11 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	W5PIX3_SHEEP	Uncharacterized protein. (184 aa)
	CYB5R3	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa)
	CYB5R1	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (305 aa)
	NOS2	Nitric oxide synthase; Produces nitric oxide (NO). (1154 aa)
	CYB5R2	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (298 aa)
	OXNAD1	Oxidoreductase NAD binding domain containing 1. (311 aa)
	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (723 aa)
	LOC101122662	Uncharacterized protein. (526 aa)
	NOS3	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)
	NOS1	Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
	CYB5RL	FAD-binding FR-type domain-containing protein. (315 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYB5R1	LOC101122662	ENSOARP00000019404	ENSOARP00000014406	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Uncharacterized protein.	0.429
CYB5R1	W5PIX3_SHEEP	ENSOARP00000019404	ENSOARP00000010393	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Uncharacterized protein.	0.429
CYB5R2	LOC101122662	ENSOARP00000016829	ENSOARP00000014406	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Uncharacterized protein.	0.429
CYB5R2	W5PIX3_SHEEP	ENSOARP00000016829	ENSOARP00000010393	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Uncharacterized protein.	0.429
CYB5R3	LOC101122662	ENSOARP00000020430	ENSOARP00000014406	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Uncharacterized protein.	0.429
CYB5R3	W5PIX3_SHEEP	ENSOARP00000020430	ENSOARP00000010393	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	Uncharacterized protein.	0.429
CYB5RL	LOC101122662	ENSOARP00000007517	ENSOARP00000014406	FAD-binding FR-type domain-containing protein.	Uncharacterized protein.	0.463
CYB5RL	W5PIX3_SHEEP	ENSOARP00000007517	ENSOARP00000010393	FAD-binding FR-type domain-containing protein.	Uncharacterized protein.	0.463
LOC101122662	CYB5R1	ENSOARP00000014406	ENSOARP00000019404	Uncharacterized protein.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.429
LOC101122662	CYB5R2	ENSOARP00000014406	ENSOARP00000016829	Uncharacterized protein.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.429
LOC101122662	CYB5R3	ENSOARP00000014406	ENSOARP00000020430	Uncharacterized protein.	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.429
LOC101122662	CYB5RL	ENSOARP00000014406	ENSOARP00000007517	Uncharacterized protein.	FAD-binding FR-type domain-containing protein.	0.463
LOC101122662	MTRR	ENSOARP00000014406	ENSOARP00000015544	Uncharacterized protein.	5-methyltetrahydrofolate-homocysteine methyltransferase reductase.	0.404
LOC101122662	NOS1	ENSOARP00000014406	ENSOARP00000004517	Uncharacterized protein.	Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family.	0.404
LOC101122662	NOS2	ENSOARP00000014406	ENSOARP00000017986	Uncharacterized protein.	Nitric oxide synthase; Produces nitric oxide (NO).	0.404
LOC101122662	NOS3	ENSOARP00000014406	ENSOARP00000002091	Uncharacterized protein.	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity).	0.404
LOC101122662	OXNAD1	ENSOARP00000014406	ENSOARP00000016517	Uncharacterized protein.	Oxidoreductase NAD binding domain containing 1.	0.429
LOC101122662	W5PIX3_SHEEP	ENSOARP00000014406	ENSOARP00000010393	Uncharacterized protein.	Uncharacterized protein.	0.817
MTRR	LOC101122662	ENSOARP00000015544	ENSOARP00000014406	5-methyltetrahydrofolate-homocysteine methyltransferase reductase.	Uncharacterized protein.	0.404
MTRR	W5PIX3_SHEEP	ENSOARP00000015544	ENSOARP00000010393	5-methyltetrahydrofolate-homocysteine methyltransferase reductase.	Uncharacterized protein.	0.404