STRINGSTRING
POU4F1 POU4F1 TRAF6 TRAF6 EP300 EP300 PAX6 PAX6 IGF1 IGF1 HAND2 HAND2 GTF2B GTF2B GATA3 GATA3 NIBAN2 NIBAN2 PARK7 PARK7 RB1 RB1 TGFB1 TGFB1 DDRGK1 DDRGK1 CTNNB1 CTNNB1 IFNG IFNG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POU4F1Uncharacterized protein. (114 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (542 aa)
EP300E1A binding protein p300. (2428 aa)
PAX6Paired box 6. (436 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (172 aa)
HAND2Heart and neural crest derivatives expressed 2. (129 aa)
GTF2BGeneral transcription factor IIB. (321 aa)
GATA3GATA binding protein 3. (322 aa)
NIBAN2Niban apoptosis regulator 2. (732 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
RB1RB transcriptional corepressor 1. (939 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
DDRGK1DDRGK domain containing 1. (323 aa)
CTNNB1Catenin beta 1. (782 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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