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| | MPST | Sulfurtransferase. (318 aa) |
| | W5PBI3_SHEEP | AIRS_C domain-containing protein. (373 aa) |
| | W5PBR3_SHEEP | ANK_REP_REGION domain-containing protein. (487 aa) |
| | SDS | Serine dehydratase. (329 aa) |
| | ASS1 | Argininosuccinate synthase 1. (410 aa) |
| | MRI1 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (363 aa) |
| | W5PEN6_SHEEP | Uncharacterized protein. (551 aa) |
| | W5PEQ8_SHEEP | Uncharacterized protein. (117 aa) |
| | HSD17B10 | Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (471 aa) |
| | GLS2 | Glutaminase 2. (602 aa) |
| | W5PHB0_SHEEP | Aminotran_1_2 domain-containing protein. (428 aa) |
| | HAAO | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (300 aa) |
| | SDSL | Serine dehydratase like. (329 aa) |
| | SHMT2 | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa) |
| | W5PB69_SHEEP | ANK_REP_REGION domain-containing protein. (204 aa) |
| | ASPG | Asparaginase_C domain-containing protein. (74 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (588 aa) |
| | HMGCL | 3-hydroxy-3-methylglutaryl-CoA lyase. (325 aa) |
| | TDO2 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa) |
| | ALDH5A1 | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (447 aa) |
| | NAGS | N-acetylglutamate synthase. (525 aa) |
| | HMGCLL1 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (266 aa) |
| | PCBD1 | Pterin-4 alpha-carbinolamine dehydratase 1. (185 aa) |
| | ALDH18A1 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa) |
| | W5P8I4_SHEEP | Uncharacterized protein. (400 aa) |
| | SEPHS1 | Selenophosphate synthetase 1. (392 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (482 aa) |
| | PLOD2 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (841 aa) |
| | ADSS2 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (458 aa) |
| | PIPOX | Pipecolic acid and sarcosine oxidase. (393 aa) |
| | DDAH2 | Dimethylarginine dimethylaminohydrolase 2. (286 aa) |
| | AFMID | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa) |
| | W5P5R4_SHEEP | Beta_elim_lyase domain-containing protein. (383 aa) |
| | ADI1 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (139 aa) |
| | MCCC2 | Methylcrotonoyl-CoA carboxylase 2. (563 aa) |
| | THAP8 | THAP domain containing 8. (273 aa) |
| | PRODH2 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (469 aa) |
| | GAD2 | Glutamate decarboxylase 2. (578 aa) |
| | ASNS | Asparagine synthetase [glutamine-hydrolyzing]. (561 aa) |
| | GNMT | Glycine N-methyltransferase. (308 aa) |
| | ILVBL | IlvB acetolactate synthase like; Belongs to the TPP enzyme family. (635 aa) |
| | HNF4A | Uncharacterized protein. (476 aa) |
| | TAT | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (456 aa) |
| | NOX4 | NADPH oxidase 4. (594 aa) |
| | MTR | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1268 aa) |
| | THNSL1 | Threonine synthase like 1. (715 aa) |
| | THAP5 | THAP domain containing 5. (395 aa) |
| | TH | Tyrosine hydroxylase. (441 aa) |
| | GMPS | Guanine monophosphate synthase. (705 aa) |
| | SARDH | Sarcosine dehydrogenase. (904 aa) |
| | IYD | Iodotyrosine deiodinase. (290 aa) |
| | AGXT-2 | Aminotran_5 domain-containing protein. (108 aa) |
| | AASDHPPT | Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa) |
| | NOXRED1 | NADP dependent oxidoreductase domain containing 1. (349 aa) |
| | TMED8 | Transmembrane p24 trafficking protein family member 8. (288 aa) |
| | GSTZ1 | Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (240 aa) |
| | GPT | Glutamic--pyruvic transaminase. (535 aa) |
| | GAD1 | Glutamate decarboxylase 1. (599 aa) |
| | IDO2 | Indoleamine 2,3-dioxygenase 2. (407 aa) |
| | W5NW74_SHEEP | Uncharacterized protein. (94 aa) |
| | IDO1 | Indoleamine-pyrrole 2,3 dioxygenase. (410 aa) |
| | W5NW12_SHEEP | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (491 aa) |
| | NOS3 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa) |
| | RIMKLB | Ribosomal modification protein rimK like family member B. (393 aa) |
| | GOT2 | Aspartate aminotransferase. (430 aa) |
| | DLST | Dihydrolipoamide S-succinyltransferase. (455 aa) |
| | LOC101107259 | Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (425 aa) |
| | GFPT2 | Glutamine-fructose-6-phosphate transaminase 2. (784 aa) |
| | W5NTG3_SHEEP | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (175 aa) |
| | GOT1L1 | Glutamic-oxaloacetic transaminase 1 like 1. (461 aa) |
| | ALDH6A1 | Aldehyde dehydrogenase 6 family member A1. (536 aa) |
| | ENOPH1 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (262 aa) |
| | GLUD1 | Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (522 aa) |
| | ASL | Uncharacterized protein. (468 aa) |
| | OTC | Ornithine carbamoyltransferase, mitochondrial. (355 aa) |
| | DCT | Uncharacterized protein. (551 aa) |
| | W5NQD4_SHEEP | Glutamine amidotransferase type-1 domain-containing protein. (619 aa) |
| | PFAS | Uncharacterized protein. (748 aa) |
| | ACADSB | Acyl-CoA dehydrogenase short/branched chain. (434 aa) |
| | HIBADH | Uncharacterized protein. (330 aa) |
| | AGMAT | Agmatinase; Belongs to the arginase family. (361 aa) |
| | PSPH | Uncharacterized protein. (231 aa) |
| | KYNU | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (463 aa) |
| | DDO | D-aspartate oxidase. (360 aa) |
| | OAT | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa) |
| | TTC36 | Tetratricopeptide repeat domain 36. (190 aa) |
| | GCDH | Glutaryl-CoA dehydrogenase. (439 aa) |
| | MAT1A | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (399 aa) |
| | QDPR | Quinoid dihydropteridine reductase. (224 aa) |
| | BLMH | Bleomycin hydrolase; Belongs to the peptidase C1 family. (459 aa) |
| | ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (611 aa) |
| | W5PMC4_SHEEP | Uncharacterized protein. (452 aa) |
| | HOGA1 | 4-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa) |
| | PADI3 | Protein-arginine deiminase type-3; Catalyzes the deimination of arginine residues of proteins. (452 aa) |
| | ACAT1 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa) |
| | CBS | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa) |
| | W5PNL2_SHEEP | Uncharacterized protein. (284 aa) |
| | GLYAT | Uncharacterized protein. (298 aa) |
| | AGXT2 | Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa) |
| | FPGS | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (585 aa) |
| | DGLUCY | D-glutamate cyclase. (567 aa) |
| | SIRT4 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (370 aa) |
| | CTH | Cystathionine gamma-lyase. (417 aa) |
| | AMDHD1 | Amidohydrolase domain containing 1. (426 aa) |
| | MMUT | Methylmalonyl-CoA mutase. (755 aa) |
| | HAL | Histidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa) |
| | BCAT2 | Branched chain amino acid transaminase 2. (396 aa) |
| | W5PRP2_SHEEP | P5CR_dimer domain-containing protein. (240 aa) |
| | PSAT1 | Phosphoserine aminotransferase. (396 aa) |
| | GOT1 | Aspartate aminotransferase. (413 aa) |
| | HPD | 4-hydroxyphenylpyruvate dioxygenase. (393 aa) |
| | W5PTP1_SHEEP | Amino_oxidase domain-containing protein. (265 aa) |
| | CTPS2 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa) |
| | FTCD | Formimidoyltransferase cyclodeaminase. (540 aa) |
| | SLC39A8 | Solute carrier family 39 member 8. (461 aa) |
| | ACAD8 | Acyl-CoA dehydrogenase family member 8. (402 aa) |
| | GLDC | Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1025 aa) |
| | IL4I1 | Interleukin 4 induced 1. (501 aa) |
| | AMT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (374 aa) |
| | GLS | Glutaminase. (634 aa) |
| | W5PWM0_SHEEP | Uncharacterized protein. (503 aa) |
| | ARG1 | Arginase. (352 aa) |
| | DPEP1 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity. In lung tissue, it may terminate or significantly reduce the leukotriene induced signal for bronchospasm. (499 aa) |
| | GCAT | Glycine C-acetyltransferase. (430 aa) |
| | DDAH1 | Dimethylarginine dimethylaminohydrolase 1. (337 aa) |
| | MTAP | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (283 aa) |
| | MTRR | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (723 aa) |
| | ALDH8A1 | Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa) |
| | DHFR | DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa) |
| | ASRGL1 | Asparaginase and isoaspartyl peptidase 1. (312 aa) |
| | KYAT3 | Kynurenine aminotransferase 3. (457 aa) |
| | PLOD3 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (755 aa) |
| | W5Q0R2_SHEEP | Epimerase domain-containing protein. (373 aa) |
| | FAH | Fumarylacetoacetase. (433 aa) |
| | SRR | Serine racemase. (339 aa) |
| | ODC1 | Ornithine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa) |
| | W5Q1I4_SHEEP | Aminotran_1_2 domain-containing protein. (269 aa) |
| | GPT2 | Glutamic--pyruvic transaminase 2. (523 aa) |
| | FTCDNL1 | FTCD_N domain-containing protein. (328 aa) |
| | PAH | Phenylalanine hydroxylase. (451 aa) |
| | HIBCH | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa) |
| | ASNSD1 | Glutamine amidotransferase type-2 domain-containing protein. (644 aa) |
| | CDO1 | Cysteine dioxygenase. (147 aa) |
| | PYCR3 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (281 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa) |
| | ATF4 | BZIP domain-containing protein. (353 aa) |
| | AZIN1 | Antizyme inhibitor 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa) |
| | GCLM | Glutamate-cysteine ligase modifier subunit. (272 aa) |
| | BHMT2 | Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (360 aa) |
| | BHMT | Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (407 aa) |
| | DAO | D-amino acid oxidase. (351 aa) |
| | ADHFE1 | Fe-ADH domain-containing protein. (449 aa) |
| | THAP4 | THAP domain containing 4. (553 aa) |
| | PYCR1 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (320 aa) |
| | PYCR2 | Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family. (319 aa) |
| | NIT2 | Nitrilase family member 2. (283 aa) |
| | AGXT | Serine--pyruvate aminotransferase. (401 aa) |
| | MTHFR | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (701 aa) |
| | SHMT1 | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (486 aa) |
| | AASS | Aminoadipate-semialdehyde synthase. (926 aa) |
| | APIP | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (242 aa) |
| | GLUL | Glutamine synthetase. (373 aa) |
| | SCLY | Selenocysteine lyase. (447 aa) |
| | TST | Sulfurtransferase. (297 aa) |
| | CPS1 | Carbamoyl-phosphate synthase 1. (1500 aa) |
| | CAD | Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2223 aa) |
| | GFPT1 | Glutamine--fructose-6-phosphate transaminase 1. (603 aa) |
| | HGD | Homogentisate 1,2-dioxygenase. (445 aa) |
| | IVD | Isovaleryl-CoA dehydrogenase. (429 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (610 aa) |
| | RIMKLA | Ribosomal modification protein rimK like family member A. (393 aa) |
| | PHGDH | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (535 aa) |
| | W5QH04_SHEEP | Amine oxidase. (518 aa) |
| | THNSL2 | Threonine synthase like 2. (485 aa) |
| | AZIN2 | Antizyme inhibitor 2; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (519 aa) |
| | MTHFD1 | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (977 aa) |
| | ARG2 | Arginase. (354 aa) |
