STRINGSTRING
MAPK7 MAPK7 PAK3 PAK3 RIOK1 RIOK1 HASPIN HASPIN ANKK1 ANKK1 STK25 STK25 PRKCB PRKCB CDK13 CDK13 PCK1 PCK1 PLK1 PLK1 NLK NLK CSNK1D CSNK1D MAPK15 MAPK15 MAP3K12 MAP3K12 MAP3K11 MAP3K11 ROCK2 ROCK2 MASTL MASTL CAMK2B CAMK2B PLK4 PLK4 PRKCA PRKCA RAF1 RAF1 MAPK1 MAPK1 RPS6KA3 RPS6KA3 MAP3K8 MAP3K8 STK33 STK33 W5PZF6_SHEEP W5PZF6_SHEEP W5PZE0_SHEEP W5PZE0_SHEEP SGK1 SGK1 RPS6KB1 RPS6KB1 PIM1 PIM1 CDK10 CDK10 NEK10 NEK10 MAP2K6 MAP2K6 PRKACB PRKACB PRKG1 PRKG1 STK38 STK38 PRKCQ PRKCQ MAPK13 MAPK13 PSKH2 PSKH2 MAPK14 MAPK14 MAP3K7 MAP3K7 RPS6KB2 RPS6KB2 CDK9 CDK9 MELK MELK PIM2 PIM2 CDK12 CDK12 RIPK2 RIPK2 W5PN72_SHEEP W5PN72_SHEEP PRKD2 PRKD2 CDK2 CDK2 TMEM248 TMEM248 DCLK1 DCLK1 PAK5 PAK5 LIMK2 LIMK2 MAP4K2 MAP4K2 PINK1 PINK1 ROCK1 ROCK1 MAPKAPK3 MAPKAPK3 CAMK2G CAMK2G MAP4K3 MAP4K3 RIOK3 RIOK3 W5PDG6_SHEEP W5PDG6_SHEEP PRKAA2 PRKAA2 W5PD66_SHEEP W5PD66_SHEEP RPS6KA4 RPS6KA4 PIK3CB PIK3CB PAK1 PAK1 PLK2 PLK2 AKT2 AKT2 PRKACA PRKACA MAP3K10 MAP3K10 TTBK1 TTBK1 AKT3 AKT3 PAK4 PAK4 IRAK1 IRAK1 PRKCE PRKCE MAP4K1 MAP4K1 W5P6K5_SHEEP W5P6K5_SHEEP PKN1 PKN1 CSNK1A1 CSNK1A1 CDK4 CDK4 PRKD1 PRKD1 RPS6KA2 RPS6KA2 PIK3CG PIK3CG W5P3V9_SHEEP W5P3V9_SHEEP STK4 STK4 RPS6KA1 RPS6KA1 CDK1 CDK1 W5P1W6_SHEEP W5P1W6_SHEEP W5P1S2_SHEEP W5P1S2_SHEEP MAPK10 MAPK10 STK10 STK10 MAPK3 MAPK3 RPS6KA5 RPS6KA5 DSTYK DSTYK CLK3 CLK3 MAP3K21 MAP3K21 IKBKB IKBKB PSKH1 PSKH1 MTOR MTOR CDK5 CDK5 MKNK1 MKNK1 W5NWY2_SHEEP W5NWY2_SHEEP CDC42BPA CDC42BPA RPS6KA6 RPS6KA6 MAPK9 MAPK9 TESK2 TESK2 MAPK8 MAPK8 CSNK2A2 CSNK2A2 SBK3 SBK3 SBK1 SBK1 PRKCG PRKCG CIT CIT PRPF4B PRPF4B PRKCZ PRKCZ PRKCI PRKCI PRKCD PRKCD VRK1 VRK1 MAP3K9 MAP3K9 PRKCH PRKCH DAPK2 DAPK2 CSNK1G1 CSNK1G1 PIK3CA PIK3CA MAP4K5 MAP4K5 MAP3K13 MAP3K13 PAK2 PAK2 TNK2 TNK2 GSK3B GSK3B MAPK12 MAPK12 AAK1 AAK1 STK40 STK40 IRAK4 IRAK4 PIM3 PIM3 W5QE29_SHEEP W5QE29_SHEEP PRKG2 PRKG2 CSNK2A1 CSNK2A1 AURKB AURKB CAMK2D CAMK2D AURKA AURKA CCDC151 CCDC151
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK7Mitogen-activated protein kinase. (774 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
RIOK1Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (568 aa)
HASPINHistone H3 associated protein kinase. (721 aa)
ANKK1Ankyrin repeat and kinase domain containing 1. (660 aa)
STK25Serine/threonine kinase 25. (430 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (576 aa)
CDK13Cyclin dependent kinase 13. (1108 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (620 aa)
PLK1Serine/threonine-protein kinase PLK. (605 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (544 aa)
CSNK1DCasein kinase 1 delta. (403 aa)
MAPK15Protein kinase domain-containing protein. (247 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (894 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (858 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1355 aa)
MASTLMicrotubule associated serine/threonine kinase like. (883 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (664 aa)
PLK4Polo like kinase 4. (896 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (631 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
MAPK1Mitogen-activated protein kinase. (320 aa)
RPS6KA3Non-specific serine/threonine protein kinase. (712 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (475 aa)
STK33Serine/threonine kinase 33. (518 aa)
W5PZF6_SHEEPPKcGMP_CC domain-containing protein. (82 aa)
W5PZE0_SHEEPUncharacterized protein. (85 aa)
SGK1Non-specific serine/threonine protein kinase. (432 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (478 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (355 aa)
CDK10Cyclin dependent kinase 10; Belongs to the protein kinase superfamily. (360 aa)
NEK10NIMA related kinase 10. (1116 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
PRKG1Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (471 aa)
STK38Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (466 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
MAPK13Mitogen-activated protein kinase. (326 aa)
PSKH2Protein serine kinase H2. (368 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
CDK9Cyclin dependent kinase 9. (341 aa)
MELKNon-specific serine/threonine protein kinase. (650 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (371 aa)
CDK12Cyclin dependent kinase 12. (1481 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
W5PN72_SHEEPProtein kinase domain-containing protein. (345 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (868 aa)
CDK2Protein kinase domain-containing protein. (298 aa)
TMEM248Transmembrane protein 248. (317 aa)
DCLK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
LIMK2LIM domain kinase 2. (639 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (789 aa)
PINK1PTEN induced kinase 1. (589 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1372 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (384 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (547 aa)
MAP4K3Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (831 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
W5PDG6_SHEEPUncharacterized protein. (705 aa)
PRKAA2Non-specific serine/threonine protein kinase. (546 aa)
W5PD66_SHEEPAGC-kinase C-terminal domain-containing protein. (403 aa)
RPS6KA4Ribosomal protein S6 kinase. (734 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PLK2Serine/threonine-protein kinase PLK. (685 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (455 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (349 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase 10. (833 aa)
TTBK1Tau tubulin kinase 1. (1229 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PAK4P21 (RAC1) activated kinase 4. (559 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (652 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (836 aa)
W5P6K5_SHEEPUncharacterized protein. (64 aa)
PKN1Protein kinase N1. (881 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (337 aa)
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (345 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (833 aa)
RPS6KA2Ribosomal protein S6 kinase. (736 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1125 aa)
W5P3V9_SHEEPProtein kinase domain-containing protein. (185 aa)
STK4Serine/threonine kinase 4. (488 aa)
RPS6KA1Ribosomal protein S6 kinase. (743 aa)
CDK1Cell division cycle 2 protein isoform 1; Belongs to the protein kinase superfamily. (297 aa)
W5P1W6_SHEEPProtein kinase domain-containing protein. (208 aa)
W5P1S2_SHEEPClaudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa)
MAPK10Mitogen-activated protein kinase. (426 aa)
STK10Serine/threonine kinase 10. (1035 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (372 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (908 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (840 aa)
CLK3CDC like kinase 3. (524 aa)
MAP3K21Mitogen-activated protein kinase kinase kinase 21. (855 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (758 aa)
PSKH1Protein serine kinase H1; Belongs to the protein kinase superfamily. (424 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (433 aa)
W5NWY2_SHEEPProtein kinase domain-containing protein. (264 aa)
CDC42BPANon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1749 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (711 aa)
MAPK9Mitogen-activated protein kinase. (425 aa)
TESK2Testis associated actin remodelling kinase 2. (562 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (315 aa)
SBK3SH3 domain binding kinase family member 3. (351 aa)
SBK1SH3 domain binding kinase 1. (376 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (640 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2067 aa)
PRPF4BPre-mRNA processing factor 4B. (1040 aa)
PRKCZUncharacterized protein; Belongs to the protein kinase superfamily. (478 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (630 aa)
PRKCDProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (396 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase. (938 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
DAPK2Death associated protein kinase 2. (336 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (457 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)
MAP4K5Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (865 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (973 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
TNK2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (563 aa)
GSK3BProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (433 aa)
MAPK12Mitogen-activated protein kinase. (263 aa)
AAK1AP2 associated kinase 1. (960 aa)
STK40Serine/threonine kinase 40. (436 aa)
IRAK4Protein kinase domain-containing protein. (460 aa)
PIM3Protein kinase domain-containing protein. (117 aa)
W5QE29_SHEEPBMP2K_C domain-containing protein. (351 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (392 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (406 aa)
CAMK2DProtein kinase domain-containing protein. (533 aa)
AURKAProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (405 aa)
CCDC151Coiled-coil domain containing 151. (622 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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