43 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MEI4	Meiotic double-stranded break formation protein 4. (395 aa)
	W5PBQ6_SHEEP	Uncharacterized protein. (171 aa)
	FAM43A	Family with sequence similarity 43 member A. (421 aa)
	C14orf39	Chromosome 14 open reading frame 39. (584 aa)
	SYCP1	Synaptonemal complex protein 1. (1000 aa)
	MLH3	MutL homolog 3. (1485 aa)
	CCNB1IP1	Cyclin B1 interacting protein 1. (277 aa)
	RNF212B	Ring finger protein 212B. (300 aa)
	REC8	REC8 meiotic recombination protein. (592 aa)
	REC114	REC114 meiotic recombination protein. (214 aa)
	RAD21L1	RAD21 cohesin complex component like 1. (554 aa)
	SNPH	Syntaphilin. (545 aa)
	FAM43B	Family with sequence similarity 43 member B. (176 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (395 aa)
	RRS1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (358 aa)
	RAD9B	Cell cycle checkpoint control protein; Belongs to the rad9 family. (429 aa)
	SMC3	Structural maintenance of chromosomes protein. (1217 aa)
	SYCE2	Synaptonemal complex central element protein 2. (184 aa)
	RAD21	RAD21 cohesin complex component. (630 aa)
	W5PL10_SHEEP	Uncharacterized protein. (376 aa)
	RAD9A	Cell cycle checkpoint control protein; Belongs to the rad9 family. (393 aa)
	RAD1	RAD1 checkpoint DNA exonuclease. (279 aa)
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	HUS1	Checkpoint protein; Belongs to the HUS1 family. (288 aa)
	MSH4	MutS homolog 4. (935 aa)
	FKBP6	Peptidylprolyl isomerase. (331 aa)
	BLM	BLM RecQ like helicase. (1429 aa)
	NIFK	Nucleolar protein interacting with the FHA domain of MKI67. (296 aa)
	LOC101117679	Uncharacterized protein. (206 aa)
	SYCP2L	Synaptonemal complex protein 2 like. (856 aa)
	SYCP3	Synaptonemal complex protein 3. (225 aa)
	SYCP2	Synaptonemal complex protein 2. (1260 aa)
	TEX11	Testis expressed 11. (920 aa)
	DSN1	DSN1 component of MIS12 kinetochore complex. (412 aa)
	TEX12	Testis expressed 12. (123 aa)
	CDYL	Chromodomain Y like. (546 aa)
	CDCA7	Cell division cycle associated 7. (452 aa)
	SYCE3	Synaptonemal complex central element protein 3. (87 aa)
	RCC1	Regulator of chromosome condensation 1. (422 aa)
	ZIM3	KRAB domain-containing protein. (174 aa)
	MIS12	Uncharacterized protein. (206 aa)
	LOC101102276	Uncharacterized protein. (201 aa)
	SHOC1	Shortage in chiasmata 1. (1511 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	CDCA7	ENSOARP00000013800	ENSOARP00000000593	BLM RecQ like helicase.	Cell division cycle associated 7.	0.481
BLM	CHEK1	ENSOARP00000013800	ENSOARP00000012490	BLM RecQ like helicase.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.841
BLM	HUS1	ENSOARP00000013800	ENSOARP00000013311	BLM RecQ like helicase.	Checkpoint protein; Belongs to the HUS1 family.	0.751
BLM	MLH3	ENSOARP00000013800	ENSOARP00000001705	BLM RecQ like helicase.	MutL homolog 3.	0.598
BLM	MSH4	ENSOARP00000013800	ENSOARP00000013633	BLM RecQ like helicase.	MutS homolog 4.	0.682
BLM	RAD1	ENSOARP00000013800	ENSOARP00000012426	BLM RecQ like helicase.	RAD1 checkpoint DNA exonuclease.	0.746
BLM	RAD9A	ENSOARP00000013800	ENSOARP00000012017	BLM RecQ like helicase.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.687
BLM	RAD9B	ENSOARP00000013800	ENSOARP00000018294	BLM RecQ like helicase.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.687
BLM	SPO11	ENSOARP00000013800	ENSOARP00000019324	BLM RecQ like helicase.	SPO11 initiator of meiotic double stranded breaks.	0.420
C14orf39	SYCE2	ENSOARP00000022707	ENSOARP00000010843	Chromosome 14 open reading frame 39.	Synaptonemal complex central element protein 2.	0.407
CCNB1IP1	MSH4	ENSOARP00000021245	ENSOARP00000013633	Cyclin B1 interacting protein 1.	MutS homolog 4.	0.463
CDCA7	BLM	ENSOARP00000000593	ENSOARP00000013800	Cell division cycle associated 7.	BLM RecQ like helicase.	0.481
CDCA7	CHEK1	ENSOARP00000000593	ENSOARP00000012490	Cell division cycle associated 7.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.539
CDCA7	HUS1	ENSOARP00000000593	ENSOARP00000013311	Cell division cycle associated 7.	Checkpoint protein; Belongs to the HUS1 family.	0.905
CDCA7	RAD1	ENSOARP00000000593	ENSOARP00000012426	Cell division cycle associated 7.	RAD1 checkpoint DNA exonuclease.	0.905
CDYL	SPO11	ENSOARP00000000051	ENSOARP00000019324	Chromodomain Y like.	SPO11 initiator of meiotic double stranded breaks.	0.541
CHEK1	BLM	ENSOARP00000012490	ENSOARP00000013800	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	BLM RecQ like helicase.	0.841
CHEK1	CDCA7	ENSOARP00000012490	ENSOARP00000000593	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Cell division cycle associated 7.	0.539
CHEK1	HUS1	ENSOARP00000012490	ENSOARP00000013311	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Checkpoint protein; Belongs to the HUS1 family.	0.704
CHEK1	RAD1	ENSOARP00000012490	ENSOARP00000012426	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	RAD1 checkpoint DNA exonuclease.	0.775