STRINGSTRING
LGALS3 LGALS3 C2CD5 C2CD5 CHP1 CHP1 PDPK1 PDPK1 RER1 RER1 TCAF1 TCAF1 W5Q9Y6_SHEEP W5Q9Y6_SHEEP GPER1 GPER1 SLC51B SLC51B ITGB1 ITGB1 CNPY4 CNPY4 EPHA3 EPHA3 ARHGEF16 ARHGEF16 MIEF1 MIEF1 STAC STAC W5Q3M4_SHEEP W5Q3M4_SHEEP W5Q3L8_SHEEP W5Q3L8_SHEEP MESD MESD CEMIP CEMIP ITGB1BP1 ITGB1BP1 FIS1 FIS1 EGFR EGFR RAMP3 RAMP3 KIF5B KIF5B KCNB1 KCNB1 MYO1C MYO1C EPHA2 EPHA2 STX3 STX3 CIB1 CIB1 W5PR06_SHEEP W5PR06_SHEEP DPP10 DPP10 ERBB2 ERBB2 R3HDM1 R3HDM1 STAC2 STAC2 ZDHHC5 ZDHHC5 ANXA13 ANXA13 EFCAB7 EFCAB7 FYN FYN ATP2C1 ATP2C1 W5PH02_SHEEP W5PH02_SHEEP TNFAIP6 TNFAIP6 AGR2 AGR2 ATP2B4 ATP2B4 TNF TNF W5PD66_SHEEP W5PD66_SHEEP TGFB1 TGFB1 LRP1 LRP1 GNB2L1 GNB2L1 STAC3 STAC3 R3HDM2 R3HDM2 WNK3 WNK3 WNT3A WNT3A AKT2 AKT2 PLS1 PLS1 W5P7A5_SHEEP W5P7A5_SHEEP PIK3R1 PIK3R1 W5P784_SHEEP W5P784_SHEEP ITGA3 ITGA3 CLIP3 CLIP3 DLG2 DLG2 PRKN PRKN W5P3W8_SHEEP W5P3W8_SHEEP LRP4 LRP4 W5P2V0_SHEEP W5P2V0_SHEEP PDCD5 PDCD5 CNST CNST CDK5R1 CDK5R1 SPTBN1 SPTBN1 CD81 CD81 CLN3 CLN3 W5NYC3_SHEEP W5NYC3_SHEEP EZR EZR SQSTM1 SQSTM1 CDK5 CDK5 W5NVU9_SHEEP W5NVU9_SHEEP W5NVT1_SHEEP W5NVT1_SHEEP W5NUL6_SHEEP W5NUL6_SHEEP TREM2 TREM2 AKAP5 AKAP5 ARF6 ARF6 RANGRF RANGRF PRKCI PRKCI MIEF2 MIEF2 ACSL3 ACSL3 DLG1 DLG1 SPTBN5 SPTBN5 VIL1 VIL1 MFF MFF PDZK1 PDZK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LGALS3Galectin. (249 aa)
C2CD5C2 calcium dependent domain containing 5. (1126 aa)
CHP1Calcineurin like EF-hand protein 1. (211 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (559 aa)
RER1Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment. (196 aa)
TCAF1TRPM8 channel associated factor 1. (1030 aa)
W5Q9Y6_SHEEPPeptidase M60 domain-containing protein. (761 aa)
GPER1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (168 aa)
SLC51BSolute carrier family 51 beta subunit. (130 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
CNPY4Canopy FGF signaling regulator 4. (251 aa)
EPHA3EPH receptor A3. (984 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (707 aa)
MIEF1Mitochondrial elongation factor 1. (459 aa)
STACSH3 and cysteine rich domain. (405 aa)
W5Q3M4_SHEEPUncharacterized protein. (96 aa)
W5Q3L8_SHEEPUncharacterized protein. (368 aa)
MESDMesoderm development LRP chaperone. (232 aa)
CEMIPCell migration inducing hyaluronidase 1. (1361 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (204 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (151 aa)
EGFRReceptor protein-tyrosine kinase. (1155 aa)
RAMP3Receptor activity modifying protein 3. (144 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (964 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1067 aa)
EPHA2EPH receptor A2. (993 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (236 aa)
CIB1Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] (217 aa)
W5PR06_SHEEPWD_REPEATS_REGION domain-containing protein. (266 aa)
DPP10Dipeptidyl peptidase like 10; Belongs to the peptidase S9B family. (789 aa)
ERBB2Receptor protein-tyrosine kinase. (1251 aa)
R3HDM1R3H domain containing 1. (1095 aa)
STAC2SH3 and cysteine rich domain 2. (406 aa)
ZDHHC5Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (687 aa)
ANXA13Annexin. (283 aa)
EFCAB7EF-hand calcium binding domain 7. (629 aa)
FYNTyrosine-protein kinase. (537 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (921 aa)
W5PH02_SHEEPCation_ATPase_N domain-containing protein. (245 aa)
TNFAIP6TNF alpha induced protein 6. (280 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (179 aa)
ATP2B4Uncharacterized protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (478 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
W5PD66_SHEEPAGC-kinase C-terminal domain-containing protein. (403 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
LRP1LDL receptor related protein 1. (4526 aa)
GNB2L1Guanine nucleotide-binding protein beta polypeptide 2-like 1. (317 aa)
STAC3SH3 and cysteine rich domain 3. (362 aa)
R3HDM2Uncharacterized protein. (991 aa)
WNK3WNK lysine deficient protein kinase 3. (2497 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (455 aa)
PLS1Plastin 1. (635 aa)
W5P7A5_SHEEPUncharacterized protein. (125 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (725 aa)
W5P784_SHEEPUncharacterized protein. (191 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1039 aa)
CLIP3CAP-Gly domain containing linker protein 3. (546 aa)
DLG2Discs large MAGUK scaffold protein 2. (905 aa)
PRKNUbiquitin-like domain-containing protein. (371 aa)
W5P3W8_SHEEPRBR-type E3 ubiquitin transferase. (80 aa)
LRP4LDL receptor related protein 4. (1911 aa)
W5P2V0_SHEEPFERM domain-containing protein. (551 aa)
PDCD5Uncharacterized protein. (125 aa)
CNSTConsortin, connexin sorting protein. (721 aa)
CDK5R1Cyclin dependent kinase 5 regulatory subunit 1. (300 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2363 aa)
CD81Tetraspanin. (236 aa)
CLN3Battenin. (438 aa)
W5NYC3_SHEEPUncharacterized protein. (189 aa)
EZRFERM domain-containing protein. (553 aa)
SQSTM1Uncharacterized protein. (445 aa)
CDK5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
W5NVU9_SHEEPUncharacterized protein. (147 aa)
W5NVT1_SHEEPCation_ATPase_C domain-containing protein. (188 aa)
W5NUL6_SHEEPCation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (369 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (234 aa)
AKAP5A-kinase anchoring protein 5. (423 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (630 aa)
MIEF2Mitochondrial elongation factor 2. (406 aa)
ACSL3Acyl-CoA synthetase long chain family member 3. (720 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (927 aa)
SPTBN5Spectrin beta, non-erythrocytic 5. (3632 aa)
VIL1Villin 1. (812 aa)
MFFMitochondrial fission factor. (353 aa)
PDZK1PDZ domain containing 1. (523 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: medium (70%) [HD]