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| | LOC101116756 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (566 aa) |
| | CYP3A24 | Cytochrome P450 3A24; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (507 aa) |
| | W5QAD8_SHEEP | Uncharacterized protein. (181 aa) |
| | PAOX | Amino_oxidase domain-containing protein. (452 aa) |
| | LOC114108597 | Uncharacterized protein; Belongs to the cytochrome P450 family. (397 aa) |
| | CES5A | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family. (576 aa) |
| | FOXRED2 | FAD dependent oxidoreductase domain containing 2. (690 aa) |
| | W5QC92_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (472 aa) |
| | CYB5R3 | NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa) |
| | CYP27A1 | Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa) |
| | FMO5 | Dimethylaniline monooxygenase [N-oxide-forming]. (536 aa) |
| | CCNDBP1 | Cyclin D1 binding protein 1. (359 aa) |
| | W5QHH6_SHEEP | Uncharacterized protein. (508 aa) |
| | ARNT | Aryl-hydrocarbon receptor nuclear translocator. (790 aa) |
| | CYP19 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (424 aa) |
| | W5QJ23_SHEEP | TAFH domain-containing protein. (482 aa) |
| | W5P6Y5_SHEEP | Uncharacterized protein. (118 aa) |
| | W5P6V8_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (282 aa) |
| | LOC101107295 | Uncharacterized protein. (586 aa) |
| | LOC101113086 | Amine oxidase. (766 aa) |
| | AOC2 | Amine oxidase. (747 aa) |
| | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (By similarity). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into [...] (520 aa) |
| | LOC101115927 | Uncharacterized protein. (418 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1465 aa) |
| | LOC101115671 | Uncharacterized protein. (414 aa) |
| | CYB5B | Cytochrome b5 type B; Belongs to the cytochrome b5 family. (153 aa) |
| | ACSS1 | Acetyl-coenzyme A synthetase. (579 aa) |
| | CYP2R1 | Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (510 aa) |
| | CYP1A1 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] (452 aa) |
| | CYP4X1 | Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (562 aa) |
| | CYP1A2 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (521 aa) |
| | W5NZB0_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa) |
| | MAOB | Amine oxidase. (451 aa) |
| | W5NZ35_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (116 aa) |
| | W5NYZ2_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (519 aa) |
| | W5NYN9_SHEEP | Uncharacterized protein. (344 aa) |
| | MAOA | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (527 aa) |
| | LOC101105610 | Uncharacterized protein; Belongs to the cytochrome P450 family. (515 aa) |
| | CYP4B1 | Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa) |
| | CYP4F22 | Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (493 aa) |
| | W5NXH7_SHEEP | Uncharacterized protein. (377 aa) |
| | W5NXD3_SHEEP | Uncharacterized protein. (330 aa) |
| | CES4A | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (560 aa) |
| | CES3 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa) |
| | CES2 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (553 aa) |
| | W5NWR1_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa) |
| | RXRA | Retinoid X receptor alpha. (424 aa) |
| | W5NWG1_SHEEP | Uncharacterized protein. (427 aa) |
| | CYP11B1-2 | Cytochrome P450 11B1, mitochondrial. (124 aa) |
| | AIPL1 | Aryl hydrocarbon receptor interacting protein like 1. (328 aa) |
| | W5NVS0_SHEEP | ADH_N domain-containing protein. (126 aa) |
| | W5NVM3_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
| | W5NVD2_SHEEP | Uncharacterized protein. (419 aa) |
| | W5NUW3_SHEEP | Amine oxidase. (748 aa) |
| | W5NUV6_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (482 aa) |
| | AOC1 | Amine oxidase. (332 aa) |
| | NQO2 | N-ribosyldihydronicotinamide:quinone reductase 2. (233 aa) |
| | W5NUH5_SHEEP | Uncharacterized protein. (281 aa) |
| | CYP26A1 | Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa) |
| | LOC105613870 | Prostaglandin E2 omega-hydroxylase CYP4F21; A cytochrome P450 monooxygenase that catalyzes the omega- hydroxylation of prostaglandin E2. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). (523 aa) |
| | W5NTC3_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (120 aa) |
| | CYP26C1 | Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (505 aa) |
| | CYP4F21 | Uncharacterized protein; Belongs to the cytochrome P450 family. (411 aa) |
| | CYP46A1 | Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (465 aa) |
| | W5NRZ8_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (82 aa) |
| | CYP11B1 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (189 aa) |
| | W5NRQ8_SHEEP | Uncharacterized protein. (162 aa) |
| | W5NRG4_SHEEP | ADH_zinc_N domain-containing protein. (128 aa) |
| | W5NRF4_SHEEP | Amine oxidase; Belongs to the copper/topaquinone oxidase family. (533 aa) |
| | PTGES3 | Prostaglandin E synthase 3. (153 aa) |
| | CYP2U1 | Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (498 aa) |
| | W5PFM4_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (488 aa) |
| | LOC101121820 | Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa) |
| | W5PFZ2_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
| | CYP2J2 | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (539 aa) |
| | RUNX1T1 | RUNX1 partner transcriptional co-repressor 1. (603 aa) |
| | AHR | Uncharacterized protein. (842 aa) |
| | HSP90AB1 | Heat shock protein 90 alpha family class B member 1. (724 aa) |
| | ALDH2 | Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (520 aa) |
| | CYP39A1 | Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (469 aa) |
| | ACSS2 | Acyl-CoA synthetase short chain family member 2. (714 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | FAM78B | Family with sequence similarity 78 member B. (261 aa) |
| | W5PQ29_SHEEP | Dimethylaniline monooxygenase [N-oxide-forming]. (533 aa) |
| | AADACL3 | Arylacetamide deacetylase like 3. (414 aa) |
| | FADS6 | Fatty acid desaturase 6. (291 aa) |
| | TBXAS1 | Thromboxane A synthase 1. (543 aa) |
| | FDXR | NADPH:adrenodoxin oxidoreductase, mitochondrial. (489 aa) |
| | CCDC160 | Coiled-coil domain containing 160. (329 aa) |
| | FMO3 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) |
| | LOC101104591 | Dimethylaniline monooxygenase [N-oxide-forming]. (534 aa) |
| | FMO2 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) |
| | AIP | Peptidylprolyl isomerase. (330 aa) |
| | FMO1 | Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa) |
| | W5PT13_SHEEP | Uncharacterized protein. (521 aa) |
| | ALDH1A1 | Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo. (501 aa) |
| | PTGIS | Prostaglandin I2 synthase; Belongs to the cytochrome P450 family. (476 aa) |
| | FMO4 | Dimethylaniline monooxygenase [N-oxide-forming]. (547 aa) |
| | ALDH16A1 | Aldehyde dehydrogenase family 16 member A1. (807 aa) |
| | MARC2 | Mitochondrial amidoxime reducing component 2. (334 aa) |
| | MARC1 | MOSC domain-containing protein. (333 aa) |
| | FDX1 | Adrenodoxin; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Belongs to the adrenodoxin/putidaredoxin family. (138 aa) |
| | W5P608_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa) |
| | LOC101107056 | Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (509 aa) |
| | W5P581_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (189 aa) |
| | LOC101106641 | Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa) |
| | CYP4V2 | Cytochrome P450 family 4 subfamily V member 2; Belongs to the cytochrome P450 family. (527 aa) |
| | CBFA2T2 | Uncharacterized protein. (592 aa) |
| | CYP2S1 | Cytochrome P450 family 2 subfamily S member 1; Belongs to the cytochrome P450 family. (488 aa) |
| | POR | Cytochrome p450 oxidoreductase. (649 aa) |
| | W5PBM8_SHEEP | Uncharacterized protein. (170 aa) |
| | CYP2B6 | Cytochrome P450 family 2 subfamily B member 6. (454 aa) |
| | LOC105608805 | Uncharacterized protein; Belongs to the cytochrome P450 family. (493 aa) |
| | W5PB74_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | CYP2A6 | Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa) |
| | CYP2F1 | Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (515 aa) |
| | W5PAW1_SHEEP | Uncharacterized protein. (487 aa) |
| | FAM78A | Family with sequence similarity 78 member A. (337 aa) |
| | LOC101120535 | Uncharacterized protein. (495 aa) |
| | CBFA2T3 | CBFA2/RUNX1 partner transcriptional co-repressor 3. (609 aa) |
| | CBR3 | Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (277 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | CYP8B1 | Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (499 aa) |
| | PTGS1 | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells. (593 aa) |
| | CMBL | Carboxymethylenebutenolidase homolog. (242 aa) |
| | CYP24A1 | Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa) |
| | LOC101111965 | PKS_ER domain-containing protein. (378 aa) |
| | ARNT2 | Uncharacterized protein. (751 aa) |
| | CYP7A1 | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (502 aa) |
| | W5Q247_SHEEP | PKS_ER domain-containing protein. (375 aa) |
| | ADH5 | S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa) |
| | W5Q2H7_SHEEP | BHLH domain-containing protein. (577 aa) |
| | FDX2 | 2Fe-2S ferredoxin-type domain-containing protein. (185 aa) |
| | CYP27C1 | Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (480 aa) |
| | CYP7B1 | Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (506 aa) |
| | EPHX1 | Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (451 aa) |
| | CYP51A1 | Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (510 aa) |
| | ALDH3A1 | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (451 aa) |
| | NCOA1 | Nuclear receptor coactivator. (1441 aa) |
| | LOC101110727 | Uncharacterized protein. (507 aa) |
| | CYP20A1 | Cytochrome P450 family 20 subfamily A member 1. (462 aa) |
| | LOC101116336 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa) |
| | POMC | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate. (254 aa) |
| | W5NRD8_SHEEP | Uncharacterized protein. (136 aa) |
| | W5NR17_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (217 aa) |
| | W5NQS5_SHEEP | Amine oxidase. (617 aa) |
| | TTI2 | TELO2 interacting protein 2. (503 aa) |
| | SMOX | Spermine oxidase. (555 aa) |
| | W5NQ21_SHEEP | Amine oxidase; Belongs to the copper/topaquinone oxidase family. (136 aa) |
| | W5NQ05_SHEEP | Uncharacterized protein. (82 aa) |
| | W5NPP3_SHEEP | Uncharacterized protein; Belongs to the cytochrome P450 family. (457 aa) |
| | W5NPH0_SHEEP | Uncharacterized protein. (122 aa) |
| | CYP2E1 | Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa) |
