19 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBX5	T-box transcription factor 5. (504 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
	SOX6	SRY-box transcription factor 6. (828 aa)
	W5P4X8_SHEEP	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (615 aa)
	SMAD4	Mothers against decapentaplegic homolog. (553 aa)
	DHX36	DEAH-box helicase 36. (1065 aa)
	BMP4	TGF_BETA_2 domain-containing protein. (409 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (508 aa)
	SOX17	SRY-box transcription factor 17. (267 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (834 aa)
	BMP2	Bone morphogenetic protein 2. (425 aa)
	GPER1	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (168 aa)
	FZD7	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (511 aa)
	MEF2C	MADS-box domain-containing protein. (463 aa)
	MYOCD	Myocardin. (980 aa)
	EGFR	Receptor protein-tyrosine kinase. (1155 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
	GATA6	GATA binding protein 6. (613 aa)
	ARRB2	Arrestin beta 2. (409 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB2	EGFR	ENSOARP00000008370	ENSOARP00000014758	Arrestin beta 2.	Receptor protein-tyrosine kinase.	0.441
BMP2	BMP4	ENSOARP00000020124	ENSOARP00000022643	Bone morphogenetic protein 2.	TGF_BETA_2 domain-containing protein.	0.931
BMP2	SMAD4	ENSOARP00000020124	ENSOARP00000004992	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.857
BMP2	TGFB2	ENSOARP00000020124	ENSOARP00000012419	Bone morphogenetic protein 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.473
BMP2	WNT3A	ENSOARP00000020124	ENSOARP00000007005	Bone morphogenetic protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.491
BMP4	BMP2	ENSOARP00000022643	ENSOARP00000020124	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 2.	0.931
BMP4	GATA6	ENSOARP00000022643	ENSOARP00000008867	TGF_BETA_2 domain-containing protein.	GATA binding protein 6.	0.674
BMP4	MEF2C	ENSOARP00000022643	ENSOARP00000017290	TGF_BETA_2 domain-containing protein.	MADS-box domain-containing protein.	0.438
BMP4	SMAD4	ENSOARP00000022643	ENSOARP00000004992	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.914
BMP4	SOX17	ENSOARP00000022643	ENSOARP00000021663	TGF_BETA_2 domain-containing protein.	SRY-box transcription factor 17.	0.832
BMP4	TBX5	ENSOARP00000022643	ENSOARP00000007082	TGF_BETA_2 domain-containing protein.	T-box transcription factor 5.	0.605
BMP4	WNT3A	ENSOARP00000022643	ENSOARP00000007005	TGF_BETA_2 domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.769
EGFR	ARRB2	ENSOARP00000014758	ENSOARP00000008370	Receptor protein-tyrosine kinase.	Arrestin beta 2.	0.441
EGFR	SMAD4	ENSOARP00000014758	ENSOARP00000004992	Receptor protein-tyrosine kinase.	Mothers against decapentaplegic homolog.	0.672
EGFR	TGFB2	ENSOARP00000014758	ENSOARP00000012419	Receptor protein-tyrosine kinase.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.457
EGFR	WNT3A	ENSOARP00000014758	ENSOARP00000007005	Receptor protein-tyrosine kinase.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.415
FZD7	PRICKLE1	ENSOARP00000018819	ENSOARP00000021200	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Prickle planar cell polarity protein 1.	0.423
FZD7	WNT3A	ENSOARP00000018819	ENSOARP00000007005	Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.743
GATA6	BMP4	ENSOARP00000008867	ENSOARP00000022643	GATA binding protein 6.	TGF_BETA_2 domain-containing protein.	0.674
GATA6	MEF2C	ENSOARP00000008867	ENSOARP00000017290	GATA binding protein 6.	MADS-box domain-containing protein.	0.538