11 items (Ovis aries) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DIAPH2	Diaphanous related formin 2. (980 aa)
	SIAH2	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (263 aa)
	W5P5E4_SHEEP	DNA_MISMATCH_REPAIR_2 domain-containing protein. (835 aa)
	FOXL2	Fork-head domain-containing protein. (158 aa)
	BMP15	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity). (402 aa)
	MSH4	MutS homolog 4. (935 aa)
	GDF9	Growth/differentiation factor 9; Required for ovarian folliculogenesis. (453 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	DAZL	Deleted in azoospermia like. (258 aa)
	OVOL1	Ovo like transcriptional repressor 1. (267 aa)
	SPO11	SPO11 initiator of meiotic double stranded breaks. (395 aa)

Your Current Organism:

Ovis aries

NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP15	DAZL	ENSOARP00000010055	ENSOARP00000016597	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	Deleted in azoospermia like.	0.562
BMP15	DIAPH2	ENSOARP00000010055	ENSOARP00000002593	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	Diaphanous related formin 2.	0.414
BMP15	FOXL2	ENSOARP00000010055	ENSOARP00000007704	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	Fork-head domain-containing protein.	0.674
BMP15	GDF9	ENSOARP00000010055	ENSOARP00000014175	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	0.894
DAZL	BMP15	ENSOARP00000016597	ENSOARP00000010055	Deleted in azoospermia like.	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	0.562
DAZL	FOXL2	ENSOARP00000016597	ENSOARP00000007704	Deleted in azoospermia like.	Fork-head domain-containing protein.	0.498
DAZL	GDF9	ENSOARP00000016597	ENSOARP00000014175	Deleted in azoospermia like.	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	0.702
DAZL	SPO11	ENSOARP00000016597	ENSOARP00000019324	Deleted in azoospermia like.	SPO11 initiator of meiotic double stranded breaks.	0.689
DAZL	W5P5E4_SHEEP	ENSOARP00000016597	ENSOARP00000005647	Deleted in azoospermia like.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.510
DIAPH2	BMP15	ENSOARP00000002593	ENSOARP00000010055	Diaphanous related formin 2.	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	0.414
DIAPH2	W5P5E4_SHEEP	ENSOARP00000002593	ENSOARP00000005647	Diaphanous related formin 2.	DNA_MISMATCH_REPAIR_2 domain-containing protein.	0.461
FGF9	FOXL2	ENSOARP00000014422	ENSOARP00000007704	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fork-head domain-containing protein.	0.407
FOXL2	BMP15	ENSOARP00000007704	ENSOARP00000010055	Fork-head domain-containing protein.	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	0.674
FOXL2	DAZL	ENSOARP00000007704	ENSOARP00000016597	Fork-head domain-containing protein.	Deleted in azoospermia like.	0.498
FOXL2	FGF9	ENSOARP00000007704	ENSOARP00000014422	Fork-head domain-containing protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.407
FOXL2	GDF9	ENSOARP00000007704	ENSOARP00000014175	Fork-head domain-containing protein.	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	0.695
FOXL2	MSH4	ENSOARP00000007704	ENSOARP00000013633	Fork-head domain-containing protein.	MutS homolog 4.	0.401
GDF9	BMP15	ENSOARP00000014175	ENSOARP00000010055	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity).	0.894
GDF9	DAZL	ENSOARP00000014175	ENSOARP00000016597	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	Deleted in azoospermia like.	0.702
GDF9	FOXL2	ENSOARP00000014175	ENSOARP00000007704	Growth/differentiation factor 9; Required for ovarian folliculogenesis.	Fork-head domain-containing protein.	0.695