44 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AGXT2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
	CTH	Cystathionine gamma-lyase. (417 aa)
	HDC	Histidine decarboxylase. (658 aa)
	SCLY	Selenocysteine lyase. (447 aa)
	SHMT1	Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (486 aa)
	AGXT	Serine--pyruvate aminotransferase. (401 aa)
	CSAD	Uncharacterized protein. (507 aa)
	GPT2	Glutamic--pyruvic transaminase 2. (523 aa)
	W5Q1I4_SHEEP	Aminotran_1_2 domain-containing protein. (269 aa)
	KYAT3	Kynurenine aminotransferase 3. (457 aa)
	GADL1	Glutamate decarboxylase like 1. (449 aa)
	NFS1	Aminotran_5 domain-containing protein. (453 aa)
	DDC	Dopa decarboxylase. (543 aa)
	GCAT	Glycine C-acetyltransferase. (430 aa)
	GLDC	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1025 aa)
	GOT1	Aspartate aminotransferase. (413 aa)
	PSAT1	Phosphoserine aminotransferase. (396 aa)
	GOT1L1	Glutamic-oxaloacetic transaminase 1 like 1. (461 aa)
	ACCSL	1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like. (610 aa)
	ACCS	1-aminocyclopropane-1-carboxylate synthase homolog (inactive). (508 aa)
	GOT2	Aspartate aminotransferase. (430 aa)
	GAD1	Glutamate decarboxylase 1. (599 aa)
	GPT	Glutamic--pyruvic transaminase. (535 aa)
	SPTLC2	Serine palmitoyltransferase long chain base subunit 2. (562 aa)
	AGXT-2	Aminotran_5 domain-containing protein. (108 aa)
	TAT	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (456 aa)
	GAD2	Glutamate decarboxylase 2. (578 aa)
	ABAT	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	W5P5R4_SHEEP	Beta_elim_lyase domain-containing protein. (383 aa)
	MOCOS	Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (849 aa)
	ALAS2	5-aminolevulinate synthase. (587 aa)
	W5P775_SHEEP	Uncharacterized protein. (543 aa)
	ALAS1	5'-aminolevulinate synthase 1. (665 aa)
	PHYKPL	5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
	SEPSECS	O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. (503 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa)
	ETNPPL	Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa)
	W5PCA2_SHEEP	Uncharacterized protein. (260 aa)
	SPTLC1	Serine palmitoyltransferase long chain base subunit 1. (475 aa)
	PDXDC1	Pyridoxal dependent decarboxylase domain containing 1. (790 aa)
	W5PHB0_SHEEP	Aminotran_1_2 domain-containing protein. (428 aa)
	KYNU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (463 aa)
	OAT	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
	SPTLC3	Serine palmitoyltransferase long chain base subunit 3. (549 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABAT	AGXT	ENSOARP00000005615	ENSOARP00000019659	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Serine--pyruvate aminotransferase.	0.461
ABAT	AGXT-2	ENSOARP00000005615	ENSOARP00000002779	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Aminotran_5 domain-containing protein.	0.461
ABAT	AGXT2	ENSOARP00000005615	ENSOARP00000012289	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.933
ABAT	CSAD	ENSOARP00000005615	ENSOARP00000017905	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.473
ABAT	DDC	ENSOARP00000005615	ENSOARP00000015447	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Dopa decarboxylase.	0.444
ABAT	GAD1	ENSOARP00000005615	ENSOARP00000002472	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamate decarboxylase 1.	0.945
ABAT	GAD2	ENSOARP00000005615	ENSOARP00000005214	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamate decarboxylase 2.	0.963
ABAT	GADL1	ENSOARP00000005615	ENSOARP00000015806	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamate decarboxylase like 1.	0.945
ABAT	GOT1	ENSOARP00000005615	ENSOARP00000013317	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Aspartate aminotransferase.	0.485
ABAT	GOT1L1	ENSOARP00000005615	ENSOARP00000001090	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamic-oxaloacetic transaminase 1 like 1.	0.427
ABAT	HDC	ENSOARP00000005615	ENSOARP00000022559	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Histidine decarboxylase.	0.436
ABAT	SEPSECS	ENSOARP00000005615	ENSOARP00000006951	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis.	0.428
ABAT	W5P775_SHEEP	ENSOARP00000005615	ENSOARP00000006279	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.973
ABAT	W5PCA2_SHEEP	ENSOARP00000005615	ENSOARP00000008063	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Uncharacterized protein.	0.473
ACCS	CTH	ENSOARP00000001583	ENSOARP00000012862	1-aminocyclopropane-1-carboxylate synthase homolog (inactive).	Cystathionine gamma-lyase.	0.459
ACCS	KYNU	ENSOARP00000001583	ENSOARP00000010657	1-aminocyclopropane-1-carboxylate synthase homolog (inactive).	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.561
ACCSL	CTH	ENSOARP00000001331	ENSOARP00000012862	1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like.	Cystathionine gamma-lyase.	0.459
ACCSL	KYNU	ENSOARP00000001331	ENSOARP00000010657	1-aminocyclopropane-1-carboxylate synthase homolog (inactive) like.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.561
AGXT	ABAT	ENSOARP00000019659	ENSOARP00000005615	Serine--pyruvate aminotransferase.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.461
AGXT	AGXT-2	ENSOARP00000019659	ENSOARP00000002779	Serine--pyruvate aminotransferase.	Aminotran_5 domain-containing protein.	0.858