STRINGSTRING
W5Q7S2_SHEEP W5Q7S2_SHEEP W5P3F4_SHEEP W5P3F4_SHEEP W5P3J4_SHEEP W5P3J4_SHEEP SF3B3 SF3B3 POLR2I POLR2I W5P5Y1_SHEEP W5P5Y1_SHEEP ZMAT5 ZMAT5 POLR2B POLR2B W5P7P2_SHEEP W5P7P2_SHEEP GTF2F1 GTF2F1 W5P851_SHEEP W5P851_SHEEP SNRPB SNRPB ZCRB1 ZCRB1 W5QGC2_SHEEP W5QGC2_SHEEP NCBP2 NCBP2 YBX1 YBX1 POLR2H POLR2H SF3B4 SF3B4 YBX3 YBX3 NCBP1 NCBP1 YBX2 YBX2 SNRPF SNRPF ZRSR2 ZRSR2 PRPF8 PRPF8 DDX42 DDX42 POLR2A POLR2A SNRNP200 SNRNP200 SNRPD3 SNRPD3 POLR2J POLR2J W5PYZ4_SHEEP W5PYZ4_SHEEP POLR2F POLR2F SF3B1 SF3B1 POLR2L POLR2L POLR2D POLR2D SNRPD2-2 SNRPD2-2 POLR2G POLR2G SNRNP48 SNRNP48 SF3B6 SF3B6 RNPC3 RNPC3 DDX23 DDX23 SNRPG SNRPG W5QDY3_SHEEP W5QDY3_SHEEP POLR2E POLR2E W5PMA1_SHEEP W5PMA1_SHEEP SNRNP25 SNRNP25 SNRPD2 SNRPD2 EFTUD2 EFTUD2 PRPF6 PRPF6 SRSF7 SRSF7 W5PEQ9_SHEEP W5PEQ9_SHEEP GTF2F2 GTF2F2 W5PBT8_SHEEP W5PBT8_SHEEP W5PA08_SHEEP W5PA08_SHEEP W5NPV2_SHEEP W5NPV2_SHEEP POLR2C POLR2C LOC101106173 LOC101106173 POLR2K POLR2K SNRNP40 SNRNP40 SF3B2 SF3B2 SF3B5 SF3B5 SNRPD1 SNRPD1 TXNL4A TXNL4A LOC101108423 LOC101108423 SNRNP35 SNRNP35
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5Q7S2_SHEEPSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
W5P3F4_SHEEPCSD_1 domain-containing protein. (344 aa)
W5P3J4_SHEEPCSD domain-containing protein. (201 aa)
SF3B3Splicing factor 3b subunit 3. (1220 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
W5P5Y1_SHEEPCSD_1 domain-containing protein. (352 aa)
ZMAT5Zinc finger matrin-type 5. (173 aa)
POLR2BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1175 aa)
W5P7P2_SHEEPSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (526 aa)
W5P851_SHEEPSmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (92 aa)
SNRPBSmall nuclear ribonucleoprotein-associated protein. (231 aa)
ZCRB1Zinc finger CCHC-type and RNA binding motif containing 1. (217 aa)
W5QGC2_SHEEPGeneral transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (312 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
YBX1CSD_1 domain-containing protein. (340 aa)
POLR2HDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
SF3B4Uncharacterized protein. (424 aa)
YBX3Y-box binding protein 3. (295 aa)
NCBP1Nuclear cap binding protein subunit 1. (792 aa)
YBX2Y-box binding protein 2. (355 aa)
SNRPFSmall nuclear ribonucleoprotein polypeptide F. (115 aa)
ZRSR2Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2. (468 aa)
PRPF8Pre-mRNA processing factor 8. (2338 aa)
DDX42DEAD-box helicase 42. (948 aa)
POLR2ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1890 aa)
SNRNP200Small nuclear ribonucleoprotein U5 subunit 200. (2124 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
POLR2JRNA polymerase II subunit J. (120 aa)
W5PYZ4_SHEEPUncharacterized protein. (366 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
SF3B1Splicing factor 3b subunit 1. (1304 aa)
POLR2LUncharacterized protein. (35 aa)
POLR2DRNA polymerase II subunit D. (142 aa)
SNRPD2-2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
POLR2GS1 domain-containing protein. (211 aa)
SNRNP48Small nuclear ribonucleoprotein U11/U12 subunit 48. (287 aa)
SF3B6Splicing factor 3b subunit 6. (125 aa)
RNPC3RNA binding region (RNP1, RRM) containing 3. (517 aa)
DDX23DEAD-box helicase 23. (909 aa)
SNRPGSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
W5QDY3_SHEEPSplicing factor 3B subunit 5; Belongs to the SF3B5 family. (83 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
W5PMA1_SHEEPUncharacterized protein. (393 aa)
SNRNP25Small nuclear ribonucleoprotein U11/U12 subunit 25. (139 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
EFTUD2Elongation factor Tu GTP binding domain containing 2. (998 aa)
PRPF6Pre-mRNA processing factor 6. (944 aa)
SRSF7Serine and arginine rich splicing factor 7. (241 aa)
W5PEQ9_SHEEPUncharacterized protein. (236 aa)
GTF2F2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (249 aa)
W5PBT8_SHEEPUncharacterized protein. (404 aa)
W5PA08_SHEEPNuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (150 aa)
W5NPV2_SHEEPSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
POLR2CRNA polymerase II subunit C. (275 aa)
LOC101106173Uncharacterized protein. (217 aa)
POLR2KRNA polymerase II subunit K. (58 aa)
SNRNP40Small nuclear ribonucleoprotein U5 subunit 40. (361 aa)
SF3B2Splicing factor 3b subunit 2. (876 aa)
SF3B5Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (133 aa)
TXNL4AThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
LOC101108423Uncharacterized protein. (217 aa)
SNRNP35Small nuclear ribonucleoprotein U11/U12 subunit 35. (245 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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