STRINGSTRING
PYGL PYGL BCAT1 BCAT1 SHMT1 SHMT1 AGXT AGXT PHYKPL PHYKPL SGPL1 SGPL1 CSAD CSAD W5P775_SHEEP W5P775_SHEEP ALAS2 ALAS2 MOCOS MOCOS ABAT ABAT GAD2 GAD2 TAT TAT SPTLC2 SPTLC2 GAD1 GAD1 PLPBP PLPBP GADL1 GADL1 DDC DDC GLDC GLDC CTH CTH AGXT2 AGXT2 CBS CBS SPTLC3 SPTLC3 OAT OAT KYNU KYNU PYGM PYGM W5PCA2_SHEEP W5PCA2_SHEEP ETNPPL ETNPPL SHMT2 SHMT2 PYGB PYGB HDC HDC SEPSECS SEPSECS THNSL2 THNSL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PYGLGlycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). (779 aa)
BCAT1Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (386 aa)
SHMT1Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine. (486 aa)
AGXTSerine--pyruvate aminotransferase. (401 aa)
PHYKPL5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (452 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
CSADUncharacterized protein. (507 aa)
W5P775_SHEEPUncharacterized protein. (543 aa)
ALAS25-aminolevulinate synthase. (587 aa)
MOCOSMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (849 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
GAD2Glutamate decarboxylase 2. (578 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (456 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
GAD1Glutamate decarboxylase 1. (599 aa)
PLPBPPyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (276 aa)
GADL1Glutamate decarboxylase like 1. (449 aa)
DDCDopa decarboxylase. (543 aa)
GLDCGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1025 aa)
CTHCystathionine gamma-lyase. (417 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (585 aa)
SPTLC3Serine palmitoyltransferase long chain base subunit 3. (549 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (439 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (463 aa)
PYGMGlycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
W5PCA2_SHEEPUncharacterized protein. (260 aa)
ETNPPLEthanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (497 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (343 aa)
PYGBGlycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (844 aa)
HDCHistidine decarboxylase. (658 aa)
SEPSECSO-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. (503 aa)
THNSL2Threonine synthase like 2. (485 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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