aa)
	TRAPPC4	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (219 aa)
	VPS11	Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family. (938 aa)
	TGFBRAP1	Transforming growth factor beta receptor associated protein 1. (843 aa)
	TRAPPC2L	Trafficking protein particle complex 2 like. (137 aa)
	COG1	Component of oligomeric golgi complex 1. (932 aa)
	SH3BP1	Uncharacterized protein. (694 aa)
	EXOC3	Exocyst complex component 3. (750 aa)
	NBAS	Neuroblastoma amplified sequence. (2334 aa)
	COG7	Component of oligomeric golgi complex 7. (854 aa)
	MAP11	Microtubule associated protein 11. (502 aa)
	W5Q8D6_SHEEP	Uncharacterized protein. (46 aa)
	VPS41	Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family. (854 aa)
	EXOC5	Exocyst complex component 5. (710 aa)
	VPS8	VPS8 subunit of CORVET complex. (1332 aa)
	VPS39	VPS39 subunit of HOPS complex. (876 aa)
	VPS18	VPS18 core subunit of CORVET and HOPS complexes. (752 aa)
	VPS54	VPS54 subunit of GARP complex. (979 aa)
	TRAPPC3	Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi. (180 aa)
	TRAPPC1	Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family. (145 aa)
	ZW10	Zw10 kinetochore protein. (782 aa)
	AKTIP	AKT interacting protein. (293 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKTIP	HOOK1	ENSOARP00000019156	ENSOARP00000009147	AKT interacting protein.	Hook microtubule tethering protein 1.	0.949
AKTIP	HOOK2	ENSOARP00000019156	ENSOARP00000011771	AKT interacting protein.	Hook microtubule tethering protein 2.	0.947
AKTIP	HOOK3	ENSOARP00000019156	ENSOARP00000003836	AKT interacting protein.	Hook microtubule tethering protein 3.	0.961
AKTIP	VPS18	ENSOARP00000019156	ENSOARP00000021803	AKT interacting protein.	VPS18 core subunit of CORVET and HOPS complexes.	0.464
CDC42	COG1	ENSOARP00000008675	ENSOARP00000014696	Cell division cycle 42.	Component of oligomeric golgi complex 1.	0.453
CDC42	COG2	ENSOARP00000008675	ENSOARP00000003302	Cell division cycle 42.	Component of oligomeric golgi complex 2.	0.433
CDC42	COG3	ENSOARP00000008675	ENSOARP00000008230	Cell division cycle 42.	Component of oligomeric golgi complex 3.	0.474
CDC42	COG5	ENSOARP00000008675	ENSOARP00000005717	Cell division cycle 42.	Component of oligomeric golgi complex 5.	0.454
CDC42	COG6	ENSOARP00000008675	ENSOARP00000010278	Cell division cycle 42.	Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.	0.493
CDC42	COG7	ENSOARP00000008675	ENSOARP00000018097	Cell division cycle 42.	Component of oligomeric golgi complex 7.	0.433
CDC42	COG8	ENSOARP00000008675	ENSOARP00000003781	Cell division cycle 42.	Conserved oligomeric Golgi complex subunit 8; Belongs to the COG8 family.	0.478
CDC42	EXOC1	ENSOARP00000008675	ENSOARP00000002516	Cell division cycle 42.	Exocyst complex component 1.	0.650
CDC42	EXOC3	ENSOARP00000008675	ENSOARP00000016954	Cell division cycle 42.	Exocyst complex component 3.	0.442
CDC42	EXOC5	ENSOARP00000008675	ENSOARP00000022678	Cell division cycle 42.	Exocyst complex component 5.	0.464
CDC42	EXOC6	ENSOARP00000008675	ENSOARP00000001058	Cell division cycle 42.	Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	0.416
CDC42	EXOC7	ENSOARP00000008675	ENSOARP00000008580	Cell division cycle 42.	Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.	0.608
CDC42	SH3BP1	ENSOARP00000008675	ENSOARP00000014953	Cell division cycle 42.	Uncharacterized protein.	0.405
COG1	CDC42	ENSOARP00000014696	ENSOARP00000008675	Component of oligomeric golgi complex 1.	Cell division cycle 42.	0.453
COG1	COG2	ENSOARP00000014696	ENSOARP00000003302	Component of oligomeric golgi complex 1.	Component of oligomeric golgi complex 2.	0.998
COG1	COG3	ENSOARP00000014696	ENSOARP00000008230	Component of oligomeric golgi complex 1.	Component of oligomeric golgi complex 3.	0.999