STRINGSTRING
SMOC1 SMOC1 W5NQ18_SHEEP W5NQ18_SHEEP W5NQ24_SHEEP W5NQ24_SHEEP THBS2-2 THBS2-2 W5NQ58_SHEEP W5NQ58_SHEEP PAPLN PAPLN W5NQX6_SHEEP W5NQX6_SHEEP W5NQY7_SHEEP W5NQY7_SHEEP PERP PERP DEFB123 DEFB123 PAQR4 PAQR4 MMRN2 MMRN2 RARRES2 RARRES2 RBP3 RBP3 LTBP2 LTBP2 W5NTY2_SHEEP W5NTY2_SHEEP FBLN2 FBLN2 FMOD FMOD PRELP PRELP SFRP2 SFRP2 OPTC OPTC HSPA12B HSPA12B MFAP5 MFAP5 W5NVE0_SHEEP W5NVE0_SHEEP TGFB3 TGFB3 EFEMP1 EFEMP1 OTOG OTOG ADAMTSL2 ADAMTSL2 GFOD2 GFOD2 CBY3 CBY3 EMID1 EMID1 VWA1 VWA1 NID1 NID1 MATN2 MATN2 ZP4 ZP4 SLC27A5 SLC27A5 ADNP2 ADNP2 BICC1 BICC1 NOSTRIN NOSTRIN CRYGN CRYGN ADAMTS10 ADAMTS10 LOXL1 LOXL1 THBS2 THBS2 DSPP DSPP COCH COCH COL17A1 COL17A1 CCBE1 CCBE1 ADAP1 ADAP1 ANGPT2 ANGPT2 W5P8Q1_SHEEP W5P8Q1_SHEEP ADAMTS6 ADAMTS6 SERPINB12 SERPINB12 W5P933_SHEEP W5P933_SHEEP COL4A2 COL4A2 TINAG TINAG LTBP4 LTBP4 FAM107B FAM107B GPLD1 GPLD1 SHH SHH AGRN AGRN PGM3 PGM3 RWDD2A RWDD2A ME1 ME1 BGN BGN ASPN ASPN NCAN NCAN SPARC SPARC ALG11 ALG11 APOE APOE BAG1 BAG1 LAMA4 LAMA4 ADAMTS4 ADAMTS4 ANOS1 ANOS1 POSTN POSTN EGFLAM EGFLAM LOXL2 LOXL2 LTBP1 LTBP1 OLFML2B OLFML2B COMP COMP AMELX AMELX ADAMTS9 ADAMTS9 COL15A1 COL15A1 TECTB TECTB TGFB2 TGFB2 ADAP2 ADAP2 ELN ELN ADAMTSL5 ADAMTSL5 W5PRH6_SHEEP W5PRH6_SHEEP W5PRL2_SHEEP W5PRL2_SHEEP FBLN5 FBLN5 LOC101113335 LOC101113335 COL18A1 COL18A1 COL6A1 COL6A1 COL6A2 COL6A2 W5PTZ8_SHEEP W5PTZ8_SHEEP PKHD1L1 PKHD1L1 MMP11 MMP11 CPZ CPZ OLFML2A OLFML2A GFOD1 GFOD1 ZP3 ZP3 FREM1 FREM1 CCN2 CCN2 SFSWAP SFSWAP ZP2 ZP2 RWDD2B RWDD2B COL26A1 COL26A1 ADAMTS5 ADAMTS5 ADAMTS1 ADAMTS1 TGFBI TGFBI LTBP3 LTBP3 W5Q1B4_SHEEP W5Q1B4_SHEEP EPYC EPYC KERA KERA DCN DCN TGFBR3 TGFBR3 OTOA OTOA GLP1R GLP1R CTXN1 CTXN1 PMP22 PMP22 PCSK6 PCSK6 FAM126B FAM126B CXorf58 CXorf58 SDC1 SDC1 F3 F3 THBS4 THBS4 CILP CILP COL8A1 COL8A1 W5Q937_SHEEP W5Q937_SHEEP VTN VTN SNED1 SNED1 ABI3BP ABI3BP TIMP3 TIMP3 MFAP4 MFAP4 ST8SIA4 ST8SIA4 GPC1 GPC1 COMT COMT ZPLD1 ZPLD1 C2orf80 C2orf80 MPV17 MPV17 SNORC SNORC W5QE00_SHEEP W5QE00_SHEEP SPDYA SPDYA ALK ALK IHH IHH THBS1 THBS1 KNL1 KNL1 W5QGE8_SHEEP W5QGE8_SHEEP LTK LTK P3H2 P3H2 COL4A3 COL4A3 ANXA2 ANXA2 CLEC7A CLEC7A FBN1 FBN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMOC1SPARC related modular calcium binding 1. (411 aa)
W5NQ18_SHEEPUncharacterized protein. (278 aa)
W5NQ24_SHEEPzf-CCHC_6 domain-containing protein. (249 aa)
THBS2-2EGF-like domain-containing protein. (191 aa)
W5NQ58_SHEEPUncharacterized protein. (123 aa)
PAPLNPapilin, proteoglycan like sulfated glycoprotein. (1271 aa)
W5NQX6_SHEEPBeta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa)
W5NQY7_SHEEPBeta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (69 aa)
PERPP53 apoptosis effector related to PMP22. (184 aa)
DEFB123Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
PAQR4Progestin and adipoQ receptor family member 4. (233 aa)
MMRN2Multimerin 2. (1002 aa)
RARRES2Retinoic acid receptor responder 2. (162 aa)
RBP3Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. (1286 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1961 aa)
W5NTY2_SHEEPUncharacterized protein. (576 aa)
FBLN2Uncharacterized protein. (268 aa)
FMODFibromodulin. (403 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (381 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
OPTCOpticin. (333 aa)
HSPA12BHeat shock protein family A (Hsp70) member 12B. (674 aa)
MFAP5Microfibril associated protein 5. (170 aa)
W5NVE0_SHEEPUncharacterized protein. (521 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (490 aa)
OTOGOtogelin. (2942 aa)
ADAMTSL2ADAMTS like 2. (916 aa)
GFOD2Glucose-fructose oxidoreductase domain containing 2. (385 aa)
CBY3Uncharacterized protein. (143 aa)
EMID1EMI domain-containing protein. (427 aa)
VWA1Von Willebrand factor A domain containing 1. (393 aa)
NID1Nidogen 1. (1242 aa)
MATN2Matrilin 2. (960 aa)
ZP4Zona pellucida glycoprotein 4. (540 aa)
SLC27A5Solute carrier family 27 member 5. (503 aa)
ADNP2ADNP homeobox 2. (1125 aa)
BICC1BicC family RNA binding protein 1. (972 aa)
NOSTRINNitric oxide synthase trafficking. (506 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (183 aa)
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10. (1028 aa)
LOXL1Lysyl oxidase like 1. (581 aa)
THBS2Thrombospondin 2. (1025 aa)
DSPPUncharacterized protein. (982 aa)
COCHCochlin. (552 aa)
COL17A1Collagen type XVII alpha 1 chain. (1478 aa)
CCBE1Collagen and calcium binding EGF domains 1. (336 aa)
ADAP1ArfGAP with dual PH domains 1. (348 aa)
ANGPT2Angiopoietin 2. (495 aa)
W5P8Q1_SHEEPzf-CCHC_6 domain-containing protein. (432 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1118 aa)
SERPINB12Serpin family B member 12; Belongs to the serpin family. (425 aa)
W5P933_SHEEPzf-CCHC_6 domain-containing protein. (422 aa)
COL4A2Collagen type IV alpha 2 chain. (1692 aa)
TINAGTubulointerstitial nephritis antigen; Belongs to the peptidase C1 family. (417 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1634 aa)
FAM107BUncharacterized protein. (154 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (848 aa)
SHHUncharacterized protein. (232 aa)
AGRNUncharacterized protein. (2043 aa)
PGM3Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family. (542 aa)
RWDD2ARWD domain containing 2A. (270 aa)
ME1Malic enzyme. (545 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (369 aa)
ASPNAsporin. (370 aa)
NCANNeurocan. (1355 aa)
SPARCKazal-like domain-containing protein. (462 aa)
ALG11ALG11 alpha-1,2-mannosyltransferase. (678 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (317 aa)
BAG1BCL2 associated athanogene 1. (270 aa)
LAMA4Laminin subunit alpha 4. (1824 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (851 aa)
ANOS1Anosmin 1. (566 aa)
POSTNPeriostin. (836 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (1026 aa)
LOXL2Lysyl oxidase like 2. (762 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1517 aa)
OLFML2BOlfactomedin like 2B. (761 aa)
COMPCartilage oligomeric matrix protein. (739 aa)
AMELXAmelogenin X-linked. (216 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1915 aa)
COL15A1Collagen type XV alpha 1 chain. (1375 aa)
TECTBTectorin beta. (329 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
ADAP2ArfGAP with dual PH domains 2. (381 aa)
ELNUncharacterized protein. (493 aa)
ADAMTSL5ADAMTS like 5. (469 aa)
W5PRH6_SHEEPUncharacterized protein. (119 aa)
W5PRL2_SHEEPUncharacterized protein. (210 aa)
FBLN5Fibulin 5. (448 aa)
LOC101113335RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (148 aa)
COL18A1Collagen type XVIII alpha 1 chain. (1678 aa)
COL6A1Uncharacterized protein. (1019 aa)
COL6A2Collagen type VI alpha 2 chain. (944 aa)
W5PTZ8_SHEEPRNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (147 aa)
PKHD1L1PKHD1 like 1. (4269 aa)
MMP11Matrix metallopeptidase 11. (486 aa)
CPZCarboxypeptidase Z. (644 aa)
OLFML2AOlfactomedin like 2A. (638 aa)
GFOD1Glucose-fructose oxidoreductase domain containing 1. (390 aa)
ZP3ZP domain-containing protein. (408 aa)
FREM1FRAS1 related extracellular matrix 1. (2187 aa)
CCN2Uncharacterized protein. (254 aa)
SFSWAPSplicing factor SWAP. (989 aa)
ZP2Zona pellucida glycoprotein 2. (714 aa)
RWDD2BRWD domain-containing protein. (300 aa)
COL26A1Collagen type XXVI alpha 1 chain. (477 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (922 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (968 aa)
TGFBITransforming growth factor beta induced. (645 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1167 aa)
W5Q1B4_SHEEPEMI domain-containing protein. (330 aa)
EPYCEpiphycan. (321 aa)
KERAKeratocan. (354 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
TGFBR3Transforming growth factor beta receptor 3. (857 aa)
OTOAOtoancorin. (1151 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
CTXN1Uncharacterized protein. (52 aa)
PMP22Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family. (160 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (887 aa)
FAM126BFamily with sequence similarity 126 member B. (586 aa)
CXorf58Chromosome X open reading frame 58. (372 aa)
SDC1Uncharacterized protein. (230 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
THBS4Thrombospondin 4. (932 aa)
CILPCartilage intermediate layer protein. (1181 aa)
COL8A1Collagen type VIII alpha 1 chain. (694 aa)
W5Q937_SHEEPUncharacterized protein. (80 aa)
VTNSMB domain-containing protein. (475 aa)
SNED1Sushi, nidogen and EGF like domains 1. (1332 aa)
ABI3BPABI family member 3 binding protein. (1702 aa)
TIMP3Metallopeptidase inhibitor 3. (211 aa)
MFAP4Microfibril associated protein 4. (193 aa)
ST8SIA4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (457 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (490 aa)
COMTUncharacterized protein. (67 aa)
ZPLD1Zona pellucida like domain containing 1. (431 aa)
C2orf80Chromosome 2 open reading frame 80. (194 aa)
MPV17Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family. (194 aa)
SNORCUncharacterized protein. (40 aa)
W5QE00_SHEEPUncharacterized protein. (67 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (312 aa)
ALKTyrosine-protein kinase receptor. (1012 aa)
IHHIndian hedgehog signaling molecule. (378 aa)
THBS1Thrombospondin 1. (1286 aa)
KNL1Kinetochore scaffold 1. (2344 aa)
W5QGE8_SHEEPUncharacterized protein. (576 aa)
LTKLeukocyte receptor tyrosine kinase. (863 aa)
P3H2Prolyl 3-hydroxylase 2. (708 aa)
COL4A3Collagen type IV alpha 3 chain. (1670 aa)
ANXA2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9; Belongs to the annexin family. (339 aa)
CLEC7AC-type lectin domain containing 7A. (262 aa)
FBN1Fibrillin 1. (2876 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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