24 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAP1B	RAP1B, member of RAS oncogene family. (184 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1035 aa)
	RASGRP1	RAS guanyl releasing protein 1. (797 aa)
	RAP1A	RAP1A, member of RAS oncogene family. (184 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (925 aa)
	YWHAZ	14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). (247 aa)
	SIPA1	Signal-induced proliferation-associated 1. (1062 aa)
	RAP1GAP2	RAP1 GTPase activating protein 2. (712 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (648 aa)
	THAP6	THAP domain containing 6. (222 aa)
	W5PZE0_SHEEP	Uncharacterized protein. (85 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (397 aa)
	PRKG1	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily. (471 aa)
	RAPGEFL1	Rap guanine nucleotide exchange factor like 1. (576 aa)
	RAPGEF5	Rap guanine nucleotide exchange factor 5. (808 aa)
	W5PHF9_SHEEP	DEP domain-containing protein. (113 aa)
	RASGRP2	RAS guanyl releasing protein 2. (667 aa)
	RAP1GAP	RAP1 GTPase activating protein. (729 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] (349 aa)
	SIPA1L3	Signal induced proliferation associated 1 like 3. (1303 aa)
	W5P3B5_SHEEP	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (245 aa)
	YWHAB	14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (282 aa)
	SIPA1L2	Signal induced proliferation associated 1 like 2. (1719 aa)
	W5NZE2_SHEEP	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (221 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PRKACA	PRKACB	ENSOARP00000006933	ENSOARP00000014812	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.900
PRKACA	PRKG1	ENSOARP00000006933	ENSOARP00000014606	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily.	0.573
PRKACA	RAF1	ENSOARP00000006933	ENSOARP00000016772	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Raf-1 proto-oncogene, serine/threonine kinase.	0.913
PRKACA	RAP1A	ENSOARP00000006933	ENSOARP00000021086	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	RAP1A, member of RAS oncogene family.	0.923
PRKACA	RAP1B	ENSOARP00000006933	ENSOARP00000001075	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	RAP1B, member of RAS oncogene family.	0.924
PRKACA	RAP1GAP	ENSOARP00000006933	ENSOARP00000009090	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	RAP1 GTPase activating protein.	0.549
PRKACA	W5PZE0_SHEEP	ENSOARP00000006933	ENSOARP00000015826	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	Uncharacterized protein.	0.627
PRKACB	PRKACA	ENSOARP00000014812	ENSOARP00000006933	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.900
PRKACB	PRKG1	ENSOARP00000014812	ENSOARP00000014606	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily.	0.581
PRKACB	RAF1	ENSOARP00000014812	ENSOARP00000016772	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	Raf-1 proto-oncogene, serine/threonine kinase.	0.914
PRKACB	RAP1A	ENSOARP00000014812	ENSOARP00000021086	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	RAP1A, member of RAS oncogene family.	0.923
PRKACB	RAP1B	ENSOARP00000014812	ENSOARP00000001075	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	RAP1B, member of RAS oncogene family.	0.925
PRKACB	RAP1GAP	ENSOARP00000014812	ENSOARP00000009090	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	RAP1 GTPase activating protein.	0.549
PRKACB	W5PZE0_SHEEP	ENSOARP00000014812	ENSOARP00000015826	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.619
PRKG1	PRKACA	ENSOARP00000014606	ENSOARP00000006933	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.573
PRKG1	PRKACB	ENSOARP00000014606	ENSOARP00000014812	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.581
PRKG1	RAF1	ENSOARP00000014606	ENSOARP00000016772	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily.	Raf-1 proto-oncogene, serine/threonine kinase.	0.906
PRKG1	RAP1GAP	ENSOARP00000014606	ENSOARP00000009090	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily.	RAP1 GTPase activating protein.	0.519
PRKG1	THAP6	ENSOARP00000014606	ENSOARP00000016444	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily.	THAP domain containing 6.	0.565
PRKG1	W5PZE0_SHEEP	ENSOARP00000014606	ENSOARP00000015826	Protein kinase cGMP-dependent 1; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.807