STRINGSTRING
GOT2 GOT2 DLST DLST W5NTG3_SHEEP W5NTG3_SHEEP ALDH6A1 ALDH6A1 GLUD1 GLUD1 OTC OTC MAT1A MAT1A QDPR QDPR BLMH BLMH ALDH4A1 ALDH4A1 HOGA1 HOGA1 PADI3 PADI3 ACAT1 ACAT1 CBS CBS W5PNL2_SHEEP W5PNL2_SHEEP AGXT2 AGXT2 BCAT2 BCAT2 GOT1 GOT1 HPD HPD ACADSB ACADSB GLS2 GLS2 KMO KMO HSD17B10 HSD17B10 W5PEQ8_SHEEP W5PEQ8_SHEEP SDS SDS HAAO HAAO ARG2 ARG2 THNSL2 THNSL2 W5QH04_SHEEP W5QH04_SHEEP IVD IVD HGD HGD SDSL SDSL SHMT2 SHMT2 HMGCL HMGCL TDO2 TDO2 HMGCLL1 HMGCLL1 PIPOX PIPOX DDAH2 DDAH2 AFMID AFMID W5P5R4_SHEEP W5P5R4_SHEEP MCCC2 MCCC2 PRODH2 PRODH2 GAD2 GAD2 TAT TAT THNSL1 THNSL1 SARDH SARDH AGXT-2 AGXT-2 GSTZ1 GSTZ1 GPT GPT GAD1 GAD1 IDO2 IDO2 W5NW74_SHEEP W5NW74_SHEEP IDO1 IDO1 W5PTP1_SHEEP W5PTP1_SHEEP ACAD8 ACAD8 GLDC GLDC IL4I1 IL4I1 AMT AMT GLS GLS ARG1 ARG1 GCAT GCAT DDAH1 DDAH1 MTRR MTRR ALDH8A1 ALDH8A1 ASRGL1 ASRGL1 KYAT3 KYAT3 W5Q0R2_SHEEP W5Q0R2_SHEEP FAH FAH W5Q1I4_SHEEP W5Q1I4_SHEEP GPT2 GPT2 SCLY SCLY PAH PAH HIBCH HIBCH CDO1 CDO1 NOS2 NOS2 DAO DAO ADHFE1 ADHFE1 AGXT AGXT SHMT1 SHMT1 AASS AASS HIBADH HIBADH KYNU KYNU DDO DDO OAT OAT W5NW12_SHEEP W5NW12_SHEEP NOS3 NOS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GOT2Aspartate aminotransferase. (430 aa)
DLSTDihydrolipoamide S-succinyltransferase. (455 aa)
W5NTG3_SHEEPGlycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (175 aa)
ALDH6A1Aldehyde dehydrogenase 6 family member A1. (536 aa)
GLUD1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (522 aa)
OTCOrnithine carbamoyltransferase, mitochondrial. (355 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (399 aa)
QDPRQuinoid dihydropteridine reductase. (224 aa)
BLMHBleomycin hydrolase; Belongs to the peptidase C1 family. (459 aa)
ALDH4A1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (611 aa)
HOGA14-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (327 aa)
PADI3Protein-arginine deiminase type-3; Catalyzes the deimination of arginine residues of proteins. (452 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (427 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa)
W5PNL2_SHEEPUncharacterized protein. (284 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
BCAT2Branched chain amino acid transaminase 2. (396 aa)
GOT1Aspartate aminotransferase. (413 aa)
HPD4-hydroxyphenylpyruvate dioxygenase. (393 aa)
ACADSBAcyl-CoA dehydrogenase short/branched chain. (434 aa)
GLS2Glutaminase 2. (602 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (471 aa)
HSD17B10Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
W5PEQ8_SHEEPUncharacterized protein. (117 aa)
SDSSerine dehydratase. (329 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (300 aa)
ARG2Arginase. (354 aa)
THNSL2Threonine synthase like 2. (485 aa)
W5QH04_SHEEPAmine oxidase. (518 aa)
IVDIsovaleryl-CoA dehydrogenase. (429 aa)
HGDHomogentisate 1,2-dioxygenase. (445 aa)
SDSLSerine dehydratase like. (329 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa)
HMGCL3-hydroxy-3-methylglutaryl-CoA lyase. (325 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
HMGCLL13-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. (266 aa)
PIPOXPipecolic acid and sarcosine oxidase. (393 aa)
DDAH2Dimethylarginine dimethylaminohydrolase 2. (286 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (307 aa)
W5P5R4_SHEEPBeta_elim_lyase domain-containing protein. (383 aa)
MCCC2Methylcrotonoyl-CoA carboxylase 2. (563 aa)
PRODH2Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (469 aa)
GAD2Glutamate decarboxylase 2. (578 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (456 aa)
THNSL1Threonine synthase like 1. (715 aa)
SARDHSarcosine dehydrogenase. (904 aa)
AGXT-2Aminotran_5 domain-containing protein. (108 aa)
GSTZ1Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (240 aa)
GPTGlutamic--pyruvic transaminase. (535 aa)
GAD1Glutamate decarboxylase 1. (599 aa)
IDO2Indoleamine 2,3-dioxygenase 2. (407 aa)
W5NW74_SHEEPUncharacterized protein. (94 aa)
IDO1Indoleamine-pyrrole 2,3 dioxygenase. (410 aa)
W5PTP1_SHEEPAmino_oxidase domain-containing protein. (265 aa)
ACAD8Acyl-CoA dehydrogenase family member 8. (402 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1025 aa)
IL4I1Interleukin 4 induced 1. (501 aa)
AMTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (374 aa)
GLSGlutaminase. (634 aa)
ARG1Arginase. (352 aa)
GCATGlycine C-acetyltransferase. (430 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (337 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (723 aa)
ALDH8A1Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa)
ASRGL1Asparaginase and isoaspartyl peptidase 1. (312 aa)
KYAT3Kynurenine aminotransferase 3. (457 aa)
W5Q0R2_SHEEPEpimerase domain-containing protein. (373 aa)
FAHFumarylacetoacetase. (433 aa)
W5Q1I4_SHEEPAminotran_1_2 domain-containing protein. (269 aa)
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
SCLYSelenocysteine lyase. (447 aa)
PAHPhenylalanine hydroxylase. (451 aa)
HIBCH3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (386 aa)
CDO1Cysteine dioxygenase. (147 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
DAOD-amino acid oxidase. (351 aa)
ADHFE1Fe-ADH domain-containing protein. (449 aa)
AGXTSerine--pyruvate aminotransferase. (401 aa)
SHMT1Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (486 aa)
AASSAminoadipate-semialdehyde synthase. (926 aa)
HIBADHUncharacterized protein. (330 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (463 aa)
DDOD-aspartate oxidase. (360 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
W5NW12_SHEEPProline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (491 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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