STRINGSTRING
W5NPV2_SHEEP W5NPV2_SHEEP SNRPF SNRPF THOC7 THOC7 NCBP1 NCBP1 SARNP SARNP U2AF1 U2AF1 SYMPK SYMPK CLP1 CLP1 CDC40 CDC40 LSM10 LSM10 THOC1 THOC1 DDX39B DDX39B SRSF7 SRSF7 W5PEQ9_SHEEP W5PEQ9_SHEEP W5PDD3_SHEEP W5PDD3_SHEEP ZC3H13 ZC3H13 W5PA08_SHEEP W5PA08_SHEEP ZNF318 ZNF318 SNRPB SNRPB SRRM1 SRRM1 MAGOH MAGOH W5P851_SHEEP W5P851_SHEEP W5P7P2_SHEEP W5P7P2_SHEEP SREK1 SREK1 DDX39A DDX39A PCF11 PCF11 W5P512_SHEEP W5P512_SHEEP U2AF1L4 U2AF1L4 THOC5 THOC5 W5P2T3_SHEEP W5P2T3_SHEEP DHX38 DHX38 W5P0A8_SHEEP W5P0A8_SHEEP W5NYX3_SHEEP W5NYX3_SHEEP SRSF6 SRSF6 W5NX43_SHEEP W5NX43_SHEEP SRSF4 SRSF4 EIF4A3 EIF4A3 SRSF11 SRSF11 WDR25 WDR25 ZC3H11A ZC3H11A U2AF2 U2AF2 CSTF2 CSTF2 THOC6 THOC6 CHTOP CHTOP SRSF9 SRSF9 CPSF2 CPSF2 CPSF7 CPSF7 CASC3 CASC3 SLU7 SLU7 W5PVJ2_SHEEP W5PVJ2_SHEEP SRSF3 SRSF3 W5PVU9_SHEEP W5PVU9_SHEEP W5PW24_SHEEP W5PW24_SHEEP W5PW42_SHEEP W5PW42_SHEEP ZNF473 ZNF473 SNRPD3 SNRPD3 CPSF3 CPSF3 C12orf50 C12orf50 WDR33 WDR33 MAGOHB MAGOHB RBM8A RBM8A CPSF6 CPSF6 TPRG1 TPRG1 NCBP2 NCBP2 FYTTD1 FYTTD1 SNRPG SNRPG BCL2L2-PABPN1 BCL2L2-PABPN1 W5QCU3_SHEEP W5QCU3_SHEEP POLDIP3 POLDIP3 FIP1L1 FIP1L1 CPSF4 CPSF4 NUDT21 NUDT21 CSTF1 CSTF1 RNPS1 RNPS1 SRSF6-2 SRSF6-2 ALYREF ALYREF W5Q7S2_SHEEP W5Q7S2_SHEEP W5Q7C1_SHEEP W5Q7C1_SHEEP CSTF3 CSTF3 THOC3 THOC3 PAPOLA PAPOLA TPRG1L TPRG1L W5Q453_SHEEP W5Q453_SHEEP SLBP SLBP W5Q3F1_SHEEP W5Q3F1_SHEEP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
W5NPV2_SHEEPSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
SNRPFSmall nuclear ribonucleoprotein polypeptide F. (115 aa)
THOC7THO complex 7. (198 aa)
NCBP1Nuclear cap binding protein subunit 1. (792 aa)
SARNPSAP domain containing ribonucleoprotein. (210 aa)
U2AF1Uncharacterized protein. (206 aa)
SYMPKSymplekin. (1266 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (428 aa)
CDC40Cell division cycle 40. (655 aa)
LSM10LSM10, U7 small nuclear RNA associated. (122 aa)
THOC1THO complex 1. (661 aa)
DDX39BDExD-box helicase 39B. (436 aa)
SRSF7Serine and arginine rich splicing factor 7. (241 aa)
W5PEQ9_SHEEPUncharacterized protein. (236 aa)
W5PDD3_SHEEPSmg4_UPF3 domain-containing protein. (388 aa)
ZC3H13Zinc finger CCCH-type containing 13. (1643 aa)
W5PA08_SHEEPNuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (150 aa)
ZNF318Zinc finger protein 318. (1970 aa)
SNRPBSmall nuclear ribonucleoprotein-associated protein. (231 aa)
SRRM1Serine and arginine repetitive matrix 1. (852 aa)
MAGOHMago homolog, exon junction complex subunit. (146 aa)
W5P851_SHEEPSmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (92 aa)
W5P7P2_SHEEPSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
SREK1Splicing regulatory glutamic acid and lysine rich protein 1. (632 aa)
DDX39ADExD-box helicase 39A. (471 aa)
PCF11PCF11 cleavage and polyadenylation factor subunit. (1645 aa)
W5P512_SHEEPUncharacterized protein; Belongs to the DEAD box helicase family. (410 aa)
U2AF1L4Uncharacterized protein. (234 aa)
THOC5THO complex 5. (683 aa)
W5P2T3_SHEEPRRM domain-containing protein. (229 aa)
DHX38DEAH-box helicase 38. (1230 aa)
W5P0A8_SHEEPUncharacterized protein. (1263 aa)
W5NYX3_SHEEPCCHC-type domain-containing protein. (461 aa)
SRSF6Serine and arginine rich splicing factor 6. (343 aa)
W5NX43_SHEEPUncharacterized protein. (222 aa)
SRSF4Serine and arginine rich splicing factor 4. (305 aa)
EIF4A3Uncharacterized protein; Belongs to the DEAD box helicase family. (411 aa)
SRSF11Serine and arginine rich splicing factor 11. (477 aa)
WDR25WD repeat domain 25. (528 aa)
ZC3H11AUncharacterized protein. (816 aa)
U2AF2U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (475 aa)
CSTF2Cleavage stimulation factor subunit 2. (594 aa)
THOC6THO complex 6. (341 aa)
CHTOPChromatin target of PRMT1. (264 aa)
SRSF9Serine and arginine rich splicing factor 9. (256 aa)
CPSF2Cleavage and polyadenylation specificity factor subunit 2. (763 aa)
CPSF7Cleavage and polyadenylation specific factor 7. (520 aa)
CASC3CASC3 exon junction complex subunit. (804 aa)
SLU7SLU7 homolog, splicing factor. (585 aa)
W5PVJ2_SHEEPPAP_central domain-containing protein. (67 aa)
SRSF3Pre-mRNA splicing factor SRP20-like protein. (164 aa)
W5PVU9_SHEEPCPSF_A domain-containing protein. (737 aa)
W5PW24_SHEEPUncharacterized protein. (1569 aa)
W5PW42_SHEEPRRM domain-containing protein. (632 aa)
ZNF473Uncharacterized protein. (245 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (684 aa)
C12orf50Chromosome 12 open reading frame 50. (419 aa)
WDR33WD repeat domain 33. (1336 aa)
MAGOHBMago homolog B, exon junction complex subunit. (148 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
CPSF6Cleavage and polyadenylation specific factor 6. (571 aa)
TPRG1Tumor protein p63 regulated 1. (280 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
FYTTD1Uncharacterized protein. (322 aa)
SNRPGSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
BCL2L2-PABPN1BCL2L2-PABPN1 readthrough. (363 aa)
W5QCU3_SHEEPRRM domain-containing protein. (623 aa)
POLDIP3DNA polymerase delta interacting protein 3. (421 aa)
FIP1L1Fip1 domain-containing protein. (532 aa)
CPSF4Cleavage and polyadenylation specific factor 4. (273 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
CSTF1Cleavage stimulation factor subunit 1. (472 aa)
RNPS1RNA binding protein with serine rich domain 1. (359 aa)
SRSF6-2RRM domain-containing protein. (267 aa)
ALYREFAly/REF export factor. (267 aa)
W5Q7S2_SHEEPSmall nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
W5Q7C1_SHEEPRRM domain-containing protein. (157 aa)
CSTF3Cleavage stimulation factor subunit 3. (651 aa)
THOC3THO complex 3. (351 aa)
PAPOLAPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (755 aa)
TPRG1LTumor protein p63 regulated 1 like. (230 aa)
W5Q453_SHEEPSLBP_RNA_bind domain-containing protein. (190 aa)
SLBPStem-loop binding protein. (217 aa)
W5Q3F1_SHEEPSmg4_UPF3 domain-containing protein. (486 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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