33 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSOARP00000019990	annotation not available (119 aa)
	S100A8	S100 calcium binding protein A8; Belongs to the S-100 family. (97 aa)
	W5NQR6_SHEEP	Uncharacterized protein. (222 aa)
	TLR1	Toll-like receptor. (796 aa)
	TLR6	Toll-like receptor. (797 aa)
	GSDMD	Gasdermin D. (461 aa)
	S100A1	Protein S100; Belongs to the S-100 family. (147 aa)
	W5NUD7_SHEEP	C-type lectin domain-containing protein. (375 aa)
	W5NXU4_SHEEP	C-type lectin domain-containing protein. (357 aa)
	W5P5Q1_SHEEP	Uncharacterized protein. (209 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
	LY96	Lymphocyte antigen 96. (160 aa)
	W5P9E9_SHEEP	Uncharacterized protein. (551 aa)
	W5P9J7_SHEEP	DUF1943 domain-containing protein. (429 aa)
	W5P9K7_SHEEP	Vitellogenin domain-containing protein. (433 aa)
	SFTPD	C-type lectin domain-containing protein. (369 aa)
	W5PK77_SHEEP	C-type lectin domain-containing protein. (305 aa)
	MBLA	C-type lectin domain-containing protein. (248 aa)
	SFTPA1	Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. (257 aa)
	GSDME	Gasdermin E. (495 aa)
	W5PPS0_SHEEP	Uncharacterized protein. (201 aa)
	W5PQP5_SHEEP	Uncharacterized protein. (214 aa)
	GSDMB	Gasdermin B. (412 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	FGG	Fibrinogen gamma chain. (434 aa)
	W5Q6C9_SHEEP	Uncharacterized protein; Belongs to the CD36 family. (436 aa)
	LOC101114861	Uncharacterized protein; Belongs to the CD36 family. (472 aa)
	HMGB1	Uncharacterized protein. (203 aa)
	W5Q6N3_SHEEP	Uncharacterized protein; Belongs to the CD36 family. (472 aa)
	APOB	Apolipoprotein B. (4549 aa)
	W5QB52_SHEEP	TIR domain-containing protein. (119 aa)
	LBP	Lipopolysaccharide binding protein. (540 aa)
	CD14	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (371 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOB	FGG	ENSOARP00000018682	ENSOARP00000017896	Apolipoprotein B.	Fibrinogen gamma chain.	0.603
APOB	LOC101114861	ENSOARP00000018682	ENSOARP00000018322	Apolipoprotein B.	Uncharacterized protein; Belongs to the CD36 family.	0.681
APOB	TLR4	ENSOARP00000018682	ENSOARP00000006210	Apolipoprotein B.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.540
APOB	TLR6	ENSOARP00000018682	ENSOARP00000000565	Apolipoprotein B.	Toll-like receptor.	0.709
APOB	W5Q6C9_SHEEP	ENSOARP00000018682	ENSOARP00000018269	Apolipoprotein B.	Uncharacterized protein; Belongs to the CD36 family.	0.681
APOB	W5Q6N3_SHEEP	ENSOARP00000018682	ENSOARP00000018374	Apolipoprotein B.	Uncharacterized protein; Belongs to the CD36 family.	0.681
CD14	LBP	ENSOARP00000022806	ENSOARP00000020212	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Lipopolysaccharide binding protein.	0.891
CD14	LY96	ENSOARP00000022806	ENSOARP00000006827	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Lymphocyte antigen 96.	0.984
CD14	S100A8	ENSOARP00000022806	ENSOARP00000000449	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	S100 calcium binding protein A8; Belongs to the S-100 family.	0.478
CD14	TLR2	ENSOARP00000022806	ENSOARP00000016139	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.959
CD14	TLR4	ENSOARP00000022806	ENSOARP00000006210	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.992
CD14	TLR6	ENSOARP00000022806	ENSOARP00000000565	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	Toll-like receptor.	0.533
ENSOARP00000019990	LY96	ENSOARP00000019990	ENSOARP00000006827	annotation not available	Lymphocyte antigen 96.	0.664
ENSOARP00000019990	TLR4	ENSOARP00000019990	ENSOARP00000006210	annotation not available	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.519
FGG	APOB	ENSOARP00000017896	ENSOARP00000018682	Fibrinogen gamma chain.	Apolipoprotein B.	0.603
GSDMB	GSDMD	ENSOARP00000013168	ENSOARP00000000589	Gasdermin B.	Gasdermin D.	0.471
GSDMB	GSDME	ENSOARP00000013168	ENSOARP00000011516	Gasdermin B.	Gasdermin E.	0.691
GSDMD	GSDMB	ENSOARP00000000589	ENSOARP00000013168	Gasdermin D.	Gasdermin B.	0.471
GSDMD	GSDME	ENSOARP00000000589	ENSOARP00000011516	Gasdermin D.	Gasdermin E.	0.802
GSDMD	HMGB1	ENSOARP00000000589	ENSOARP00000018330	Gasdermin D.	Uncharacterized protein.	0.649