STRINGSTRING
BAMBI BAMBI W5PZY7_SHEEP W5PZY7_SHEEP TGFBR2 TGFBR2 STUB1 STUB1 FURIN FURIN PPP1R15A PPP1R15A PCSK4 PCSK4 ITGB3 ITGB3 TGFB2 TGFB2 KXD1 KXD1 UBA52 UBA52 TGFBR1 TGFBR1 MTMR4 MTMR4 LTBP1 LTBP1 ITGB8 ITGB8 ITGA8 ITGA8 W5PE86_SHEEP W5PE86_SHEEP TGFB1 TGFB1 ITGB6 ITGB6 LTBP4 LTBP4 ZFYVE9 ZFYVE9 W5P3M9_SHEEP W5P3M9_SHEEP SMAD4 SMAD4 W5P1I7_SHEEP W5P1I7_SHEEP SMAD7 SMAD7 SMAD2 SMAD2 RPS27A RPS27A LDLRAD4 LDLRAD4 TGFB3 TGFB3 LTBP2 LTBP2 NEDD8 NEDD8 W5QC66_SHEEP W5QC66_SHEEP FBN1 FBN1 STRAP STRAP ITGB5 ITGB5 FKBP1A FKBP1A SMAD3 SMAD3 W5QA57_SHEEP W5QA57_SHEEP UBC UBC ITGB1 ITGB1 PMEPA1 PMEPA1 ITGAV ITGAV W5Q3X2_SHEEP W5Q3X2_SHEEP SMURF2 SMURF2 LTBP3 LTBP3 CBL CBL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family. (235 aa)
W5PZY7_SHEEPUbiquitin-like domain-containing protein. (171 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (568 aa)
STUB1STIP1 homology and U-box containing protein 1. (288 aa)
FURINP/Homo B domain-containing protein; Belongs to the peptidase S8 family. (712 aa)
PPP1R15AProtein phosphatase 1 regulatory subunit 15A. (666 aa)
PCSK4Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. (701 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (778 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (415 aa)
KXD1KxDL motif containing 1. (183 aa)
UBA52Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] (128 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
MTMR4Myotubularin related protein 4. (1196 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1517 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (743 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1064 aa)
W5PE86_SHEEPPeptidylprolyl isomerase. (143 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ITGB6Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). (787 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1634 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1424 aa)
W5P3M9_SHEEPUbiquitin-like domain-containing protein. (133 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
W5P1I7_SHEEPUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (148 aa)
SMAD7MH2 domain-containing protein. (257 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
RPS27AUbiquitin-like domain-containing protein. (171 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (312 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (452 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1961 aa)
NEDD8NEDD8 ubiquitin like modifier. (77 aa)
W5QC66_SHEEPUbiquitin-like domain-containing protein. (120 aa)
FBN1Fibrillin 1. (2876 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (802 aa)
FKBP1APeptidylprolyl isomerase. (103 aa)
SMAD3Mothers against decapentaplegic homolog. (316 aa)
W5QA57_SHEEPMH1 domain-containing protein. (106 aa)
UBCUbiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (538 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (285 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1051 aa)
W5Q3X2_SHEEPPeptidylprolyl isomerase. (108 aa)
SMURF2E3 ubiquitin-protein ligase. (732 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1167 aa)
CBLCbl proto-oncogene. (851 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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