STRINGSTRING
GAPDH GAPDH NOS3 NOS3 NOS1 NOS1 SOD2 SOD2 GPX3 GPX3 GPX7 GPX7 BCL2 BCL2 CASP3 CASP3 CALCA-2 CALCA-2 LOC101107359 LOC101107359 GPX2 GPX2 GPX8 GPX8 CASP9 CASP9 TGFA TGFA APAF1 APAF1 PRKG2 PRKG2 W5QBT3_SHEEP W5QBT3_SHEEP MT4 MT4 GPX6 GPX6 GPX5 GPX5 HBEGF HBEGF GAST GAST LOC101103784 LOC101103784
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1205 aa)
NOS1Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR (By similarity); Belongs to the NOS family. (1463 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (151 aa)
GPX7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (165 aa)
BCL2BCL2 apoptosis regulator. (139 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (275 aa)
CALCA-2Calcitonin gene-related peptide; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role; Belongs to the calcitonin family. (37 aa)
LOC101107359Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (146 aa)
GPX8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (452 aa)
TGFAProtransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa)
APAF1Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1251 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
W5QBT3_SHEEPGlyceraldehyde-3-phosphate dehydrogenase. (327 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
GPX6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
GPX5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (219 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
GASTBig gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. (104 aa)
LOC101103784Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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