STRINGSTRING
JAK1 JAK1 CALR CALR CCL11 CCL11 B4GALT1 B4GALT1 TAPBP TAPBP TYMS TYMS ACADSB ACADSB STAT2 STAT2 PYGM PYGM RXRB RXRB FABP7 FABP7 GAPDH GAPDH NFKBIA NFKBIA PTDSS2 PTDSS2 HSPA6 HSPA6 PYGB PYGB TXN TXN TANK TANK IRF7 IRF7 PDGFRB PDGFRB IL10 IL10 TLR9 TLR9 TADA3 TADA3 MECP2 MECP2 TLR4 TLR4 DBN1 DBN1 MSN MSN SEPTIN7 SEPTIN7 COX8A COX8A CTSD CTSD B2M B2M TBK1 TBK1 IFNG IFNG MPPE1 MPPE1 MYD88 MYD88 PRKCG PRKCG TNFRSF12A TNFRSF12A TLR6 TLR6 TLR1 TLR1 SOCS3 SOCS3 PBX2 PBX2 RGS8 RGS8 IRF9 IRF9 PRSS35 PRSS35 NDUFB5 NDUFB5 PYGL PYGL CALR3 CALR3 ZNF398 ZNF398 W5QBT3_SHEEP W5QBT3_SHEEP BPI BPI GPD1 GPD1 TOLLIP TOLLIP EARS2 EARS2 NCKAP1 NCKAP1 PPARG PPARG NCKAP1L NCKAP1L TYK2 TYK2 STAT1 STAT1 JAK2 JAK2 IRF3 IRF3 IFNAR1 IFNAR1 IFNGR2 IFNGR2 IL6 IL6 GATA1 GATA1 SIT1 SIT1 KIFAP3 KIFAP3 CDK9 CDK9
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAK1Tyrosine-protein kinase. (1161 aa)
CALRCalreticulin. (417 aa)
CCL11C-C motif chemokine. (101 aa)
B4GALT1Uncharacterized protein. (402 aa)
TAPBPIg-like domain-containing protein. (434 aa)
TYMSThymidylate synthetase. (352 aa)
ACADSBAcyl-CoA dehydrogenase short/branched chain. (434 aa)
STAT2Signal transducer and activator of transcription. (849 aa)
PYGMGlycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
RXRBRetinoid X receptor beta. (539 aa)
FABP7Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] (334 aa)
NFKBIAANK_REP_REGION domain-containing protein. (311 aa)
PTDSS2Uncharacterized protein. (144 aa)
HSPA6Heat shock protein family A (Hsp70) member 6; Belongs to the heat shock protein 70 family. (579 aa)
PYGBGlycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (844 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
TANKTRAF family member associated NFKB activator. (458 aa)
IRF7Interferon regulatory factor 7. (485 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (177 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (958 aa)
TADA3Transcriptional adaptor 3. (369 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (482 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (841 aa)
DBN1Drebrin 1. (633 aa)
MSNMoesin. (665 aa)
SEPTIN7Septin 7; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (418 aa)
COX8ACytochrome c oxidase subunit 8A. (69 aa)
CTSDCathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. (121 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (118 aa)
TBK1TANK binding kinase 1. (730 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
MPPE1Metallophosphoesterase 1. (397 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (187 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (640 aa)
TNFRSF12ATNF receptor superfamily member 12A. (129 aa)
TLR6Toll-like receptor. (797 aa)
TLR1Toll-like receptor. (796 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
PBX2PBX homeobox 2. (427 aa)
RGS8Regulator of G protein signaling 8. (180 aa)
IRF9Interferon regulatory factor 9. (462 aa)
PRSS35Serine protease 35. (412 aa)
NDUFB5NADH:ubiquinone oxidoreductase subunit B5. (189 aa)
PYGLGlycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity). (779 aa)
CALR3Calreticulin. (384 aa)
ZNF398Zinc finger protein 398. (509 aa)
W5QBT3_SHEEPGlyceraldehyde-3-phosphate dehydrogenase. (327 aa)
BPIBactericidal permeability increasing protein. (536 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
TOLLIPC2 domain-containing protein. (65 aa)
EARS2Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (535 aa)
NCKAP1NCK associated protein 1. (1126 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
TYK2Tyrosine-protein kinase. (1161 aa)
STAT1Signal transducer and activator of transcription. (804 aa)
JAK2Tyrosine-protein kinase. (1133 aa)
IRF3Interferon regulatory factor 3. (411 aa)
IFNAR1Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). (561 aa)
IFNGR2Interferon gamma receptor 2. (347 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (210 aa)
GATA1Uncharacterized protein. (406 aa)
SIT1Signaling threshold regulating transmembrane adaptor 1. (219 aa)
KIFAP3Kinesin associated protein 3. (792 aa)
CDK9Cyclin dependent kinase 9. (341 aa)
Your Current Organism:
Ovis aries
NCBI taxonomy Id: 9940
Other names: O. aries, Ovis ammon aries, Ovis orientalis aries, Ovis ovis, domestic sheep, lambs, sheep, wild sheep
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