8 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLR10	TIR domain-containing protein; Belongs to the Toll-like receptor family. (812 aa)
	W5QB52_SHEEP	TIR domain-containing protein. (119 aa)
	TLR1	Toll-like receptor. (796 aa)
	TLR6	Toll-like receptor. (797 aa)
	TLR5	TIR domain-containing protein; Belongs to the Toll-like receptor family. (871 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	TLR3	TIR domain-containing protein; Belongs to the Toll-like receptor family. (904 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TLR1	TLR2	ENSOARP00000000545	ENSOARP00000016139	Toll-like receptor.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.999
TLR1	TLR3	ENSOARP00000000545	ENSOARP00000008645	Toll-like receptor.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.633
TLR1	TLR4	ENSOARP00000000545	ENSOARP00000006210	Toll-like receptor.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.734
TLR1	TLR5	ENSOARP00000000545	ENSOARP00000005373	Toll-like receptor.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.582
TLR1	TLR6	ENSOARP00000000545	ENSOARP00000000565	Toll-like receptor.	Toll-like receptor.	0.977
TLR10	TLR2	ENSOARP00000000526	ENSOARP00000016139	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.670
TLR10	TLR3	ENSOARP00000000526	ENSOARP00000008645	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.469
TLR10	TLR4	ENSOARP00000000526	ENSOARP00000006210	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.657
TLR10	TLR5	ENSOARP00000000526	ENSOARP00000005373	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.551
TLR2	TLR1	ENSOARP00000016139	ENSOARP00000000545	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll-like receptor.	0.999
TLR2	TLR10	ENSOARP00000016139	ENSOARP00000000526	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.670
TLR2	TLR3	ENSOARP00000016139	ENSOARP00000008645	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.752
TLR2	TLR4	ENSOARP00000016139	ENSOARP00000006210	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.991
TLR2	TLR5	ENSOARP00000016139	ENSOARP00000005373	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.958
TLR2	TLR6	ENSOARP00000016139	ENSOARP00000000565	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	Toll-like receptor.	0.999
TLR3	TLR1	ENSOARP00000008645	ENSOARP00000000545	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor.	0.633
TLR3	TLR10	ENSOARP00000008645	ENSOARP00000000526	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.469
TLR3	TLR2	ENSOARP00000008645	ENSOARP00000016139	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.752
TLR3	TLR4	ENSOARP00000008645	ENSOARP00000006210	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.645
TLR3	TLR5	ENSOARP00000008645	ENSOARP00000005373	TIR domain-containing protein; Belongs to the Toll-like receptor family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.571