STRINGSTRING
VWA5A VWA5A VIT VIT CACHD1 CACHD1 ITGB8 ITGB8 ITGB4 ITGB4 RO60 RO60 W5PI72_SHEEP W5PI72_SHEEP VWA5B1 VWA5B1 ITGAD ITGAD CPNE4 CPNE4 ITGAX ITGAX CACNA2D2 CACNA2D2 ITGAM ITGAM VWF VWF VWA7 VWA7 MATN4 MATN4 COL28A1 COL28A1 HMCN1 HMCN1 LOC101118051 LOC101118051 COCH COCH COL21A1 COL21A1 COL12A1 COL12A1 ITGAL ITGAL CPNE9 CPNE9 SEC24B SEC24B SVEP1 SVEP1 ITGB6 ITGB6 VWA8 VWA8 HMCN2 HMCN2 PSMD4 PSMD4 ITGA10 ITGA10 VWA5B2 VWA5B2 SEC23A SEC23A ITGA1 ITGA1 ITGA2 ITGA2 SEC24C SEC24C ITGB5 ITGB5 CPNE8 CPNE8 ANTXR1 ANTXR1 XRCC5 XRCC5 CPNE6 CPNE6 COL6A3 COL6A3 CPNE2 CPNE2 ANTXR2 ANTXR2 ITGA11 ITGA11 XRCC6 XRCC6 INTS14 INTS14 ITGB1 ITGB1 W5Q759_SHEEP W5Q759_SHEEP MATN3 MATN3 SEC24D SEC24D COL14A1 COL14A1 ITGB7 ITGB7 CACNA2D1 CACNA2D1 CACNA2D3 CACNA2D3 ITIH4 ITIH4 W5NSC3_SHEEP W5NSC3_SHEEP ITIH3 ITIH3 W5NSL6_SHEEP W5NSL6_SHEEP W5NSP8_SHEEP W5NSP8_SHEEP ITIH1 ITIH1 MATN1 MATN1 C2 C2 GTF2H3 GTF2H3 VWA1 VWA1 MATN2 MATN2 COL22A1 COL22A1 VWA3A VWA3A W5PZW6_SHEEP W5PZW6_SHEEP COL6A5 COL6A5 W5PZN1_SHEEP W5PZN1_SHEEP LOC101116002 LOC101116002 CLCA4 CLCA4 COL6A6 COL6A6 CLCA1 CLCA1 CLCA2 CLCA2 VWA2 VWA2 CPNE1 CPNE1 PARP4 PARP4 SEC24A SEC24A CPNE7 CPNE7 CPNE5 CPNE5 ITIH2 ITIH2 VWA3B VWA3B MED25 MED25 ITIH5 ITIH5 COL6A2 COL6A2 CACNA2D4 CACNA2D4 COL6A1 COL6A1 MDN1 MDN1 ITGB2 ITGB2 CPNE3 CPNE3 ITGB3 ITGB3 INTS6L INTS6L W5PNP3_SHEEP W5PNP3_SHEEP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VWA5AVon Willebrand factor A domain containing 5A. (799 aa)
VITVitrin. (626 aa)
CACHD1Cache domain containing 1. (1223 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (743 aa)
ITGB4Integrin beta. (1835 aa)
RO60Ro60, Y RNA binding protein. (558 aa)
W5PI72_SHEEPSAP domain-containing protein. (565 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1178 aa)
ITGADVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1160 aa)
CPNE4VWFA domain-containing protein. (358 aa)
ITGAXIntegrin subunit alpha X; Belongs to the integrin alpha chain family. (1161 aa)
CACNA2D2Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (963 aa)
ITGAMVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1149 aa)
VWFVon Willebrand factor. (2694 aa)
VWA7Von Willebrand factor A domain containing 7. (881 aa)
MATN4Matrilin 4. (596 aa)
COL28A1Collagen type XXVIII alpha 1 chain. (1152 aa)
HMCN1Hemicentin 1. (5590 aa)
LOC101118051General transcription factor IIH subunit. (411 aa)
COCHCochlin. (552 aa)
COL21A1Collagen type XXI alpha 1 chain. (959 aa)
COL12A1Collagen type XII alpha 1 chain. (3125 aa)
ITGALVWFA domain-containing protein; Belongs to the integrin alpha chain family. (1164 aa)
CPNE9Copine family member 9. (553 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1214 aa)
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3550 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (787 aa)
VWA8Von Willebrand factor A domain containing 8. (1974 aa)
HMCN2Hemicentin 2. (5379 aa)
PSMD4Proteasome 26S non-ATPase subunit 4. (377 aa)
ITGA10Integrin subunit alpha 10; Belongs to the integrin alpha chain family. (1167 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1183 aa)
SEC23AProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
ITGA1Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1166 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1171 aa)
SEC24CSEC24 homolog C, COPII coat complex component. (1117 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
CPNE8Copine 8. (567 aa)
ANTXR1ANTXR cell adhesion molecule 1. (596 aa)
XRCC5X-ray repair cross complementing 5. (733 aa)
CPNE6Copine 6. (558 aa)
COL6A3Collagen type VI alpha 3 chain. (3154 aa)
CPNE2Copine 2. (548 aa)
ANTXR2Anthrax toxin receptor; Belongs to the ATR family. (488 aa)
ITGA11Integrin subunit alpha 11; Belongs to the integrin alpha chain family. (1184 aa)
XRCC6SAP domain-containing protein. (612 aa)
INTS14Integrator complex subunit 14. (533 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
W5Q759_SHEEPUncharacterized protein. (2875 aa)
MATN3Matrilin 3. (489 aa)
SEC24DSEC24 homolog D, COPII coat complex component. (1055 aa)
COL14A1Collagen type XIV alpha 1 chain. (1655 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1071 aa)
CACNA2D3Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (915 aa)
ITIH4Inter-alpha-trypsin inhibitor heavy chain 4. (917 aa)
W5NSC3_SHEEPVWFA domain-containing protein. (562 aa)
ITIH3Inter-alpha-trypsin inhibitor heavy chain 3. (891 aa)
W5NSL6_SHEEPVWFA domain-containing protein. (538 aa)
W5NSP8_SHEEPVWFA domain-containing protein. (1301 aa)
ITIH1Inter-alpha-trypsin inhibitor heavy chain 1. (912 aa)
MATN1Matrilin 1. (499 aa)
C2Uncharacterized protein; Belongs to the peptidase S1 family. (1244 aa)
GTF2H3General transcription factor IIH subunit 3. (305 aa)
VWA1Von Willebrand factor A domain containing 1. (393 aa)
MATN2Matrilin 2. (960 aa)
COL22A1Collagen type XXII alpha 1 chain. (1619 aa)
VWA3AVon Willebrand factor A domain containing 3A. (1177 aa)
W5PZW6_SHEEPUncharacterized protein. (762 aa)
COL6A5Collagen type VI alpha 5 chain. (2606 aa)
W5PZN1_SHEEPVWFA domain-containing protein. (724 aa)
LOC101116002VWFA domain-containing protein. (904 aa)
CLCA4Chloride channel accessory 4. (949 aa)
COL6A6Collagen type VI alpha 6 chain. (2265 aa)
CLCA1Chloride channel accessory 1. (960 aa)
CLCA2Chloride channel accessory 2. (1022 aa)
VWA2Von Willebrand factor A domain containing 2. (766 aa)
CPNE1Uncharacterized protein. (1487 aa)
PARP4Poly [ADP-ribose] polymerase. (1832 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1065 aa)
CPNE7Copine 7. (489 aa)
CPNE5Copine 5. (599 aa)
ITIH2Inter-alpha-trypsin inhibitor heavy chain 2. (946 aa)
VWA3BVon Willebrand factor A domain containing 3B. (1347 aa)
MED25Mediator complex subunit 25. (742 aa)
ITIH5Inter-alpha-trypsin inhibitor heavy chain 5. (935 aa)
COL6A2Collagen type VI alpha 2 chain. (944 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1089 aa)
COL6A1Uncharacterized protein. (1019 aa)
MDN1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5583 aa)
ITGB2Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...] (750 aa)
CPNE3Copine 3. (551 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
INTS6LIntegrator complex subunit 6 like. (859 aa)
W5PNP3_SHEEPUncharacterized protein. (424 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.